Articles tagged "Multicenter studies"

2021 American Transplant Congress
The Impact of the Covid-19 Pandemic on Measures of Transplant Activity is Higher in Lower-Income Countries: A Multinational Survey Study
S. Sandal¹, B. Boyarsky², P. Chiang², A. Massie², D. Segev², M. Cantarovich¹
¹McGill University, Montreal, QC, Canada, ²Johns Hopkins University, Baltimore, MD
*Purpose: The COVID-19 pandemic has affected the field of solid organ transplantation due to the “ramp-down” of activity during the initial months. Impact on transplant…
2021 American Transplant Congress
Posttraumatic Stress and Medication Adherence in Pediatric Transplant Recipients
S. Duncan-Park¹, L. Danziger-Isakov², B. Armstrong³, N. Williams⁴, J. Odim⁴, E. Shemesh⁵, S. Sweet⁶, R. Annunziato¹
¹Icahn School of Medicine at Mount Sinai and Fordham University, New York, NY, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rho Inc., Durham, NC, ⁴NIAID, Bethesda, MD, ⁵Icahn School of Medicine at Mount Sinai, New York, NY, ⁶Washington University in St. Louis, St. Louis, MO
*Purpose: We investigated the relationship between posttraumatic stress symptoms (PTSS), medication adherence, and quality of life (QoL) in adolescent transplant recipients.*Methods: This protocol of the…
2021 American Transplant Congress
Simultaneous Heart-Liver-Kidney Transplantation Survival: National and Single-Center Outcomes
U. A. Siddiqi¹, P. S. Combs¹, G. Kim², T. Baker³, Y. Becker¹, V. Jeevanandam¹
¹Section of Cardiac Surgery, University of Chicago Medicine, Chicago, IL, ²Section of Cardiology, University of Chicago Medicine, Chicago, IL, ³University of Chicago Medicine, Chicago, IL
*Purpose: Simultaneous Heart-Liver-Kidney transplantation (SHLKTx) is an incredibly rare, high-risk operation undergone by well-selected patients presenting with multi-organ failure. Our center has performed 10 of…
2021 American Transplant Congress
Covid-19 Caseload and Management Practices Vary by Program-Level Factors: A Multinational Survey Study
S. Sandal¹, B. Boyarsky², P. Chiang², A. Massie², D. Segev², M. Cantarovich¹
¹McGill University, Montreal, QC, Canada, ²Johns Hopkins University, Baltimore, MD
*Purpose: During the pandemic, the COVID-19 patient caseload (CPC) is thought to be highly variable and likely dependant on the cumulative COVID-19 incidence (CCI) of…
2021 American Transplant Congress
SARS-CoV-2 Infection Among Kidney Transplant Recipients: A Multicenter Brazilian Cohort Study
T. Sandes-Freitas¹, J. Medina-Pestana², o. COVID-19 Brazil Study Group³
¹Universidade Federal do Ceará, Fortaleza, Brazil, ²Hospital do Rim, São Paulo, Brazil, ³Brazil, Brazil, Brazil
*Purpose: Limited data are available on COVID-19 clinical presentation and outcomes among kidney transplant (KT) recipients.*Methods: Multicenter Brazilian cohort of KT patients with laboratory-confirmed SARS-CoV-2…
2020 American Transplant Congress
TRANSFORM Study (NCT01950819): Application of the Ibox Clinical Trial Simulation Tool to Project Long-Term Kidney Allograft Outcome
G. Divard¹, O. Aubert¹, M. Raynaud¹, J. Pascual², F. Vincenti³, P. Bernhardt⁴, C. Legendre¹, A. Loupy¹, .. on behalf of TRANSFORM Investigators⁵
¹INSERM U970, Paris Transplant Group, Paris, France, ²Department of Nephrology, Hospital del Mar/Universitat Autònoma de Barcelona, Barcelona, Spain, ³Department of Surgery/Kidney Transplant Service, University of California, San Francisco, CA, ⁴Research and Development, Novartis Pharma AG, Basel, Switzerland, ⁵TRANSFORM Investigators, Basel, Switzerland
*Purpose: The development of pharmaceutical agents in transplantation is currently limited by long waits for hard endpoints. We sought to use a risk stratification system…
2020 American Transplant Congress
Noninvasive Detection of Subclinical Rejection in Urine RNA
K. S. Keslar¹, D. Margeta¹, J. J. Friedewald², M. Abecassis², R. B. Mannon³, P. S. Heeger⁴, R. L. Fairchild¹
¹Cleveland Clinic, Cleveland, OH, ²Northwestern University, Chicago, IL, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Icahn School of Medicine, New York, NY
*Purpose: Subclinical rejection may lead to long-term graft injury and can currently only be detected by repeated biopsies. A noninvasive method is needed to monitor…
2020 American Transplant Congress
Three-Month Results of a Phase 2 Trial Evaluating Clazakizumab in Late Antibody-Mediated Rejection – Early Impact of Interleukin-6 Blockade on Donor-Specific Antibody Levels, Rejection Morphology and Gene Expression
G. A. Böhmig¹, M. Dürr², B. Jilma³, F. Eskandary¹, E. Chong⁴, S. Schranz³, K. Doberer¹, M. Wahrmann¹, A. Borski¹, H. Regele⁵, J. Kläger⁵, R. Reindl-Schwaighofer¹, J. Reeve⁶, K. Budde², P. F. Halloran⁶
¹Department of Medicine III, Medical University of Vienna, Vienna, Austria, ²Nephrology Department, Charité Berlin, Berlin, Germany, ³Dept. of Clin. Pharmacology, Medical University of Vienna, Vienna, Austria, ⁴Vitaeris Inc., Vancouver, BC, Canada, ⁵Dept. of Clin. Pathology, Medical University of Vienna, Vienna, Austria, ⁶Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada
*Purpose: Targeting Interleukin-6 (IL-6) is a promising strategy to counteract antibody-mediated rejection (ABMR). This phase 2 trial (NCT03444103) was designed to evaluate the safety and…
2020 American Transplant Congress
Care Processes and Structures Associated with Higher Medication Adherence: The Positive Adherence Study
A. Dabirzadeh¹, B. Foster¹, M. Dahhou¹, S. Mital²
¹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Hospital for Sick Children, Toronto, ON, Canada
*Purpose: We aimed to identify care processes and structures that are independently associated with higher medication adherence among adolescent and young adult transplant recipients.*Methods: We…
2020 American Transplant Congress
Burnout and Professional Fulfillment among Pediatric Sold Organ Transplant Clinicians Pediatric Transplant
C. Bogle¹, M. K. Cousino Hood², E. M. Fredericks³, J. Magee⁴, S. Warren¹, E. Blume¹
¹Advanced Cardiac Therapies, Boston Children's Hospital, Boston, MA, ²Pediatric Cardiology, C.S. Mott Children's Hospital, Ann Arbor, MI, ³Pediatric Psychology, C.S. Mott Children's Hospital, Ann Arbor, MI, ⁴Transplant, C.S. Mott Children's Hospital, Ann Arbor, MI
*Purpose: Burnout has been associated with worse patient outcomes with increased medical errors and nosocomial infections as well as adverse effect on healthcare providers, such…