ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2022 American Transplant Congress

    Marginal Zone B Cells Support T Cell Reconstitution Following ATG Lymphoablation in Heart Allograft Recipients.

    Y. Yamamoto, R. Fan, M. Nicosia, V. Gorbacheva, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH

    *Purpose: Lymphoablation with anti-thymocyte globulin (ATG) is a common therapy in solid organ transplantation. However homeostatic proliferation of pre-existing memory T cells undermines the graft-prolonging…
  • 2022 American Transplant Congress

    Iguratimod Alleviates Endothelial to Mesenchymal Transition by Inducing AMBRA1/PARKIN-Dependent Mitophagy and Inhibiting NLRP3 Activation During Renal Allograft Interstitial Fibrosis

    Z. Gui1, W. Zijie2, M. Zheng3, R. Tan3, M. Gu4

    1Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China, 2Jiangsu Province Hospital, Nanjing, China, 3Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China, 4Department of Urology, the Second Affiliated Hospital with Nanjing Medical University, Nanjing, China

    *Purpose: Chronic renal graft dysfunction (CAD) is caused by multiple factors, including glomerular sclerosis, inflammation, interstitial fibrosis and tubular atrophy (IF/TA). However, the most prominent…
  • 2022 American Transplant Congress

    Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury

    V. Gorbacheva, R. Fan, S. Miyairi, W. M. Baldwin, R. Fairchild, A. Valujskikh

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Immune responses to self antigens develop following organ transplantation. Multiple studies describe correlations between pre-existing or de novo autoimmune responses and poor transplant outcome.…
  • 2022 American Transplant Congress

    Long-Term Kidney Allotransplant Acceptance is Defined by a Shift from a T Cell to a B Cell Rich Immune Microenvironment Within the Graft

    E. S. Szuter1, T. Yokose1, M. T. Guinn1, J. Ge2, I. Rosales3, B. Kwon4, P. S. Russell1, A. Cuenca2, D. Kreisel5, P. Sage6, J. C. Madsen1, R. B. Colvin3, A. Alessandrini1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Boston Children's Hospital, Boston, MA, 3Department of Pathology, Massachusetts General Hospital, Boston, MA, 4Harvard College, Cambridge, MA, 5Department of Surgery, Washington University, St. Louis, MO, 6Transplantation Research Center, Renal Division, Brigham and Women’s Hospital, Boston, MA

    *Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations, such as DBA/2J to C57BL/6 (B6). Tolerant renal grafts develop aggregates of…
  • 2022 American Transplant Congress

    M1 Macrophage Polarization in Antibody-Mediated Rejection After Renal Transplantation and the Intervention Study of Iguratimod

    M. Zheng1, W. Zijie2, Z. Gui3, R. Tan1, M. Gu3

    1Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China, 2Jiangsu Province Hospital, Nanjing, China, 3Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China

    *Purpose: After kidney transplantation, Antibody Mediated Rejection (ABMR) is the main factor affecting the long-term survival of kidney transplantation. Previous studies have confirmed that macrophage…
  • 2022 American Transplant Congress

    Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance

    T. Hirai1, P. Lin2, T. L Ramos2, K. Garcia3, R. S Negrin2

    1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Blood and Marrow Transplantation, Stanford University, Stanford, CA, 3Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA

    *Purpose: Clinical trials for regulatory T cell (Treg) therapy in organ transplant has shown promising results. However, it is still under the debate which drugs…
  • 2022 American Transplant Congress

    CCR2 Antagonism Blocks Microbiota Pro-Inflammatory Effects on Lymph Node Architecture

    S. J. Gavzy1, R. Lakhan2, J. Iyyathurai2, V. Saxena2, Z. L. Lee2, B. Ma2, E. Mongodin2, J. S. Bromberg2

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Maryland, Baltimore, MD

    *Purpose: Fecal microbiota transfer (FMT) of Desulfovibrio desulfuricans (Desulfo) triggers a pro-inflammatory immune state, causing decreased laminin α4:α5 ratios in the lymph node (LN), increased…
  • 2022 American Transplant Congress

    Chronic Ethanol Exposure Prolongs Murine Allograft Survival

    D. Swift, M. Ford, W. Kitchens

    Department of Surgery, Emory University, Atlanta, GA

    *Purpose: Alcoholic liver disease is the leading indication for liver transplantation in the United States, and patients are increasingly transplanted without the traditional six month…
  • 2022 American Transplant Congress

    Infiltrating CD8+ Cytotoxic T Cells Are Converted to a Regulatory Phenotype in Accepted Kidney Allografts

    T. Yokose1, E. S. Szuter1, M. T. Guinn1, J. Ge2, I. Rosales3, M. Ford4, P. S. Russell1, A. G. Cuenca2, J. C. Madsen1, R. B. Colvin1, A. Alessandrini1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Boston Children's Hospital, Boston, MA, 3Department of Pathology, Massachusetts General Hospital, Boston, MA, 4Department of Surgery, Emory University, Atlanta, GA

    *Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations (i.e. DBA/2J to C57BL/6 (B6)) without any immunosuppressive drug treatment. We have…
  • 2022 American Transplant Congress

    Recipient Neutrophil Production of Myeloperoxidase is Required for NK Cell Activation During Acute Antibody Mediated Allograft Rejection

    Y. Mitsui1, D. Ueda1, S. Miyairi1, N. Dvorina1, K. S. Keslar1, A. Valujskikh1, B. William1, R. Fairchild2

    1Inflammation & Immunity, Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic Foundation, Cleveland, OH

    *Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and are required for rejection of…
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