Articles tagged "Multicenter studies"

2017 American Transplant Congress
Detection of Shared and Distinct Gene Expression Signatures in Tissue and Urine During Acute Rejection of Kidney Grafts.
K. Keslar,¹ A. Zmijewska,² J. Chen,² K. Newell,³ P. Heeger,⁴ R. Mannon,² R. Fairchild.¹
¹Department of Immunology, Cleveland Clinic, Cleveland, OH; ²Department of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL; ³Department of Surgery, Emory University, Atlanta, GA; ⁴Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, NY
A major goal of the Clinical Trials in Organ Transplantation (CTOT) studies is the identification of biomarkers that predict or diagnose acute graft rejection in…
2017 American Transplant Congress
Immunosuppression and Graft Rejection in Living-Related HLA-Identical Renal Transplantation.
R. Ossman,¹ M. Jamme,¹ P. Galichon,¹ A. Hertig,¹ B. Moulin,² C. Legendre,³ E. Morelon,⁴ J.-L. Taupin,⁵ L. Rostaing,⁶ E. Rondeau.¹
¹Urgences Néphrologiques et Transplantation, Hôpital Tenon, RADOVFULL Study Group, Université Pierre et Marie Curie, Paris, France; ²Néphrologie et Transplantation, Hôpital Civil, Strasbourg, France; ³Néphrologie et Transplantation, Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris, France; ⁴Néphrologie et Transplantation, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; ⁵Laboratoire d'Histocompatibilité, Hôpital Saint-Louis, Université Paris Diderot, Paris, France; ⁶Néphrologie et Transplantation d'Organes, Université Paul Sabatier, Toulouse, France
Purpose: We aimed to describe the immunosuppressive regimens and graft rejection rates in living-related HLA-identical (LR HLAid) renal transplantation.Methods: We performed a retrospective multicenter analysis…
2017 American Transplant Congress
Transplantation of Organs from Donors with Hepatitis C: The Potential to Substantially Increase Transplant Activity.
P. Trotter,^1,2 M. Robb,² I. Ushiro-Lumb,² J. Powell,³ C. Watson,¹ J. Bradley,¹ J. Neuberger.^2,4
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²Organ Donation and Transplantation, National Health Service Blood and Transplant, Bristol, United Kingdom; ³Hepatic-Pancreatico-Biliary Surgical Services and Edinburgh Transplant Unit, Royal Infirmary Edinburgh, Edinburgh, United Kingdom; ⁴The Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
Introduction. Organs from hepatitis C virus positive (HCV+ve) donors are commonly declined for transplantation because of the risk of disease transmission, but new direct acting…
2017 American Transplant Congress
Mutations in Influenza A Virus and Clinical Implications in Transplant Recipients.
V. Ferreira,¹ A. Humar,¹ E. Cordero,² E. Blumberg,³ S. Husain,¹ J. Kalpoe,⁴ M. Multicenter Influenza Group, D. Kumar.¹
¹UHN, Toronto, Canada; ²REIPI, Seville, Spain; ³UPenn, Philadelphia; ⁴LUMC, Leiden, Netherlands
Background: Organ and hematopoietic stem cell transplant (HSCT) recipients are predisposed to complications of influenza infection and as such may constitute an important source of…
2017 American Transplant Congress
Clinical Risk Factors for Bronchiolitis Obliterans Syndrome (BOS) in Lung Transplant Recipients (LTRs): Results of an International Cohort Study.
N. Law,¹ B. Hamandi,¹ C. Fegbeutel,² F. Silveira,³ E. Verschuuren,⁴ P. Ussetti,⁵ P. Chin-Hong,⁶ A. Solé,⁷ C.-L. Holmes-Liew,⁸ E. Billaud,⁹ P. Grossi,¹⁰ O. Manuel,¹¹ D. Levine,¹² R. Barbers,¹³ D. Hadjiliadis,¹⁴ L. Singer,¹ S. Husain.¹
¹University Health Network, Toronto, ON, Canada; ²Hannover Medical School, Hannover, Germany; ³University of Pittsburgh, Pittsburgh, PA; ⁴University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ⁵Hospital Puerta de Hierro, Madrid, Spain; ⁶University of California, San Francisco, CA; ⁷University and Polytechnic Hospital La Fe, Universidad de Valencia, Valencia, Spain; ⁸Royal Adelaide Hospital, Adelaide, Australia; ⁹APHP Hopital Européen G Pompidou, Paris, France; ¹⁰University of Insubria, Varese, Italy; ¹¹University Hospital of Lausanne, Lausanne, Switzerland; ¹²University of Texas Health Science Center San Antonio, San Antonio, TX; ¹³KECK Medical Center of University of Southern California, Los Angeles, CA; ¹⁴University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, PA
Introduction:Bronchiolitis obliterates syndrome (BOS) is a major impediment in the long term survival of LTRs. The main objective of this study was to identify infectious…
2017 American Transplant Congress
Results of the Initial Phase of the Portable Organ Care System (OCS™) Liver PROTECT Pivotal Trial.
