Articles tagged "Multicenter studies"

2020 American Transplant Congress
Transarterial Chemoembolization and Radio-Embolization are Similarly Efficacious in Achieving Successful Hepatocellular Carcinoma (HCC) Down-Staging: Results from the Multicenter Evaluation of Reduction in Tumor Size Before Liver Transplantation (MERITS-LT) Consortium
N. Mehta¹, J. Guy², C. Frenette³, P. Tabrizian⁴, M. Hoteit⁵, N. Parikh⁶, T. Ghaziani⁷, R. Dhanasekaran⁷, J. L. Dodge¹, M. L. Holzner⁴, S. Florman⁴, F. Yao¹
¹UCSF, SF, CA, ²CPMC, SF, CA, ³Scripps Hospital, La Jolla, CA, ⁴Mt Sinai, NY, NY, ⁵U. Pennsylvania, Philadelphia, PA, ⁶U. Michigan, Ann Arbor, MI, ⁷Stanford, Palo Alto, CA
*Purpose: United Network of Organ Sharing (UNOS) Region 5 has reported excellent liver transplantation (LT) outcomes after successful down-staging (DS) in HCC patients exceeding Milan…
2020 American Transplant Congress
Reactivation of BK Polyomavirus after Kidney Transplantation: A Multi-Center Collaboration Examining the Impact of Adherence to a Screening Protocol on Clinical Outcomes
R. Rogers¹, F. Cheema², M. Chobanian³, Z. Ebcioglu², H. Gilligan⁴, R. Gohh¹, N. Goyal⁵, M. Pavlakis⁶, N. Rodig⁷, A. Rossi⁸, J. Singh², C. S. Tan⁶
¹Warren Alpert Medical School of Brown University, Providence, RI, ²Hartford Hospital, Hartford, CT, ³Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Massachusetts General Hospital, Boston, MA, ⁵Tufts University School of Medicine, Boston, MA, ⁶Beth Israel Deaconess Medical Center, Boston, MA, ⁷Boston Children's Hospital, Boston, MA, ⁸Maine Medical Center, Portland, ME
*Purpose: Reactivation of BK polyomavirus (BK) after kidney transplantation (KT) is common and can lead to adverse clinical outcomes such as allograft nephropathy (BKAN). In…
2020 American Transplant Congress
TRANSBIO Study: Clinical Evaluation of Immunobiogram, a Novel In Vitro Diagnostic Immunoassay to Guide Adjustment of Immunosuppressive Therapy in Kidney Transplantation
J. Pascual¹, C. Jiménez², M. Krajewska³, C. Kotton⁴, D. Seron⁵, J. Portolés⁶, O. Witzke⁷, S. S. Sorensen⁸, A. Andrés⁹, T. Díez¹⁰, A. Ortega¹⁰, I. Portero¹⁰
¹Consorci Mar Parc de Salut, Barcelona, Spain, ²La Paz Hospital, Madrid, Spain, ³Wroclaw Medical University, Wroclaw, Poland, ⁴Massachusetts General Hospital, Boston, MA, ⁵Vall d’Hebron Hospital, Barcelona, Spain, ⁶Puerta de Hierro Mahadahonda Hospital, Madrid, Spain, ⁷University Hospital Essen, University Duisburg-Essen, Essen, Germany, ⁸Rigshospitalet, Copenhagen, Denmark, ⁹12 de Octubre Hospital, Madrid, Spain, ¹⁰Biohope Scientific Solutions for Human Health SL, Madrid, Spain
*Purpose: Immunobiogram (IMBG) is a first-in-class blood-based pharmacodynamic immunoassay that provides the sensitivity/resistance profile of each patient’s lymphocytes to a panel of immunosuppressive drugs (IS).…
2020 American Transplant Congress
The State of Interventional Clinical Trials in Solid Organ Transplant: Insights from a Systematic Analysis of Clinicaltrials.gov
A. C. Swaminathan¹, J. Li¹, K. Chiswell¹, W. McManigle¹, I. O’Doherty², W. Fitzsimmons³, J. L. Todd¹, S. Tibbs⁴, S. M. Palmer¹
¹Duke Clinical Research Institute, Durham, NC, ²Critical Path Institute, Tuscan, AZ, ³Fitzsimmons LLC, Chicago, IL, ⁴Duke University, Durham, NC
*Purpose: The approach to immunosuppression after solid organ transplant has remained relatively unchanged for almost 20 years, despite the high prevalence of immunosuppression-related complications and…
2020 American Transplant Congress
A Monocyte-Derived MicroRNA Signature for Antibody-Mediated Rejection in Kidney Transplantation
C. Tinel¹, B. Lamarthée¹, F. Von Tokarski¹, M. Rabant², C. Legendre¹, W. Gwinner³, M. Naesens⁴, P. Marquet⁵, D. Anglicheau¹
