ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Monitoring"

  • 2017 American Transplant Congress

    Donor-Derived Cell-Free DNA Normal Range and Biological Variation Defined in a Reference Population.

    J. Bromberg,1 D. Brennan,2 E. Poggio,3 D. Hiller,4 R. Woodward,4 J. Yee,4 J. Sninsky,4 R. Bloom.5

    1University of Maryland, Baltimiore, MD; 2Washington University, St. Louis, MO; 3Cleveland Clinic, Cleveland, OH; 4CareDx, Brisbane, CA; 5University of Pennsylvania, Philadelphia, PA

    Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the circulating blood of transplant recipients has shown promise as a non-invasive biomarker of acute rejection. This analysis was…
  • 2017 American Transplant Congress

    NK Cells Respond to CMV Lysate by Inducing IFNγ and CD107a Surface Expression in an Antibody-Dependent Manner: This Represents a Cytokine Flow Cytometry (CFC) Assay That Could Assess Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) as a Marker of CMV Immunity in Transplant Recipients.

    S. Ge, C. Maggie, B.-H. Shin, A. Karasyov, S. Jordan, M. Toyoda.

    Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    Background: Viral infections represent significant morbidity factors for transplant recipients. Tools to assess the efficacy of viral-specific responses are lacking. ADCC is the major antibody-mediated…
  • 2017 American Transplant Congress

    Identification of Promising Targets for Tolerance Induction Following Heart Transplantation.

    K. Klaeske, M.-T. Dieterlen, J. Fischer, J. Hahn, K. Jawad, J. Garbade, F. Mohr, S. Lehmann.

    Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany

    Introduction: Tolerance-inducing cell subsets which can support the organ acceptance following heart transplantation (HTx) can be found among dendritic cells (DCs) and regulatory T cells…
  • 2017 American Transplant Congress

    Noninvasive Renal Transplant Graft Monitoring in Single Institution Using Cell-Free DNA in Recipient Plasma via Insertion-Deletion Allele Polymorphism.

    Y. Goh,1 S. Ho,2 L. Raman,1 V. Anantharaman,3 T. Goh,3 S. Koay,2 H. Tiong.1

    1Urology, National University Hospital, Singapore, Singapore; 2Laboratory Medicine, National University Hospital, Singapore, Singapore; 3Nephrology, National University Hospital, Singapore, Singapore

    IntroductionThere is an unmet clinical need in renal transplantation towards early detection of donor organ damage. Serum creatinine(SCr) and biopsies are not ideal.Cell-free donor DNA(cfdDNA)…
  • 2017 American Transplant Congress

    Rejection of Human Kidney Allografts According to BANFF Classification Is Associated with a Chemokine-Enriched Protein Microenvironment in Biopsy Tssue.

    C. Falk,1 K. Daemen,1 J. Keil,1 F. Lehner,2 H. Haller,3 J. Schmitz,4 J.-H. Bräsen,4 C. Blume.5

    1Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; 2Department of Abdominal, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany; 3Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; 4Institute of Pathology, Hannover Medical School, Hannover, Germany; 5Institute for Technical Chemistry, Leibniz University, Hannover, Germany

    Background: Expression profiling efforts of biopsy tissue after kidney transplantation indicate that rejection can be defined by distinct signatures. Based on pathological evaluation (BANFF) as…
  • 2017 American Transplant Congress

    Association with Tacrolimus Intraindividual Variability, Acute Microinflammation Based on 1 Year-Transplanted Kidney Biopsy After Transplantation, and Biopsy-Proven Acute Rejection.

    S.-Y. Kim, S.-I. Min, W. Cho, S. Cho, M.-J. Cho, S. Ahn, S.-K. Min, J. Ha.

    Surgery, Seoul National University College of Medicine, Seoul, Korea

    Background: The purpose of this study was to investigate relationship between tacrolimus intraindividual variability (IIV), acute microinflammation (AMI) based on 1 year-transplanted kidney biopsy, and…
  • 2017 American Transplant Congress

    A Novel, Dose-Adjusted Tacrolimus Trough Concentration (TTC) Model for Prediction and Variance Estimation.

    J. Kim,1 S. Wilson,1 N. Undre,2 S. Fei,1 R. Kristy,1 J. Schwartz.1

    1Astellas Pharma Global Development, Inc., Northbrook, IL; 2Astellas Pharma Global Development, Inc., Chertsey, United Kingdom

    Given that a high tacrolimus (tac) intrapatient variability (IPV) increases the risk for a poor kidney transplant (tx) outcome, some experts advocate routine IPV monitoring…
  • 2017 American Transplant Congress

    Prospective Randomized Trial for Predicting CMV Infection According to Baseline CMV-Specific T-Cell Immunity in Kidney Transplant Patients.

    M. Jarque,2 E. Melilli,1 A. Gutierez,3 F. Moreso,4 L. Guirado,5 A. Manonelles,1 J. Cruzado,1,2 S. Luque,2 E. Crespo,2 N. Montero,1 F. Diekman,6 J. Grinyó,1,2 O. Bestard.1

    1Nephrology Dep, Bellvitge Hospital, Barcelona, Spain; 2Nephrology Laboratory, IDIBELL, Barcelona, Spain; 3Kidney Transplant Unit, Hospital Miguel Servet, Zaragoza, Spain; 4Kidney Transplant Unit, Hospital Vall d'Hebrón, Barcelona, Spain; 5Kidney Transplant Unit, Fundació Puigvert, Barcelona, Spain; 6Kidney Transplant Unit, Hospital Clínic, Barcelona, Spain

    Background: Despite the use of either anti-viral prophylaxis (PF) or preemptive (PE) therapy given based on donor/recipient IgG-serostatus, Cytomegalovirus (CMV) reactivation persists after kidney transplantation…
  • 2017 American Transplant Congress

    Persistence/Progression of Early Banff Borderline Changes (BBC) Is Associated with Chronic Renal Allograft Damage and Can Be Predicted by B Cell Cytokine Profile.

    A. Cherukuri, A. Sharma, R. Mehta, S. Hariharan, D. Rothstein.

    UPMC, Pittsburgh

    The clinical significance of early histological BBC in kidney transplant recipients (KTR) is unclear. It is also unknown if biomarkers predict progression to acute rejection…
  • 2017 American Transplant Congress

    Pre-Transplant CMV-Specific T-Cell Immunity Is an Additional Independent Variable Predicting CMV Infection After Kidney Transplantation.

    E. Crespo,1 M. Jarque,1 S. Luque,1 E. Melilli,2 A. Manonelles,2 S. Gil-Vernet,2 J. Cruzado,2 J. Grinyó,2 O. Bestard.2

    1Nephrology Laboratory, IDIBELL, Barcelona, Spain; 2Kidney Transplant Unit, Bellvitge University Hospital, Barcelona, Spain

    Background: Current pre-transplant risk stratification for Cytomegalovirus (CMV) infection is based on donor/recipient (D/R) IgG-serostatus and clinical variables such as the use of T-cell depletion…
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