Articles tagged "Multicenter studies"

2021 American Transplant Congress
Trends in Mortality Among Solid Organ Transplant Recipients Hospitalized for Covid-19 During the Course of the Pandemic
M. R. Heldman, O. S. Kates, R. M. Rakita, E. D. Lease, C. E. Fisher, A. P. Limaye
University of Washington, Seattle, WA
*Purpose: Actual and comorbidity-adjusted mortality in hospitalized patients with COVID-19 has declined in the general population during the course of the pandemic. Whether a similar…
2021 American Transplant Congress
Gain of Function Mutations in Latent Membrane Protein 1 of Epstein Barr Virus are Associated with Increased Risk of Post-Transplant Lymphoproliferative Disorder
O. M. Martinez¹, S. M. Krams¹, M. Robien², M. Lapasaran¹, M. Arvedson¹, K. Weinberg¹, S. Boyd¹, B. Armstrong³, C. Twist⁴, D. Gratzinger¹, B. Tan¹, A. Trickey¹, M. Sever³, M. Brown², D. Bernstein¹, C. O. Esquivel¹
¹Stanford University Sch of Med, Stanford, CA, ²NIAID, Rockville, MD, ³Rho, Durham, NC, ⁴Roswell Park, Buffalo, NY
*Purpose: Post-transplant lymphoproliferative disorder (PTLD) remains a serious problem in the pediatric transplant population. Clinical Trials of Organ Transplantation in Children (CTOTC)-06 is a prospective…
2021 American Transplant Congress
Kidney Transplantation Alone in Patients with Compensated Cirrhosis: A Multicenter Study
A. Kassem¹, S. Asrani¹, S. W. Biggins², Y. Darwish¹, M. Nadim³, B. Fischbach¹, T. Fong³
¹Baylor University Medical Center at Dallas, Dallas, TX, ²University of Washington, Seattle, WA, ³USC - Keck, Los Angeles, CA
*Purpose: Patients undergoing kidney transplant (KTA) often have risk factors for liver disease including viral hepatitis and non-alcoholic fatty liver disease (NAFLD). Recent European Association…
2021 American Transplant Congress
The Impact of the Covid-19 Pandemic on Measures of Transplant Activity is Higher in Lower-Income Countries: A Multinational Survey Study
S. Sandal¹, B. Boyarsky², P. Chiang², A. Massie², D. Segev², M. Cantarovich¹
¹McGill University, Montreal, QC, Canada, ²Johns Hopkins University, Baltimore, MD
*Purpose: The COVID-19 pandemic has affected the field of solid organ transplantation due to the “ramp-down” of activity during the initial months. Impact on transplant…
2021 American Transplant Congress
Posttraumatic Stress and Medication Adherence in Pediatric Transplant Recipients
S. Duncan-Park¹, L. Danziger-Isakov², B. Armstrong³, N. Williams⁴, J. Odim⁴, E. Shemesh⁵, S. Sweet⁶, R. Annunziato¹
¹Icahn School of Medicine at Mount Sinai and Fordham University, New York, NY, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Rho Inc., Durham, NC, ⁴NIAID, Bethesda, MD, ⁵Icahn School of Medicine at Mount Sinai, New York, NY, ⁶Washington University in St. Louis, St. Louis, MO
*Purpose: We investigated the relationship between posttraumatic stress symptoms (PTSS), medication adherence, and quality of life (QoL) in adolescent transplant recipients.*Methods: This protocol of the…
2020 American Transplant Congress
MELD is MELD is MELD? Geographic/ Center-Level Variation in Mortality for Patients with the Same MELD Score
T. Ishaque¹, A. B. Massie¹, A. B. Kernodle¹, S. Getsin¹, P. Chaing¹, J. G. Jacqueline Garonzik Wang¹, S. Gentry², D. Segev¹
¹Johns Hopkins University, Baltimore, MD, ²Department of Mathematics, United States Naval Academy, Annapolis, MD
*Purpose: Waitlist candidates living in areas with poor access to health care may have higher mortality risk compared to candidates with same MELD in other…
2020 American Transplant Congress
Frailty Prior to Hospital Discharge Predicts Mortality after Cirrhosis-Related Admissions
M. Serper¹, S. Tao², P. Garren¹, D. Peyton¹, M. A. Dunn², K. Reddy¹, A. Gougol², A. Duarte-Rojo²
¹University of Pennsylvania, Philadelphia, PA, ²University of Pittsburgh, Pittsburgh, PA
*Purpose: Inpatient frailty assessment and its utility in clinical care is understudied in liver transplant (LT) candidates. Study objectives were to quantify physical frailty among…
2020 American Transplant Congress
A Multicenter Analysis of the Proportion and Pattern of Unexplained HLA Antibodies in Kidney Recipients without a History of Sensitization
J. Lan¹, J. S. Gill¹, H. M. Gebel², R. A. Bray², R. Liwski³, A. Vinson⁴, A. Greenshields³, S. Dobrer⁵, O. Gunther⁵, K. Sherwood⁵, F. H. Claas⁶, S. Heidt⁶, G. Karahan⁶, J. Gill⁷, M. Gill¹, U. Varyani¹, P. Jindal¹, P. Keown⁵
¹Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada, ²Pathology, Emory University, Atlanta, GA, ³Pathology, Dalhousie University, Halifax, NS, Canada, ⁴Nephrology, Dalhousie University, Halifax, NS, Canada, ⁵Pathology, University of British Columbia, Vancouver, BC, Canada, ⁶Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands, ⁷Nephrology, Emory University, Atlanta, GA
*Purpose: Previous studies report a high prevalence of unexplained antibody reactivities on the single antigen bead (SAB) test. In a contemporary multicenter cohort of non-sensitized…
2020 American Transplant Congress
Integrated Multicohort Analysis of Transcriptome Profiles Identifies Blood Gene Signature to Distinguish Rejection from Infection in Patients with Solid Organ Transplants
L. C. Murphy, A. Rao, M. Donato, P. Khatri
School of Medicine, Stanford University, Stanford, CA
*Purpose: Allograft rejection and infection are now leading causes of morbidity and mortality in transplant recipients. Current diagnosis relies on nonspecific markers of graft injury,…
2020 American Transplant Congress
Evolution of Molecular Lung Transplant Biopsy Assessment: Rejection Can be Detected in Mucosal as Well as Transbronchial Biopsies
M. D. Parkes¹, K. Halloran², P. Halloran², &. the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: We recently developed a Molecular Microscope® (MMDx) rejection assessment platform for mucosal biopsies from the third airway bifurcation (3BMB) and transbronchial biopsies (TBB) from…