¹Kidney Transplantation, Inserm U1151, Necker Hospital, Paris, France, ²Pathology, Necker Hospital, Paris, France, ³Nephrology, Hannover Medical School, Hannover, Germany, ⁴Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium, ⁵Nephrology, Dialysis and Transplantation, Inserm U850, Limoges University Hospital, Limoges, France
*Purpose: MicroRNAs (miRNAs) are small noncoding RNAs which regulate mRNA expression at the posttranscriptional level. We investigated blood miRNAs as non-invasive biomarkers in kidney transplantation…
2020 American Transplant Congress
RNA Sequencing of Urine RNA Samples for Biomarker Discovery
K. S. Keslar¹, D. Margeta¹, M. Abecassis², J. J. Friedewald², P. S. Heeger³, R. L. Fairchild¹
¹Cleveland Clinic, Cleveland, OH, ²Northwestern University, Chicago, IL, ³Icahn School of Medicine, New York, NY
*Purpose: An accurate, noninvasive assay based on urinary gene expression profiles would be a powerful tool for clinical management of kidney transplant patients. We have…
2019 American Transplant Congress
To Each Their Own: Center-Level Variation in Tailoring Induction Immunosuppression to Kidney Transplant Recipients
S. Bae, A. Massie, J. Garonzik Wang, M. McAdams DeMarco, J. Coresh, D. Segev
Johns Hopkins University, Baltimore, MD
*Purpose: Ideally, induction immunosuppression should be selected in a personalized manner. However, there is little knowledge of what clinical factors are considered in this process…
2019 American Transplant Congress
Patterns and Predictors of Alcohol Use after Early Liver Transplant for Alcoholic Hepatitis
B. P. Lee¹, M. Rinella², G. Im³, J. Rice⁴, O. Fix⁵, G. Therapondos⁶, H. Han⁷, D. Victor⁸, E. Weinberg⁹, C. Hsu¹⁰, M. Voigt¹¹, H. Maddur², S. Eswaran¹², D. Foley⁴, R. Ghobrial⁸, L. Dinges⁵, J. Dodge¹, N. Mehta¹, M. Lucey⁴, N. Terrault¹
¹UCSF, SF, CA, ²NW, Chicago, IL, ³MtSinai, NYC, NY, ⁴Wisconsin, Madison, WI, ⁵Swedish, Seattle, WA, ⁶Ochsner, Jefferson, LA, ⁷USC, LA, CA, ⁸Houston, Houston, TX, ⁹Penn, Philadelphia, PA, ¹⁰Georgetown, DC, WA, ¹¹Iowa, Iowa City, IA, ¹²Rush, Chicago, IL
*Purpose: ACCELERATE-AH is a multicenter consortium studying early liver transplant (LT) for alcoholic hepatitis (AH). To inform surveillance and intervention strategies for post-LT alcohol use,…
2019 American Transplant Congress
Dialysis Facility Provider Transplant Knowledge after a Randomized Multilevel Intervention to Increase Kidney Transplant Referral and Evaluation in the Southeast
K. Maroney¹, R. Hamoda¹, L. McPherson¹, A. Cruz², S. Pastan¹, L. Plantinga¹, S. Paul¹, M. Ellis³, D. DuBay⁴, A. Reeves-Daniel⁵, R. Detwiler⁶, E. Hartmann⁷, H. Jones⁸, B. Thrasher⁹, C. Zayas¹⁰, L. Mulloy¹⁰, S. Wright¹¹, R. Patzer¹
¹Emory University, Atlanta, GA, ²IPRO Network of the South Atlantic, Raleigh, NC, ³Duke University, Durham, NC, ⁴Medical University of South Carolina, Charleston, SC, ⁵Wake Forest Health Transplant Center, Winston-Salem, NC, ⁶UNC Center for Transplantation, Chapel Hill, NC, ⁷Piedmont Transplant Institute, Atlanta, GA, ⁸Vidant Medical Center Transplant Services, Greenville, NC, ⁹Carolinas Transplant Center, Charlotte, NC, ¹⁰Augusta University, Augusta, GA, ¹¹IPRO Network of the South Atlantic, Morrisville, NC
*Purpose: Dialysis facility provider kidney transplantation (KTx) knowledge influences patient transplant access. The Reducing Disparities in Access to kidNey Transplantation (RaDIANT) Regional Study is a…
2019 American Transplant Congress
Gender Disparity: Do Female Donors Suffer from Living Kidney Donation?
N. Ebeling¹, B. Suwelack¹, M. Burgmer², a. the SoLKiD Study Group¹
¹MED D, Universitaetsklinikum Muenster, Muenster, Germany, ²Psychosomatic medicine, Universitaetsklinikum Muenster, Muenster, Germany
*Purpose: Transplantation and optional living donation is the therapy of choice in end-stage renal disease. Due to the increase of living kidney donoration (LD), the…

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