2022 American Transplant Congress
Rhesus-Primatized Mouse Model Generated Using Transgenic Immunodeficient Mice
1Surgery, University of Wisconsin, Madison, WI, 2University of Wisconsin, Madison, WI
*Purpose: To develop a translational primatized mouse model, akin to humanized mice, that allows for high-throughput in vivo experimentation to augment non-human primate pre-clinical studies.*Methods:…2022 American Transplant Congress
Immunomodulatory Effects of Probiotic Bifidobacterium Bifidum with Tacrolimus and Sirolimus in Mouse Skin Graft Model
*Purpose: Accumulating evidence suggests that gut microbiota actively crosstalks with the host immune system, and alterations of gut microbiota may exert immune regulatory effects. We…2022 American Transplant Congress
Donor Kidney-Resident Passenger Macrophages Promote CCL8-CCR8 Mediated Early Allograft Inflammation
*Purpose: Early intragraft infiltration of monocytes and macrophages has been associated with acute and chronic allograft rejections. Nevertheless, underlying mechanism remained poorly understood. In the…2022 American Transplant Congress
A Novel Method for Ex Vivo Stimulation of Mesenchymal Stem Cells via Invariant Natural Killer T Cell Activation with ɑ-galactosylceramide
*Purpose: Mesenchymal stem cells (MSCs) typically exhibit unique regenerative and immunomodulatory properties when exposed to proinflammatory cytokines. Invariant natural killer T (iNKT) cells are known…2022 American Transplant Congress
The Role of LAG3 in Antibody Responses to Kidney Transplantation
*Purpose: The functions of coinhibitory receptor lymphocyte activation gene-3 (LAG3) in T cells are well studied, however its role in humoral immune responses remains poorly…2022 American Transplant Congress
Absence of DAP12 Expression by Donor Liver-Derived Dendritic Cells Enhances Their Contact with T Cells in Host Secondary Lymphoid Tissue: Implications for Abrogation of MHC-mismatched Liver Transplant Tolerance in Mice
University of Pittsburgh, Pittsburgh, PA
*Purpose: Multiphoton intravital microscopy is a high-resolution, real-time, fluorescence imaging technique that enables study of interactions between cells in their native, 3-dimensional environment including organ…2022 American Transplant Congress
Natural vs Induced ABO Antibodies in a Murine Model: Role of Sex and T Cells
1University of Alberta, Edmonton, AB, Canada, 2University of Melbourne, Melbourne, Australia
*Purpose: Interaction of ‘natural’ ABO antibodies (nAbs) with their cognate AB(H)-antigens (Ags) poses a high risk of rapid rejection of ABO-incompatible (ABOi) organ transplants. We…2022 American Transplant Congress
Aquaporin 4 is a Mediator of Essential Dendritic Cell Functions
*Purpose: Aquaporins are a family of transmembrane water channels implicated in a broad range of physiological functions. We previously reported that Aquaporin 4 (AQP4) is…2022 American Transplant Congress
Marginal Zone B Cells Support T Cell Reconstitution Following ATG Lymphoablation in Heart Allograft Recipients.
Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Lymphoablation with anti-thymocyte globulin (ATG) is a common therapy in solid organ transplantation. However homeostatic proliferation of pre-existing memory T cells undermines the graft-prolonging…2022 American Transplant Congress
Iguratimod Alleviates Endothelial to Mesenchymal Transition by Inducing AMBRA1/PARKIN-Dependent Mitophagy and Inhibiting NLRP3 Activation During Renal Allograft Interstitial Fibrosis
*Purpose: Chronic renal graft dysfunction (CAD) is caused by multiple factors, including glomerular sclerosis, inflammation, interstitial fibrosis and tubular atrophy (IF/TA). However, the most prominent…
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