2020 American Transplant Congress
Frailty Prior to Hospital Discharge Predicts Mortality after Cirrhosis-Related Admissions
1University of Pennsylvania, Philadelphia, PA, 2University of Pittsburgh, Pittsburgh, PA
*Purpose: Inpatient frailty assessment and its utility in clinical care is understudied in liver transplant (LT) candidates. Study objectives were to quantify physical frailty among…2020 American Transplant Congress
A Multicenter Analysis of the Proportion and Pattern of Unexplained HLA Antibodies in Kidney Recipients without a History of Sensitization
*Purpose: Previous studies report a high prevalence of unexplained antibody reactivities on the single antigen bead (SAB) test. In a contemporary multicenter cohort of non-sensitized…2020 American Transplant Congress
Integrated Multicohort Analysis of Transcriptome Profiles Identifies Blood Gene Signature to Distinguish Rejection from Infection in Patients with Solid Organ Transplants
School of Medicine, Stanford University, Stanford, CA
*Purpose: Allograft rejection and infection are now leading causes of morbidity and mortality in transplant recipients. Current diagnosis relies on nonspecific markers of graft injury,…2020 American Transplant Congress
Atrial Fibrillation Predicts Inferior Survival in Liver Transplant Recipients of Advanced Age in a Large Multicenter U.S. Cohort
*Purpose: More liver transplants (LT) are being performed in patients >65 years (y) - a population with higher rates of cardiovascular (CV) disease. It is…2020 American Transplant Congress
Evolution of Molecular Lung Transplant Biopsy Assessment: Rejection Can be Detected in Mucosal as Well as Transbronchial Biopsies
*Purpose: We recently developed a Molecular Microscope® (MMDx) rejection assessment platform for mucosal biopsies from the third airway bifurcation (3BMB) and transbronchial biopsies (TBB) from…2020 American Transplant Congress
Reactivation of BK Polyomavirus after Kidney Transplantation: A Multi-Center Collaboration Examining the Impact of Adherence to a Screening Protocol on Clinical Outcomes
*Purpose: Reactivation of BK polyomavirus (BK) after kidney transplantation (KT) is common and can lead to adverse clinical outcomes such as allograft nephropathy (BKAN). In…2020 American Transplant Congress
Transarterial Chemoembolization and Radio-Embolization are Similarly Efficacious in Achieving Successful Hepatocellular Carcinoma (HCC) Down-Staging: Results from the Multicenter Evaluation of Reduction in Tumor Size Before Liver Transplantation (MERITS-LT) Consortium
*Purpose: United Network of Organ Sharing (UNOS) Region 5 has reported excellent liver transplantation (LT) outcomes after successful down-staging (DS) in HCC patients exceeding Milan…2020 American Transplant Congress
The State of Interventional Clinical Trials in Solid Organ Transplant: Insights from a Systematic Analysis of Clinicaltrials.gov
*Purpose: The approach to immunosuppression after solid organ transplant has remained relatively unchanged for almost 20 years, despite the high prevalence of immunosuppression-related complications and…2020 American Transplant Congress
TRANSBIO Study: Clinical Evaluation of Immunobiogram, a Novel In Vitro Diagnostic Immunoassay to Guide Adjustment of Immunosuppressive Therapy in Kidney Transplantation
*Purpose: Immunobiogram (IMBG) is a first-in-class blood-based pharmacodynamic immunoassay that provides the sensitivity/resistance profile of each patient’s lymphocytes to a panel of immunosuppressive drugs (IS).…2020 American Transplant Congress
RNA Sequencing of Urine RNA Samples for Biomarker Discovery
*Purpose: An accurate, noninvasive assay based on urinary gene expression profiles would be a powerful tool for clinical management of kidney transplant patients. We have…
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