2018 American Transplant Congress
Origin and Pattern of Human Polyomaviruses Replication after Kidney Transplantation: A Prospective Study
Background. Human Polyomaviruses (HPyVs) are able to establish latent infection in the kidney of the host. Immunosuppression is recognized risk factor for HPyVs reactivation. Besides…2018 American Transplant Congress
A Novel Combined Formula to Direct Optimal Immunosuppressive Drug Exposure in Renal Transplant Recipients
Purpose: The most widely used maintenance immunosuppressive combination after kidney transplantation is tacrolimus (TAC) and mycophenolic acid (MPA). The utility of therapeutic drug monitoring for…2018 American Transplant Congress
Unbiased Sequencing of Urine Cell-Free DNA (cfDNA) to Evaluation Urine Virome and Associated Renal Allograft Damage
Intro: Virus reactivation leading to graft damage is a frequent post-kidney transplant (KTx) complication. Immunosuppressed individuals are at risk for multiple virus infections simultaneously. Current…2017 American Transplant Congress
Cytomegalovirus Viral Load: Characterization of Results from Clinical Specimens.
Viracor Eurofins, Lees Summit, MO
Cytomegalovirus (CMV) infection, a frequent complication affecting solid organ and hematopoietic stem cell transplant recipients, is commonly diagnosed and monitored by quantitative PCR (qPCR) methods.…2017 American Transplant Congress
A Novel Microsurgical Penis Transplant Model to Study Distinct Immunologic Features of Urogenital Tissues.
Johns Hopkins University, Baltimore, MD
Background: Penis transplantation has been successfully employed in the recent past and represents an exciting avenue for restoration of male urogenitalia and function by using…2017 American Transplant Congress
Donor-Derived Cell-Free DNA Is a Dynamic Biomarker of Active Rejection in Kidney Allografts.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) has shown promise as a biomarker in identification of allograft rejection. Here we report on the changes in dd-cfDNA prior…2017 American Transplant Congress
Donor-Derived Cell-Free DNA Normal Range and Biological Variation Defined in a Reference Population.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the circulating blood of transplant recipients has shown promise as a non-invasive biomarker of acute rejection. This analysis was…2017 American Transplant Congress
NK Cells Respond to CMV Lysate by Inducing IFNγ and CD107a Surface Expression in an Antibody-Dependent Manner: This Represents a Cytokine Flow Cytometry (CFC) Assay That Could Assess Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC) as a Marker of CMV Immunity in Transplant Recipients.
Background: Viral infections represent significant morbidity factors for transplant recipients. Tools to assess the efficacy of viral-specific responses are lacking. ADCC is the major antibody-mediated…2017 American Transplant Congress
Identification of Promising Targets for Tolerance Induction Following Heart Transplantation.
Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
Introduction: Tolerance-inducing cell subsets which can support the organ acceptance following heart transplantation (HTx) can be found among dendritic cells (DCs) and regulatory T cells…2017 American Transplant Congress
Noninvasive Renal Transplant Graft Monitoring in Single Institution Using Cell-Free DNA in Recipient Plasma via Insertion-Deletion Allele Polymorphism.
IntroductionThere is an unmet clinical need in renal transplantation towards early detection of donor organ damage. Serum creatinine(SCr) and biopsies are not ideal.Cell-free donor DNA(cfdDNA)…
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