Articles tagged "Mice"

2018 American Transplant Congress
A Novel Conditioning Approach to Establish Chimerism Using Manipulation of JAK-STAT Pathways
H. Xu, A. Merchak, L. Kahn, A. Chhabra, Y. Wen, Y. Huang, S. Ildstad.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.
Hematopoietic chimerism establishes donor-specific tolerance to solid organ allografts. Targeting recipient immune cells (T, NK cells and macrophages) can effectively reduce the dose of total…
2018 American Transplant Congress
Mitochondrial Quality Control through PGC-1α in Syngenic Mouse Heart Transplant
A. Cherry,¹ K. Porter,¹ H. Suliman,¹ J. Wang,² M. Mulvihill,² A. Kirk.²
¹Anesthesiology, Duke University, Durham, NC; ²Surgery, Duke University, Durham, NC.
Intro: Impaired mitochondrial function plays a role in graft dysfunction after transplant, and recovery is facilitated by mitochondrial quality control (MQC). Two key elements of…
2018 American Transplant Congress
T-bet and STAT6 Double Deficiency Favors IL-17 Immunity after Lung Transplantation
F. Liang,¹ R. Chen,¹ Q. Chen,² J. Ochando,³ Y. Ding,¹ J. Xu.¹
¹Department of Immunology, Capital Medical University, Beijing, China; ²Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Background: The long-term success of lung transplantation is mainly limited by the development of obliterative bronchiolitis (OB) in which IL-17 plays a critical role. Direct…
2018 American Transplant Congress
Prolongation of Skin Allograft Survival through Dietary Supplementation of Ayrl Hydrocarbon Receptor Ligands
A. Afrazi, L. Owens, J. Fechner, C. O'Driscoll, J. Mezrich.
Transplant Surgery, University of Wisconsin, Madison, WI.
The Aryl Hydrocarbon Receptor (AHR) is a cytosolic transcription factor with numerous endogenous and xenobiotic ligands playing a key role in a number of cellular…
2018 American Transplant Congress
Bone Marrow Derived Myeloid Suppressor Cell (BM-MDSCs) Prolongs the Graft Survival in Murine Heart Transplantation
K. Uchida, K. Fujimoto, K. Takeda, H. Bashuda, E. Yin, K. Okumura.
Atopy(Allergy) Research Center, Juntento University, Tokyo, Japan.
Purpose: To investigate the impact of BM-MDSCs on murine heart transplantationMaterial and Methods:Bone marrow cells were harvested and cultured with granulocyte-macrophage colony-stimulating factor (GM-CSF) and…
2018 American Transplant Congress
The Mark of Zorro: IL35-Coated Exosomes Cross-Dress and Exhaust Recipient T & B Cells during Transplant Tolerance
W. Burlingham,¹ J. Sullivan,¹ D. Lema,¹ Y. Tomita,² Y. Zhou,¹ D. Vignali.³
¹Surgery, University of Wisconsin, Madison, WI; ²Surgery, Tokyo Women's Hospital, Tokyo, Japan; ³Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA.
The folk-hero "Zorro" left his mark on by a sword-slashed "Z". In transplant recipients, rare Tregs also leave a mark on their conventional T &…
2018 American Transplant Congress
IL23R is a Pathogenic Gene in Type 1 Regulatory T Cells during Mouse Cardiac Transplantation Models
G. Gu, T. Lu, N. Xu, Q. Xia.
Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University School of Medicine, Shanghai, China.
IL23R has been confirmed to be a pathogenic gene in Th17 cells. However, its role in type 1 regulatory T cells (Tr1 cells) is not…
2018 American Transplant Congress
Histone Deacetylase Inhibition Mitigates Limb Ischemia Reperfusion Injury
S. Concors,¹ D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,⁴ W. Hancock,^3,4 M. Levine.^1,2
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Vascular composite allotransplantation (VCA) of the limb involves cold and warm ischemia, further limiting organ availability beyond the constraints of blood type, HLA compatibility,…
2018 American Transplant Congress
Tipping the “Immune Balance” towards Tolerance by Specific and Systematic Depletion of Donor and Host Effector Cells
R. Bascom, K. Tao, L. West.
Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada.
Purpose: To induce robust transplant tolerance in neonates with fully allogeneic spleen and bone marrow cells (SC/BMC) it is crucial to define the complex interplay…
2018 American Transplant Congress
Upregulated IL-33 in Heart Transplants Modulates Local Myeloid Populations to Protect against Chronic Allograft Rejection
Z. Zhang,¹ Q. Liu,¹ G. Hussey,² J. Dziki,² L. Mathews,¹ H. Dai,¹ G. Dwyer,^1,3 A. Lucas,¹ M. Oberbarnscheidt,¹ S. Badylak,² H. Turnquist.^1,3
¹University of Pittsburgh, Starzl Transplant Institute, Pittsburgh, PA; ²University of Pittsburgh, McGowan Institute for Regenerative Medicine, Pittsburgh, PA; ³Immunology, University of Pittsburgh, Pittsburgh, PA.
Purpose: Interleukin-33 (IL-33) is an “alarmin”, or a self-derived molecule that triggers pleotropic immune responses after release from damaged tissue. Yet, how IL-33 shapes alloresponses…