2018 American Transplant Congress
Clinically Relevant Variation of Donor-Derived Cell-Free DNA during Longitudinal Surveillance of Renal Allografts
Purpose: Donor-derived cell-free DNA (dd-cfDNA) levels >1% are associated with active rejection in renal transplant recipients. This report defines the clinically relevant variation of dd-cfDNA…2018 American Transplant Congress
Estimation of Beta Cell Function after Total Pancreatectomy with Islet Autotransplantation Using Single Fasting Blood Sample Based Indices and Modified Igls Score.
Background: For precise yet logistically feasible evaluation of beta-cell function after total pancreatectomy with islet autotransplantation (TPIAT), we investigated the utility of indices using only…2018 American Transplant Congress
Four Eyes Are Better Than Two: Improving Laboratory Report Quality Control
1Quality Assurance, LABS, Inc., Centennial, CO; 2Infectious Disease, LABS, Inc., Philadelphia, PA.
Background: Our STAT donor-screening lab implemented a new LIMS that is used to manage patient orders, testing and reporting. We intentionally customized the LIMS to…2017 American Transplant Congress
Association with Tacrolimus Intraindividual Variability, Acute Microinflammation Based on 1 Year-Transplanted Kidney Biopsy After Transplantation, and Biopsy-Proven Acute Rejection.
Surgery, Seoul National University College of Medicine, Seoul, Korea
Background: The purpose of this study was to investigate relationship between tacrolimus intraindividual variability (IIV), acute microinflammation (AMI) based on 1 year-transplanted kidney biopsy, and…2017 American Transplant Congress
A Novel, Dose-Adjusted Tacrolimus Trough Concentration (TTC) Model for Prediction and Variance Estimation.
Given that a high tacrolimus (tac) intrapatient variability (IPV) increases the risk for a poor kidney transplant (tx) outcome, some experts advocate routine IPV monitoring…2017 American Transplant Congress
Prospective Randomized Trial for Predicting CMV Infection According to Baseline CMV-Specific T-Cell Immunity in Kidney Transplant Patients.
Background: Despite the use of either anti-viral prophylaxis (PF) or preemptive (PE) therapy given based on donor/recipient IgG-serostatus, Cytomegalovirus (CMV) reactivation persists after kidney transplantation…2017 American Transplant Congress
Persistence/Progression of Early Banff Borderline Changes (BBC) Is Associated with Chronic Renal Allograft Damage and Can Be Predicted by B Cell Cytokine Profile.
The clinical significance of early histological BBC in kidney transplant recipients (KTR) is unclear. It is also unknown if biomarkers predict progression to acute rejection…2017 American Transplant Congress
Pre-Transplant CMV-Specific T-Cell Immunity Is an Additional Independent Variable Predicting CMV Infection After Kidney Transplantation.
Background: Current pre-transplant risk stratification for Cytomegalovirus (CMV) infection is based on donor/recipient (D/R) IgG-serostatus and clinical variables such as the use of T-cell depletion…2017 American Transplant Congress
Impact of mTOR-Inhibition on Tolerance-Induction Following Heart Transplantation.
Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
Introduction: The mammalian target of rapamycin (mTOR) is a central regulator of the immune system and therefore one target of immunosuppressive drug therapy. Tolerance-inducing properties…2017 American Transplant Congress
Donor-Derived Cell-Free DNA Correlates with Antibody-Mediated Rejection in Kidney Allografts.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive test of allograft injury that may enable more frequent, quantitative, and safer assessment of allograft rejection and…
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