Articles tagged "Mice"

2019 American Transplant Congress
Kidney-Intrinsic Innate Immunity and Endoplasmic Reticulum Stress Pathways are Key Determinants of Severity of Ischemia-Reperfusion Injury Following Transplantation
L. Qiu¹, J. Wang¹, X. Yeap¹, C. Lin¹, Y. S. Kanwar², D. Fang², M. M. Abecassis¹, Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Ischemia-reperfusion injury (IRI) following kidney transplantation (KTx) frequently leads to delayed graft function and is detrimental to graft longevity. Causes and susceptibilities of KTx…
2019 American Transplant Congress
The Effects of Chronic Kidney Disease on Antiviral T Cell Response
R. L. Crepeau¹, H. Li², L. P. Daley-Bauer³, M. L. Ford¹, P. D. Winterberg²
¹Emory Transplant Center, Atlanta, GA, ²Pediatrics, Emory University School of Medicine, Atlanta, GA, ³Microbiology & Immunology, Emory University School of Medicine, Atlanta, GA
*Purpose: Accumulation of memory T cells bearing markers of sustained antigen stimulation have been described in patients with chronic kidney disease (CKD). Cytomegalovirus (CMV) establishes…
2019 American Transplant Congress
mTORC2 Restricts mTORC1 Metabolic Function in Dendritic Cells to Limit Their Allostimulatory Activity
H. Dai¹, A. Watson¹, A. Menk², D. Stolz³, G. Delgoffe², A. Thomson¹
¹Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, ²Tumor Microenvironment Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, ³Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA
*Purpose: Mechanistic target of rapamycin complex 2 (TORC2) deficiency in conventional dendritic cells (DC) results in their enhanced pro-inflammatory and T cell allostimulatory activity; however,…
2019 American Transplant Congress
Tubastatin-A, an HDAC6 Inhibitor, is Protective in Liver Ischemia Reperfusion Injury and Acetaminophen-Mediated Liver Injury
S. Concors¹, D. Murken¹, P. Hernandez¹, D. Aufhauser¹, Z. Wang¹, G. Ge¹, L. Krumeich¹, T. Bhatti², A. Kozikowski³, W. Hancock², M. H. Levine¹
¹Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA, ³Starwise Therapeutics, Madison, WI
*Purpose: Ischemia reperfusion injury (IRI) causes morbidity and contributes to early graft loss in liver transplantation and no current therapy exists. Liver injury complicates other…
2019 American Transplant Congress
Graft Perfusion with Alvespimycin, an HSP90 Inhibitor, Suppresses IL-2 and IL-12p40 Production in Graft-Infiltrating Cells, Leading to Prolongation of Graft Survival in Murine Heart Transplantation
T. Tanaka, T. Maehana, N. Masumori
Department of Urology, Sapporo Medical University, Sapporo, Japan
*Purpose: We have previously demonstrated that administration of a heat shock protein 90 (HSP90) inhibitor prolonged the allograft survival in murine skin and heart transplantations.…
2019 American Transplant Congress
Kupffer Cells Are Critical for Inflammation Resolution in Liver Ischemia Reperfusion Injury via TIM-4 Mediated Efferocytosis
M. Ni¹, H. Wang¹, D. Jin¹, J. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, X. Wang², Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Liver ischemia reperfusion injury (IRI) remains a clinical problem associated with both surgical and non-surgical settings. Innate immune-dominated inflammation drives the pathogenesis of liver…
2019 American Transplant Congress
Histone Deacetylase-2 Knockout in Renal Tubular Cells is Protective in Renal Ischemia-Reperfusion Injury
P. T. Hernandez¹, S. J. Concors¹, L. Krumeich¹, D. D. Aufhauser¹, Z. Wang¹, D. D. Murken¹, G. Ge¹, W. Hancock², M. Levine³
¹General Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, ²Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Transplant Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Ischemia-reperfusion injury (IRI) is a major source of morbidity in renal transplantation and is without targeted therapy. In renal transplantation, IRI contributes to poorer…
2019 American Transplant Congress
Fractalkine is Crucial in Ischemia Reperfusion Injury Related to Acute Rejection in an Allogeneic Heart Transplantation Model
T. Kanzawa¹, D. Tokita¹, T. Yamakawa¹, H. Ishigooka¹, H. Fukuda¹, H. Katsumata¹, S. Miyairi¹, R. Ishii¹, T. Hirai¹, K. Saiga¹, M. Okumi¹, T. Imai², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²KAN Research Institute, Kobe, Japan
*Purpose: Ischemia reperfusion injury (IRI) facilitates allograft rejection in renal transplantation recipients (IRI-related rejection). Controlling IRI improves graft survival. Fractalkine (FKN) is an inflammatory chemokine.…
2019 American Transplant Congress
TDCA/Valine Reverse Obesity and Ameliorate Alloimmune Responses through a Decreased Hypothalamic Expression of MCH
A. ElKhal¹, M. Markus Quante¹, T. Heinbokel¹, Y. Nian¹, K. Minami¹, R. Maenosono¹, J. Iske¹, B. Desai², A. Banks², E. Maratos-Flier², A. Elkhal¹, S. G. Tullius¹
¹Brigham and Women's Hospital, Boston, AL, ²Beth Israel Deaconess Medical Center, Boston, AL
*Purpose: Obesity is associated with low grade inflammation and bariatric surgery is the only effective treatment in reducing excess weight both pre- and post-transplant.*Methods: Here,…
2019 American Transplant Congress
Stabilization of Cell Junctions Ameliorates the Effects of Brain Death Induced Acute Lung Injury Post-Transplantation
D. P. Allen¹, Z. Tu¹, C. Wallace¹, C. Li¹, J. Kilkenny¹, K. J. Patel¹, D. Nord², S. N. Nadig¹, C. Atkinson²
¹Surgery, Medical University of South Carolina, CHARLESTON, SC, ²Microbiology & Immunology, Medical University of South Carolina, CHARLESTON, SC
*Purpose: Donor Brain death (BD) induces acute lung injury (BD-ALI), characterized by the breakdown of endo/epithelial barrier functions. These injuries are further exacerbated by ischemia…