2016 American Transplant Congress
Expansion of Regulatory B-Cells and Their Potential Role in Transplantation Tolerance.
Massachusetts General Hospital, Boston, MA.
IntroductionRegulatory B (Bregs) cells, B cells which produce IL-10, have been shown to play a critical role in immune homeostasis and autoimmunity models. Despite the…2016 American Transplant Congress
Alloantibody Suppression by Bruton Tyrosine Kinase Antagonist Ibrutinib Is Associated with a Moderate Splenic B-Cell Reduction.
Comprehensive Transplantation Center/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Bruton tyrosine kinase (Btk) is specifically required for activation of the B-cell antigen receptor signaling pathway that contributes to the initiation and maintenance of…2016 American Transplant Congress
Activating Transcription Factor 5 (ATF5) Regulates Liver Ischemia/Reperfusion Injury.
Activating transcription factor 5 (ATF5), a member of the ATF/cAMP response element-binding proteins, is extremely highly expressed in the liver, the significance of which is…2016 American Transplant Congress
Transfer of Donor-Derived Exosomes to Recipient Ag-Presenting Cells Is Critical for Allograft Recognition.
After organ transplantation, T cells are primed against donor MHC molecules by donor dendritic cells (DCs) mobilized from the graft. Nevertheless, evidence suggests that donor…2016 American Transplant Congress
Impact of CXCR4/CXCL12 Blockade on Normal Plasma Cells In Vivo.
Department of Surgery, Division of Transplant Surgery, Mayo Clinic, Rochester, MN.
Introduction:Plasma cells (PCs) are a major source of alloantibody in transplant patients.They are resistant to current therapy. Since receptor/ligand interactions in the stromal environment are…2016 American Transplant Congress
Sphingosine-1 Phosphate Receptor 1 Agonist SEW2871 Ameliorates Hepatocellular Injury on Ischemic Reperfusion in Mice: A New Therapeutic Target.
Introduction: We had reported that activated protein C (APC) administration had cytoprotective effects on hepatic ischemic reperfusion (IR) injury in rat and mice models. Recent…2016 American Transplant Congress
mTORC2 Negatively Regulates Dendritic Cell (DC) Metabolism and the Allostimulatory Function of Donor DCs in Organ Transplantation.
The mechanistic target of rapamycin (mTOR) is a kinase that functions in at least two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play…2016 American Transplant Congress
Contributions of Naive vs. Endogenous and Induced Alloreactive Memory T Cells in Mixed Lymphocyte Reactions.
Surgery, MGH/Harvard Medical School, Boston, MA.
T lymphocytes isolated from naïve, unmanipulated mice, proliferate and secrete cytokines when cultured in vitro with allogeneic irradiated leukocytes. This in vitro response known as…2016 American Transplant Congress
Short-Term Starvation Attenuates Liver Ischemia Reperfusion Injury by SIRT1-Autophagy Signaling in Mice.
Calorie restriction or starvation (fasting) has some beneficial effects on prolongation of life and increased resistance to stress. Calorie restriction has also been shown to…2016 American Transplant Congress
Role of NRP1 in CD4+ T Cell Allo-Activation.
Department of Surgery, Boston Children's Hospital, Boston, MA.
Introduction: Neuropilin-1 (NRP1) is a transmembrane glycoprotein that functions as a co-receptor for class III/IV semaphorins, VEGF, and several other growth factors. NRP1 has been…
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