Articles tagged "Multicenter studies"

2020 American Transplant Congress
RNA Sequencing of Urine RNA Samples for Biomarker Discovery
K. S. Keslar¹, D. Margeta¹, M. Abecassis², J. J. Friedewald², P. S. Heeger³, R. L. Fairchild¹
¹Cleveland Clinic, Cleveland, OH, ²Northwestern University, Chicago, IL, ³Icahn School of Medicine, New York, NY
*Purpose: An accurate, noninvasive assay based on urinary gene expression profiles would be a powerful tool for clinical management of kidney transplant patients. We have…
2020 American Transplant Congress
TRANSFORM Study (NCT01950819): Application of the Ibox Clinical Trial Simulation Tool to Project Long-Term Kidney Allograft Outcome
G. Divard¹, O. Aubert¹, M. Raynaud¹, J. Pascual², F. Vincenti³, P. Bernhardt⁴, C. Legendre¹, A. Loupy¹, .. on behalf of TRANSFORM Investigators⁵
¹INSERM U970, Paris Transplant Group, Paris, France, ²Department of Nephrology, Hospital del Mar/Universitat Autònoma de Barcelona, Barcelona, Spain, ³Department of Surgery/Kidney Transplant Service, University of California, San Francisco, CA, ⁴Research and Development, Novartis Pharma AG, Basel, Switzerland, ⁵TRANSFORM Investigators, Basel, Switzerland
*Purpose: The development of pharmaceutical agents in transplantation is currently limited by long waits for hard endpoints. We sought to use a risk stratification system…
2020 American Transplant Congress
Noninvasive Detection of Subclinical Rejection in Urine RNA
K. S. Keslar¹, D. Margeta¹, J. J. Friedewald², M. Abecassis², R. B. Mannon³, P. S. Heeger⁴, R. L. Fairchild¹
¹Cleveland Clinic, Cleveland, OH, ²Northwestern University, Chicago, IL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Icahn School of Medicine, New York, NY
*Purpose: Subclinical rejection may lead to long-term graft injury and can currently only be detected by repeated biopsies. A noninvasive method is needed to monitor…
2020 American Transplant Congress
Three-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection – Early Impact of Interleukin-6 Blockade on Donor-Specific Antibody Levels, Rejection Morphology and Gene Expression
G. A. Böhmig¹, M. Dürr², B. Jilma³, F. Eskandary¹, E. Chong⁴, S. Schranz³, K. Doberer¹, M. Wahrmann¹, A. Borski¹, H. Regele⁵, J. Kläger⁵, R. Reindl-Schwaighofer¹, J. Reeve⁶, K. Budde², P. F. Halloran⁶
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Nephrology Department, Charité Berlin, Berlin, Germany, ³Dept. of Clin. Pharmacology, Medical University of Vienna, Vienna, Austria, ⁴Vitaeris Inc., Vancouver, BC, Canada, ⁵Dept. of Clin. Pathology, Medical University of Vienna, Vienna, Austria, ⁶Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada
*Purpose: Targeting Interleukin-6 (IL-6) is a promising strategy to counteract antibody-mediated rejection (ABMR). This phase 2 trial (NCT03444103) was designed to evaluate the safety and…
2020 American Transplant Congress
Care Processes and Structures Associated with Higher Medication Adherence: The Positive Adherence Study
A. Dabirzadeh¹, B. Foster¹, M. Dahhou¹, S. Mital²
¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Hospital for Sick Children, Toronto, ON, Canada
*Purpose: We aimed to identify care processes and structures that are independently associated with higher medication adherence among adolescent and young adult transplant recipients.*Methods: We…
2020 American Transplant Congress
Burnout and Professional Fulfillment among Pediatric Sold Organ Transplant Clinicians Pediatric Transplant
C. Bogle¹, M. K. Cousino Hood², E. M. Fredericks³, J. Magee⁴, S. Warren¹, E. Blume¹
¹Advanced Cardiac Therapies, Boston Children's Hospital, Boston, MA, ²Pediatric Cardiology, C.S. Mott Children's Hospital, Ann Arbor, MI, ³Pediatric Psychology, C.S. Mott Children's Hospital, Ann Arbor, MI, ⁴Transplant, C.S. Mott Children's Hospital, Ann Arbor, MI
*Purpose: Burnout has been associated with worse patient outcomes with increased medical errors and nosocomial infections as well as adverse effect on healthcare providers, such…
2019 American Transplant Congress
Facilitators and Barriers to Implementing the Live Donor Champion Program
A. D. Love¹, D. R. Helfer¹, S. Rasmussen¹, M. Johnson¹, J. M. Konel¹, J. R. Wellen², S. M. Nazarian³, E. King¹, D. L. Segev¹, T. Hwee¹, A. M. Cameron¹, M. L. Henderson¹, E. J. Gordon⁴, J. M. Garonzik Wang¹
¹Surgery, Johns Hopkins University, Baltimore, MD, ²Abdominal Transplant Surgery, Washington University School of Medicine, St. Louis, MO, ³Surgery, Penn Transplant Institute, Philadelphia, PA, ⁴Surgery, Northwestern Feinberg School of Medicine, Chicago, IL
*Purpose: The Live Donor Champion (LDC) Program is an intervention designed to increase kidney transplant candidate knowledge about living donor kidney transplantation (LDKT) and ability…
2019 American Transplant Congress
Atypical Hemolytic Uremic Syndrome Concomitant Complement Factor H Gene Variations Leading to Early Renal Allograft Loss: Multicenter Cases Report from China
J. Wen¹, Z. Jin², N. Gong³, X. Xu⁴
¹Jinling Hospital, Nanjing, Jiangsu, China, ²Department of Renal Transplantation, The First Affiliated Hospital of Medical College,Xi’an Jiaotong University, Xi 'an, China, ³Organ Transplantation, Organ Transplantation Key Laboratory of the Ministry of Education, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ⁴The First Hospital Affiliated to Army Medical University, Beijing, China
*Purpose: The ratio of early renal allograft loss caused by hyperacute rejection, severe surgical complications and sever infection decreased gradually during recent years. Atypical hemolytic…
2019 American Transplant Congress
Delayed Kidney Transplantation in Combined Liver Kidney Transplantation: A Validation Analysis by the UNOS Registry
L. Chau, M. Safwan, M. Rizzari, K. Collins, A. Yoshida, M. Abouljoud, D. Moonka, S. Nagai
Transplant Surgery, Henry Ford Hospital, Detroit, MI
*Purpose: Delayed kidney transplantation for patients undergoing combined liver-kidney transplant (CLKT) have been suggested to improve patient survival and kidney function compared to simultaneous liver-kidney…
2019 American Transplant Congress
Timeline for Resuming Physical Activities after Renal Transplantation: A Mid West Pediatric Nephrology Consortium Study
P. Baddi¹, H. Patel², H. Janjua³, D. Y. Kim⁴, A. Jain⁵
¹Beaumont Children's Hospital, Royal Oak, MI, ²Nationwide Children's Hospital, Columbus, OH, ³Cleveland Clinic Children's Hospital, Cleveland, OH, ⁴Children's Hospital of Michigan and Henry Ford Hospital, Detroit, MI, ⁵Children's Hospital of Michigan, Detroit, MI
*Purpose: To assess the practice patterns of the timeline for safely resuming various physical activities after pediatric kidney transplant.*Methods: An anonymous web-based survey was distributed…

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