Articles tagged "Mice"

2019 American Transplant Congress
Anti-CD272 Antibody (6B2) Induced Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allograft
E. Yin, M. Uchiyama, Y. Yamamoto, M. Niimi
Teikyo University, Tokyo, Japan
*Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
2019 American Transplant Congress
Differential Impact of Donor and Recipient Age on Post-Lung Transplantation Outcomes
K. Patel¹, C. Li¹, C. Wallace¹, J. Kilkenny¹, D. P. Allen¹, S. Nadig¹, M. Goddard², C. Krieg¹, C. Atkinson¹
¹Surgery, Medical University of South Carolina, Charleston, SC, ²Pathology, Royal Papworth Hospital NHS Trust, C, SC
*Purpose: Donor and recipient age at the time of lung transplantation (LTx) have been implicated in poor patient outcomes. The underlying mechanisms driving these effects…
2019 American Transplant Congress
Novel Role of Qa-1-Restricted Immunoregulation in Murine Cardiac Transplantation
J. Y. Choi¹, S. K. Eskandari¹, J. Assaker¹, I. Sulkaj¹, S. Cai¹, H. Allos¹, M. Uehara¹, M. Mohammad¹, B. S. Al Dulaijan¹, A. Bano¹, E. Al Huassain¹, H. I. Cantor², J. R. Azzi¹
¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Dana-Farbar Caner Institute, Boston, MA
*Purpose: HLA-E is an MHC class-1b molecule that is under-studied in the transplant setting. Recent clinical studies have revealed a robust association between allograft outcome…
2019 American Transplant Congress
Role of Innate Allorecognition Pathways in Mouse Renal Allograft Rejection
D. Zhao¹, H. Dai¹, K. Abou-Daya¹, A. Williams¹, M. Oberbarnscheidt¹, X. Li², F. Lakkis¹
¹Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, ²Houston Methodist Hospital Immunobiology & Transplant Science Center, Houston, TX
*Purpose: Allograft rejection is initiated by host immune system distinguishing between self and allogeneic non-self (allorecognition). Paired immunoglobulin-like receptor (PIR) and CD47 are molecules expressed…
2019 American Transplant Congress
Promoting Mitochondrial Fusion Alters the Interaction between Endothelial Cells and T Cells in Models of Transplantation
D. T. Tran, C. Atkinson, S. N. Nadig
Medical University of South Carolina, Charleston, SC
*Purpose: As semi-professional antigen-presenting cells, microvascular endothelial cells (mECs) play a central role in mediating allograft rejection. Cold storage and ischemia reperfusion injury increases mEC…
2019 American Transplant Congress
In Vivo Treg Expansion under Costimulation Blockade Targets Early Rejection and Improves Long-Term Outcome
C. Schwarz¹, B. Mahr², L. Unger¹, N. Pilat², H. Regele³, T. Wekerle²
¹Dept. of Surg. / Div. of Transplantation, Medical University Vienna, Vienna, Austria, ²Dept. of Surg. / Section of Transplantation Immunology, Medical University Vienna, Vienna, Austria, ³Clinical Institute of Pathology, Medical University Vienna, Vienna, Austria
*Purpose: Early rejection episodes are a major problem under CTLA4Ig/belatacept-based immunosuppression. We have previously shown that CTLA4Ig therapy is dependent on Tregs at low (LD)…
2018 American Transplant Congress
Histone Deacetylase Inhibition Mitigates Limb Ischemia Reperfusion Injury
S. Concors,¹ D. Aufhauser,¹ D. Murken,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,⁴ W. Hancock,^3,4 M. Levine.^1,2
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Vascular composite allotransplantation (VCA) of the limb involves cold and warm ischemia, further limiting organ availability beyond the constraints of blood type, HLA compatibility,…
2018 American Transplant Congress
Tipping the “Immune Balance” towards Tolerance by Specific and Systematic Depletion of Donor and Host Effector Cells
R. Bascom, K. Tao, L. West.
Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada.
Purpose: To induce robust transplant tolerance in neonates with fully allogeneic spleen and bone marrow cells (SC/BMC) it is crucial to define the complex interplay…
2018 American Transplant Congress
Upregulated IL-33 in Heart Transplants Modulates Local Myeloid Populations to Protect against Chronic Allograft Rejection
Z. Zhang,¹ Q. Liu,¹ G. Hussey,² J. Dziki,² L. Mathews,¹ H. Dai,¹ G. Dwyer,^1,3 A. Lucas,¹ M. Oberbarnscheidt,¹ S. Badylak,² H. Turnquist.^1,3
¹University of Pittsburgh, Starzl Transplant Institute, Pittsburgh, PA; ²University of Pittsburgh, McGowan Institute for Regenerative Medicine, Pittsburgh, PA; ³Immunology, University of Pittsburgh, Pittsburgh, PA.
Purpose: Interleukin-33 (IL-33) is an “alarmin”, or a self-derived molecule that triggers pleotropic immune responses after release from damaged tissue. Yet, how IL-33 shapes alloresponses…
2018 American Transplant Congress
α-1 Antitrypsin Facilitate Apoptosis Donor Cells Inducing Donor Specific Protection to Mice Cardiac Allografts
G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, C. Wang, J. Zhang, F. Ning, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Previous study has shown that intravenous infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) can induce tolerance of mice cardiac allografts with rapidly apoptosis of ECDI-SPs…