J. Markmann,¹ M. Ghobrial,³ J. Magliocca,⁴ A. Demetris,⁵ M. Abouljoud.²
¹Department of Surgery-Division of Transplantation, Massachusetts General Hospital, Boston, MA; ²Transplant Institute and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ³Sherrie & Alan Conover Center for Liver Disease & Transplantation, Houston Methodist Hospital, Houston, TX; ⁴Division of Transplant Surgery Department of Surgery, The Emory Transplant Center, Atlanta, GA; ⁵Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
PurposeThe OCS Liver PROTECT Trial is a prospective, international, randomized controlled trial to evaluate the impact of using portable ex-vivo warm, oxygenated blood perfusion using…
2017 American Transplant Congress
The TAKE-IT Intervention Improves Medication Adherence in Adolescent Kidney Transplant Recipients.
B. Foster,¹ A. Pai,² S. Furth,³ TAKE-IT Investigators.
¹McGill University, Montreal, Canada; ²Cincinnati Children's Hospital Medical Center, Cincinnati; ³Children's Hospital of Philadelphia, Philadelphia
Poor adherence to immunosuppressive medications limits renal allograft survival. This randomized controlled trial, evaluated whether young kidney transplant recipients administered a behavioral intervention showed greater…
2017 American Transplant Congress
Donor-Derived Cell-Free DNA Correlates with Antibody-Mediated Rejection in Kidney Allografts.
R. Bloom,¹ J. Bromberg,² E. Poggio,³ D. Hiller,⁴ R. Woodward,⁴ J. Sninsky,⁴ J. Yee,⁴ D. Brennan.⁵
¹University of Pennsylvania, Philadelphia, PA; ²University of Maryland, Baltimore, MD; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵Washington University, St. Louis, MO
Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive test of allograft injury that may enable more frequent, quantitative, and safer assessment of allograft rejection and…
2017 American Transplant Congress
U.S. Outcomes in Early Liver Transplantation for Alcoholic Hepatitis: Results from the American Consortium of Early Liver Transplantation for Alcoholic Hepatitis (ACCELERATE-AH).
B. Lee,¹ N. Mehta,¹ L. Platt,² G. Im,³ G. Therapondos,⁴ H. Han,⁵ D. Victor,⁶ D. Dronamraju,⁷ I. Hanouneh,⁸ M. Voigt,⁹ M. Rinella,¹⁰ S. Eswaran,¹¹ J. Hause,¹¹ C. Hsu,¹² J. Dodge,¹ Z. Li,² N. Terrault.¹
¹UCSF, SF; ²Johns Hopkins, Baltimore; ³Mt Sinai, NYC; ⁴Ochsner, New Orleans; ⁵USC, LA; ⁶Houston Methodist, Houston; ⁷Maryland, Baltimore; ⁸Cleveland Clinic, Cleveland; ⁹Iowa, Iowa City; ¹⁰Northwestern, Chicago; ¹¹Rush, Chicago; ¹²UPenn, Philadelphia
INTRODUCTIONA Franco-Belgian protocol showed that early liver transplant (LT) in severe alcoholic hepatitis (AH) could improve survival with low incidence of alcohol relapse (AR). Application…
2017 American Transplant Congress
Tissue Transcriptional Profile of Portal Inflammation with Interface Activity in Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests Closely Resembles T Cell Mediated Rejection (TCMR).
A. Sanchez-Fueyo, S. Feng, A. Demetris, J. Bucuvalas, J. Lozano, J. Magee, K. Spain, S. Kanaparthi, iWITH Investigators.
KCL, London, United Kingdom; UCSF, SF; Pittsburgh, Pittsburgh; Cincinnati, Cincinnati; CiberEHD, Barcelona, Spain; Michigan, Ann Arbor; Rho, Chapel Hill; ITN, Bethesda; NIDDK/NIAID/NIH, Bethesda
Background: Significant inflammation±fibrosis is frequently seen in biopsies (bxs) of pediatric LT recipients with normal liver tests assessed for immunosuppression withdrawal. The pathogenesis of these…