Articles tagged "Mixed chimerism"

2016 American Transplant Congress
Generation of Naïve Donor-Derived Lymphocytes from Graft-Resident Lymphoid Progenitors After Human Intestinal Transplantation.
J. Fu, J. Zuber, B. Shonts, S. Lau, A. Obradovic, T. Savage, M. Simpson, S. Yang, Y. Shen, M. Martinez, A. Griesemer, T. Kato, M. Sykes.
Columbia University, New York.
Multivisceral transplantation (MVTx) is associated with a lower rate of severe graft rejection than isolated intestinal transplantation (iITx). We recently demonstrated that mixed T cell…
2016 American Transplant Congress
HLA Identical or Haploidentical Combined Kidney and Bone Marrow Transplantation for Multiple Myeloma with End-Stage Renal Failure.
T. Kawai,¹ Y.-B. Chen,¹ M. Sykes,² C. Benedict,¹ N. Tolkoff-Rubin,¹ B. Day,¹ S. McAfee,¹ K. Ballen, S. David,¹ T. Spitzer.¹
¹Massachusetts General Hospital, Boston; ²Columbia University, New York.
Patients with multiple myeloma (MM) who developed end-stage renal disease (ESRD) are generally not eligible for either kidney transplantation or allogeneic stem-cell transplant. We performed…
2016 American Transplant Congress
Long-Lasting Skin Allograft Tolerance Induced and Maintained by Short-Term Vascularized Bone Marrow Transplant in a Mouse Model.
C.-H. Lin,¹ M. Anggelia,¹ H.-Y. Cheng,¹ Y.-L. Wang,¹ W.-Y. Chuang,¹ C.-H. Lin,¹ G. Brandacher.²
¹Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD.
Background: Accumulating evidences indicate that vascularized bone marrow transplantation (VBMT) plays a critical role in inducing tolerance of vascularized composite allografts (VCA). Recipients with long-term…
2016 American Transplant Congress
Post Transplantation High-Dose Cyclophosphamide Treatment Promotes Immune Tolerance After Skin, Solid Organ, and Vascularized Composite Allotransplantation.
G. Furtmüller,¹ B. Oh,¹ M. Fryer,^1,4 P. Akre,¹ S. Ganguly,² J. Dodd-o,³ D. Cooney,¹ G. Raimondi,¹ W. Lee,¹ L. Luznik,² G. Brandacher.¹
¹Department of Plastic and Reconstructive Surgery, Johns Hopkins Medicine, Baltimore, MD; ²Immunology - Sydney Kimmel Cancer Center, Johns Hopkins Medicine, Baltimore, MD; ³Department of Anesthesiology, Johns Hopkins Medicine, Baltimore, MD; ⁴Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA.
Background: Developing novel approaches to minimize/avoid immunosuppression by induction of immune tolerance represents the prime task in the field of transplantation. Methods: Murine skin, heart,…
2015 American Transplant Congress
Combined Bone Marrow Plus Liver Transplantation in Cynomolgus Monkeys
J. Weiner, Y. Kato, R. Duran-Struuck, M. Martinez, S. Baker, P. Alonso, J. Zitsman, A. Wu, P. Houck, T. Pinyavat, J. Lefkowitch, S. Chaudhry, T. Kato, M. Sykes, A. Griesemer.
Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
IntroductionCombined kidney/bone marrow transplantation (CKBMT) induces tolerance in both primates and humans. Since liver is thought to be more tolerogenic than kidney, we hypothesized that…
2015 American Transplant Congress
Chimerism for Early Detection of Graft Versus Host Disease in Intestinal Transplantation
J. Garcia, T. Beduschi, P. Ruiz, A. Tekin, J. Fan, S. Nishida, G. Selvaggi, L. Cubley, R. Vianna.
Miami Transplant Institute, University of Miami Miller School of Medicine, Miami, FL.
Graft versus host disease (GVHD) is a potentially fatal complication after multivisceral transplantation (MVT). By definition, donor cells must be present in the blood of…
2015 American Transplant Congress
Kidney Versus Islet Allograft Survival After Induction of Mixed Chimerism in Nonhuman Primates
T. Oura, D. Ko, J. O'Neil, S. Boskovic, O. Nadazdin, K. Hotta, K. Kawai, B. Cosimi, T. Kawai.
Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Background: We have previously reported a successful induction of mixed chimerism and the long-term acceptance of renal allografts in MHC-mismatched nonhuman primates. In this study,…
2015 American Transplant Congress
T Cell Transfer With iNKT Cell Activation Facilitate Engraftment of Bone Marrow Cells Without GvHD
R. Ishii,¹ T. Hirai,¹ S. Miyairi,¹ M. Ikemiyagi,¹ K. Omoto,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Laboratory of Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
Contamination of allogenic T cells is considered to be a risk factor of graft versus host disease (GvHD) in bone marrow transplantation (BMT), whereas it…
2015 American Transplant Congress
Rejection of an Allograft Through Non-MHC Antigens Does Not Translate to the Rejection of a Different Allograft from the Same Donor in Mixed Chimeras
K. Shinoda,¹ C. Chase,¹ P. Russell,¹ J. Madsen,¹ R. Colvin,² A. Alessandrini.¹
¹Transplant Center, Massachusetts General Hospital, Boston, MA; ²Pathology, Massachusetts General Hospital, Boston, MA.
We previously showed that tolerance, induced by mixed chimerism in mice, is antigen-specific: tolerance of heart and skin allografts is dependent on Foxp3+ cells that…
2015 American Transplant Congress
Regulatory T Cells Expanded by Activated iNKT Cells Facilitate Migration of Donor Dendritic Cells Into the Recipient Thymus and Subsequent Establishment of Clonal Deletion
T. Hirai,¹ R. Shibahara,¹ S. Miyairi,¹ M. Ikemiyagi,¹ K. Omoto,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Laboratory for Vaccine Design, RINEK Center for IMS, Yokohama, Japan.
We previously reported that combination therapy using liposomal α-galactosylceramide (lipo-αGC) and anti-CD154 mAb could expand regulatory T cells (Tregs) in vivo through activation of the…