2019 American Transplant Congress
The Effects of Chronic Kidney Disease on Antiviral T Cell Response
*Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). Cytomegalovirus (CMV) establishes…2019 American Transplant Congress
mTORC2 Restricts mTORC1 Metabolic Function in Dendritic Cells to Limit Their Allostimulatory Activity
*Purpose: Mechanistic target of rapamycin complex 2 (TORC2) deficiency in conventional dendritic cells (DC) results in their enhanced pro-inflammatory and T cell allostimulatory activity; however,…2019 American Transplant Congress
Tubastatin-A, an HDAC6 Inhibitor, is Protective in Liver Ischemia Reperfusion Injury and Acetaminophen-Mediated Liver Injury
*Purpose: Ischemia reperfusion injury (IRI) causes morbidity and contributes to early graft loss in liver transplantation and no current therapy exists. Liver injury complicates other…2019 American Transplant Congress
Graft Perfusion with Alvespimycin, an HSP90 Inhibitor, Suppresses IL-2 and IL-12p40 Production in Graft-Infiltrating Cells, Leading to Prolongation of Graft Survival in Murine Heart Transplantation
Department of Urology, Sapporo Medical University, Sapporo, Japan
*Purpose: We have previously demonstrated that administration of a heat shock protein 90 (HSP90) inhibitor prolonged the allograft survival in murine skin and heart transplantations.…2019 American Transplant Congress
Kupffer Cells Are Critical for Inflammation Resolution in Liver Ischemia Reperfusion Injury via TIM-4 Mediated Efferocytosis
*Purpose: Liver ischemia reperfusion injury (IRI) remains a clinical problem associated with both surgical and non-surgical settings. Innate immune-dominated inflammation drives the pathogenesis of liver…2019 American Transplant Congress
Histone Deacetylase-2 Knockout in Renal Tubular Cells is Protective in Renal Ischemia-Reperfusion Injury
*Purpose: Ischemia-reperfusion injury (IRI) is a major source of morbidity in renal transplantation and is without targeted therapy. In renal transplantation, IRI contributes to poorer…2019 American Transplant Congress
Fractalkine is Crucial in Ischemia Reperfusion Injury Related to Acute Rejection in an Allogeneic Heart Transplantation Model
1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2KAN Research Institute, Kobe, Japan
*Purpose: Ischemia reperfusion injury (IRI) facilitates allograft rejection in renal transplantation recipients (IRI-related rejection). Controlling IRI improves graft survival. Fractalkine (FKN) is an inflammatory chemokine.…2019 American Transplant Congress
TDCA/Valine Reverse Obesity and Ameliorate Alloimmune Responses through a Decreased Hypothalamic Expression of MCH
1Brigham and Women's Hospital, Boston, AL, 2Beth Israel Deaconess Medical Center, Boston, AL
*Purpose: Obesity is associated with low grade inflammation and bariatric surgery is the only effective treatment in reducing excess weight both pre- and post-transplant.*Methods: Here,…2019 American Transplant Congress
Stabilization of Cell Junctions Ameliorates the Effects of Brain Death Induced Acute Lung Injury Post-Transplantation
*Purpose: Donor Brain death (BD) induces acute lung injury (BD-ALI), characterized by the breakdown of endo/epithelial barrier functions. These injuries are further exacerbated by ischemia…2019 American Transplant Congress
Patterns of Rejection in Murine, Porcine, and Human Vascularized Composite Allografts Based on Clinical, Histologic, and Immunohistochemical Analysis
Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: The side effects of chronic immunossupression limit the more extensive use of Vascularized Composite Allotransplantation (VCA), and because reliable pre-clinical animal models will be…
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