2020 American Transplant Congress
Aging Aggravated Liver Ischemia and Reperfusion Injury by Promoting Sting-Mediated NLRP3 Activation in Macrophages
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Aggravated liver injury and enhanced intrahepatic inflammation was found in old livers post ischemia and reperfusion (IR). However, the function and underlying mechanism of…2020 American Transplant Congress
Role of Innate Allorecognition Pathways in Mouse Kidney and Heart Allograft Rejection
*Purpose: Paired immunoglobulin-like receptors (PIR) and CD47 are molecules expressed on host myeloid cells. They recognize donor polymorphic MHC and signal regulatory protein alpha (SIRPα),…2020 American Transplant Congress
Contamination of Acinar Cells Impairs Therapeutic Effect of Islet Transplantation Due to Induction of Inflammatory Reaction in Not Only Graft Islets but Also Hepatic Parenchyma
Regenerative Medicine and Transplantation, Fukuoka University, Fukuoka City, Japan
*Purpose: Islet transplantation is a promising treatment option for type 1 diabetes. Edmonton protocol recommended that over 30 % purity of islets is essential for…2020 American Transplant Congress
HMGB1 Antagonizes the Immunosuppressive Effect of MSCs in AKI
*Purpose: Kidney ischemia reperfusion injury (IRI) is a common cause of acute kidney injury and an unavoidable consequence of kidney transplantation and still lacks specific…2020 American Transplant Congress
Liver Plasmacytoid Dendritic Cells Express High Levels of DAP12, TREM2 and PD-L1 and Promote Effector T Cell Exhaustion and Augmented Treg Responses in Spontaneous Liver Transplant Tolerance
University of Pittsburgh, Pittsburgh, PA
*Purpose: The precise mechanisms of liver transplant tolerance are yet to be elucidated. Non-conventional plasmacytoid dendritic cells (pDCs) are thought to promote immune regulation, including…2020 American Transplant Congress
Effect of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Induced Acute Kidney Injury in Mice
*Purpose: Livers with mild to moderate steatosis have been used to expand the donor pool for transplantation. However, livers with steatosis have a propensity for…2020 American Transplant Congress
Orthogonal IL-2 Cytokine-Receptor Pair Capable of Selective Expansion of Regulatory T Cells Facilitates Alloengraftment
*Purpose: Adoptive transfer of regulatory T cells (Tregs) has been shown to improve alloengraftment in animal models. However, ex vivo Treg expansion for the purpose…2020 American Transplant Congress
Treatment Strategies to Suppress Donor Specific Antibodies: Highlights from a Decade of Research Experience in a Mouse Model of Allo-Sensitization
Cedars-Sinai Med Ctr, Los Angeles, CA
*Purpose: Difficulty in desensitization in highly sensitized patients remain problematic in organ transplantation. For over 12 years, our laboratory has been carrying out an HLA…2020 American Transplant Congress
Long-Term Allograft Survival via Donor MHC Chimerism Induced by Exosomes
*Purpose: Allogeneic transplant tolerance has been achieved by inducing mixed hematopoietic chimerism via donor bone marrow transplantation. Tolerance mechanisms in this model involve the presentation…2020 American Transplant Congress
Graft Perfusion with an Hsp90 Inhibitor Prolongs Graft Survival in Murine Heart Transplantation by Modulating Expression of Cyclin-Dependent Kinases and the Senolytic Effect
Department of Urology, Sapporo Medical University, Sapporo, Japan
*Purpose: We have previously demonstrated that administration of alvespimycin, a heat shock protein 90 (HSP90) inhibitor, prolongs the allograft survival in murine skin and heart…
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