Articles tagged "Mice"

2018 American Transplant Congress
Specific Monocyte Memory to Allogeneic MHC Mediated by Paired Immunoglobulin Receptors (PIR)
H. Dai,¹ P. Lan,² A. Friday,¹ A. Williams,¹ M. Oberbarnscheidt,¹ X. Li,² F. Lakkis.¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA; ²Immunobiology, Houston Methodist Hospital, Houston, TX.
Monocytes distinguish between self and allogeneic non-self and contribute to allograft rejection by generating mature, IL-12+, DCs. The initial trigger of monocyte differentiation to DCs…
2018 American Transplant Congress
Improved Mouse Renal Transplantation Model Mimicking Clinical Antibody Mediated Rejection
D. Zhao,¹ T. Liao,¹ S. Li,¹ J. Zhou,² F. Han,¹ Y. Dong,³ Q. Sun.¹
¹Organ Transplantation Institution, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; ²Department of Pathology, Third Affiliated Hospital of Sun Yat-sen University, Guanghzou, Guangdong, China; ³Department of Pathology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Antibody mediated rejection (AMR) is main barrier to long term renal graft survival and mouse model is important to understand the mechanisms of AMR and…
2018 American Transplant Congress
Th17 and NK Responses Are Differentially Induced in Renal Allografts According to Recipient Murine Cytomegalovirus Dose and Strain
M. Shimamura,¹ M. Li,² S. Boddeda,¹ B. Chen,² Q. Zeng,¹ T. Schoeb,² V. Velazquez.¹
¹Center for Vaccines and Immunity and Dept. of Pediatric Infectious Diseases, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH; ²Depts. of Pediatric Infectious Diseases, Pathology, and Genetics, University of Alabama at Birmingham, Birmingham, AL.
Purpose: To study the impact of cytomegalovirus (CMV) recipient positive (R+) serostatus upon renal allograft injury, murine CMV (MCMV) D+/R+ kidney transplants using recipients infected…
2018 American Transplant Congress
Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection
J. Nie,¹ B. Ramaswami,² X. Guo,³ R. Hoffman,² G. Chalasani.³
¹Thoracic Surgery, Huazhong University of Science and Technology, Wuhan, Hubei, China; ²Surgery, Starzl Transplantation Institute, Pittsburgh, PA; ³Medicine, University of Pittsburgh, Pittsburgh, PA.
Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…
2018 American Transplant Congress
Primary Insult to the Native Lungs Are Needed for Antibodies to Lung Self-Antigens, Kα1Tubulin and Collagen V, to Be Pathogenic for the Development of Obliterate Airway Disease
M. Sharma, W. Liu, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hospital & Medical Center, Phoenix.
Introduction: Antibodies (Abs) to lung self-antigens (SAgs) have been correlated with development of bronchiolitis obliterans syndrome following human lung transplantation. Further, administration of Abs to…
2018 American Transplant Congress
Metabolic Therapy as a Platform for CTLA4Ig Costimulation Blockade in Preventing Allograft Rejection
C-.H. Cheng,^1,2 C-.F. Lee,^1,2 G. Furtmüller,³ B. Oh,³ C. Patel,¹ Y-.C. Lo,¹ M. Fryer,³ G. Brandacher,³ J. Powell.¹
¹Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD; ²Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, New Taipei City, Taiwan; ³Vascularized Composite Allotransplantation Laboratory, Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
The backbone of current immunosuppression regimens remains calcineurin inhibitors (CNI) in association with steroids, mycophenolate mofetil or mTOR inhibitors. However, their long-term administration is associated…
2018 American Transplant Congress
Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4⁺ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation
G. Dwyer,¹ L. Mathews,¹ A. Lucas,¹ B. Blazar,² H. Turnquist.¹
¹Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; ²Department of Pediatrics, University of Minnesota, Minneapolis, MN.
Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…
2018 American Transplant Congress
Modification of Macrophage Phenotype by the Magnetic Field
M. Kloc,¹ W. Chen,¹ J. Kubiak,^2,3 X. Li,¹ R. Ghobrial,¹ J. Wosik.⁴
¹Houston Methodist Research Institute, Houston, TX; ²WIHE, Warsaw, Poland; ³University of Rennes, Rennes, France; ⁴University of Houston, Houston.
Objective. Macrophages play a crucial role in health, disease and chronic rejection of transplanted organs. Chronic rejection of transplanted organs remains unresolved issue in organ…
2018 American Transplant Congress
Screening of RhoA/ROCK Inhibitors for the Ability to Prevent Chronic Rejection of Mouse Cardiac Allografts
W. Chen, W. Chen, X. Li, R. Ghobrial, M. Kloc.
THMRI, Houston, TX.
Objectives. Chronic rejection of transplanted organs is a major obstacle in human organ transplantation. Although the mechanisms of chronic rejection are poorly understood it is…
2018 American Transplant Congress
Neuropeptide PACAP Protects Hepatocyte against Liver Ischemia/Reperfusion Injury by Promoting Yes-Associated Protein (YAP) Function
Z. Xue, Y. Liu, C. Zhang, R. Busuttil, J. Kupiec-Weglinski, H. Ji.
Dept of Surgery, The DumontUCLA Transplant Center, Los Angeles, CA.
Background: Previously we have demonstrated that neuropeptide pituitary adenylate cyclase-activating polypeptides (PACAP) suppressed local inflammation, and protected liver against IRI by innervating the liver and…