Articles tagged "Mixed chimerism"

2017 American Transplant Congress
Induction of Tolerance to Renal Allografts in Non Human Primates by Concomitant Donor-Matched Vascularized Osteomyocutaneous Allotransplantation.
F. Zhong,¹ G. Zhao,² Y. Wang,³ J. Jiang,³ Y. Wang,¹ S. Ye,¹ S. Tao,¹ L. Cai,¹ X. Wang,¹ Q. Ye,¹ G. Chen,² X. Zheng.¹
¹Center for Transplantation Medicine, Wuhan University Zhongnan Hospital, Wuhan, Hubei, China; ²Transplantation, Tongji Hospital, Wuhan, Hubei, China; ³Surgery, Shanghai Dongfan Hospital, Shanghai, China
Introduction: We hypothesized that hematopoietic stem cell (HSC) niches in bone marrow of vascularized osteomyocutaneous allografts (VOMA) will facilitate mixed chimerism (MC) and tolerance to…
2016 American Transplant Congress
Tolerogenic Interactions Between Host CD8⁺Myeloid Dendritic Cells and Natural Killer T Cells Are Required for Acceptance of Combined Organ and Bone Marrow Transplants After TLI Conditioning.
D. Hongo Apum,¹ X. Zhang,² E. Engleman,² S. Strober.¹
¹Medicine - Division of Immunology & Rheumatology, Stanford University, Stanford, CA; ²Medicine - Department of Pathology, Stanford University, Stanford, CA.
Combined transplantation of solid organs and bone marrow or hematopoietic progenitor cells has resulted in successful achievement of tolerance in both laboratory animals and in…
2016 American Transplant Congress
Developing a PCR-Based System to Access the Correlation of Local Chimerism and Fate of the Vascularized Composite Allotransplant.
X.-T. Huang,¹ H.-Y. Cheng,¹ C.-F. Lin,¹ S.-S. Qiu,² L.-Y. Shih,¹ F.-C. Wei.^1,2,3
¹Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Gueishan, Taoyuan, Taiwan; ²Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Gueishan, Taoyuan, Taiwan; ³College of Medicine, Chang Gung University, Gueishan, Taoyuan, Taiwan.
It is established that development of mixed chimerism following allotransplantation is associated with induction of tolerance to allotransplants. Although chimerism in peripheral blood can be…
2016 American Transplant Congress
iNKT Cell Activation Under Co-Stimulatory Blockade Establishes Mixed Chimerism Through Thymic Regulatory T Cell Activation.
T. Hirai,¹ Y. Ishii,² R. Ishii,¹ S. Miyairi,¹ M. Ikemiyagi,¹ M. Okumi,¹ K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan; ²Laboratory for Vaccine Design, RIKEN-IMS, Yokohama, Kanagawa, Japan.
Background: Invariant natural killer T (iNKT) cells have recently garnered considerable attention for their potential to induce regulatory T cells (Tregs). We previously reported a…
2016 American Transplant Congress
Impact of Mixed Xenogeneic Chimerism on Human B Cell Response to Pig Antigens.
H. Li, S. Shao, P. Vishwasrao, M. Holzl, M. Sykes.
Columbia Center for Translational Immunology, Columbia University, New York, NY.
Xenotransplantation is a potential solution to the organ shortage in clinical transplantation. Pigs are regarded as the most suitable donors. Studies in pig-to-nonhuman primates have…
2016 American Transplant Congress
The Function of CD8⁺TCR^– Facilitating Cells and Regulatory T Cells Is Impaired in Flt3-Ligand Knockout Mice.
Y. Huang, H. Xu, T. Miller, Y. Wen, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Graft CD8+TCR- facilitating cells (FC) enhance engraftment of hematopoietic stem cells (HSC) in allogeneic mouse recipients without causing graft-versus-host disease. FC induce antigen-specific CD4+CD25+FoxP3+ regulatory…
2016 American Transplant Congress
Contrasting Effects of Tacrolimus and Everolimus on Regulatory T Cell Activation and Mixed Hematopoietic Chimerism Induced by Natural Killer T Cell Stimulation.
S. Miyairi,^1,2 T. Hirai,¹ R. IShii,¹ M. Okumi,¹ Y. Ishii,³ S. Nunoda,² K. Yamazaki,² K. Tanabe.¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan; ³Laboratory of Vaccine Design, RIKEN IMS-RCAI, Yokohama, Japan.
Calcineurin (CN)-dependent IL-2 production is crucial for regulatory T cells (Tregs) to demonstrate suppressive activity. The mTOR signal is not required for Treg function because…
2016 American Transplant Congress
Delaying the Induction of Mixed Chimerism Until Two Months After NHP Heart and Kidney Cotransplantation Results in Long Term Survival.
K. Huh,¹ M. Tonsho,¹ P. Spencer,¹ J. Paster,¹ X. Wu,¹ I. Hanekamp,¹ T. Kawai,^1,3 R. Smith,² A. Cosimi,¹ A. Dehnadi,¹ G. Benichou,¹ R. Colvin,^1,2 J. Madsen.^1,4
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA; ³Department of Surgery, Massachusetts General Hospital, Boston, MA; ⁴Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.
Background. We have previously achieved delayed tolerance in cynomologous recipients cotransplanted with heart and kidney allografts by treating recipients with standard triple drug immunosuppression for…
2016 American Transplant Congress
Immune Tolerance Monitoring in Renal Allograft Tolerance Induced by Transient Mixed Chimerism in Nonhuman Primates and Humans.
K. Hotta, T. Oura, K. Crisalli, D. Sachs, B. Cosim, T. Kawai.
Center for Transplantation Science, Massachusetts General Hospital, Boston, MA.
Background: Successful induction of allograft tolerance in MHC-mismatched kidney transplantation has been achieved after induction of transient chimerism in both nonhuman primates (NHP) and humans.…
2016 American Transplant Congress
IL-10 Expression of In Vitro Activated B Cells as A Biomarker for B Cell Tolerance.
T. Oura, K. Hotta, K. Crisalli, B. Cosimi, T. Kawai.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Background: A significant role for regulatory B cell has been suggested in kidney transplant recipients who achieved operational tolerance while receiving conventional immunosuppression. We studied…