2022 American Transplant Congress
Bioink Based on the DECM for 3D-Bioprinting of Bionic Pancreas – First Results of Animal
*Purpose: Tissue engineering is an interdisciplinary field involving activities based on two interrelated areas: developing new methods to repair, regenerate and replace damaged tissues and…2022 American Transplant Congress
P2X7R Inhibition Impairs In Vitro Training of Macrophages
*Purpose: Macrophage training and ATP-mediated P2X7R signaling are unrelated key elements of the innate immune response associated with allotransplant rejection. In the present study, we…2022 American Transplant Congress
Type 1 Natural Killer T-cells: Key Mediators of Ischemia- Reperfusion Injury in Hepatic Steatosis
*Purpose: Hepatic ischemia-reperfusion injury (IRI) poses a significant risk in liver transplantation and hepatic resection and is further exacerbated by hepatic steatosis. Type 1 Natural…2022 American Transplant Congress
Portal Hypertension Inhibits the Antitumor Effect of Liver-Resident NK Cells Through IL-33 Signal
Hiroshima University, Hiroshima, Japan
*Purpose: Portal vein hypertension (PHT) after living donor liver transplantation (LDLT) is known to have associated with poor prognosis. Among patients with hepatocellular carcinoma (N=…2022 American Transplant Congress
Non-Invasive Assessment of Hepatic Ischemia-Reperfusion Injury Using Dynamic Contrast Enhanced-MRI and T2 Mapping
*Purpose: Hepatic ischemia-reperfusion injury (IRI) is a consequence of liver transplantation and hepatectomy that varies in severity and clinical significance. The diagnosis is made based…2022 American Transplant Congress
Exosomal TGFbeta:LAP as Immunosuppressive Mediator of Allo-Tolerance
*Purpose: TGFβ has long been known as a key component in tolerance mediated by Treg cells. Here we show that, unlike IL10, but like CD39/CD73,…2022 American Transplant Congress
Autophagy is an Important Factor in the Development of Fibrosis Following Renal Injury; Implications for Post-Transplant IFTA
*Purpose: Interstitial Fibrosis and Tubular Atrophy (IFTA) is the most common cause of long-term graft failure following renal transplant. There is currently no effective therapy.…2022 American Transplant Congress
Protective Immunity Against a Murine Epstein-Barr Virus Homolog is Preserved During CD11b-CD154 Blockade
Emory University Transplant Center, Emory University, Atlanta, GA
*Purpose: CD154 pathway antagonism has shown to be a promising target for inducing long-time graft survival, in some cases showing efficacy that is superior to…2022 American Transplant Congress
Fibroblastic Reticular Cell Subset Transcriptional Reprogramming Differs in Response to Immunity versus Tolerance
1UMB, Baltimore, MD, 2Harvard University, Boston, MD
*Purpose: Lymph node (LN) fibroblastic reticular cells (FRCs) are central contributors to the LN niche. We hypothesized that FRC subsets reactive to immunity versus tolerance…2022 American Transplant Congress
Contributions of Allogenicity and Antigen Presentation to Regulatory B Cell Suppression
Center for Transplantation Sciences, Boston, MA
*Purpose: We previously generated in vitro Toll-like receptor (TLR)-activated B cells became regulatory B cells (Bregs) that suppress T cell proliferation and promote allograft tolerance.…
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