ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2022 American Transplant Congress

    Engineered IL-2 Plus Calcineurin Inhibitor Synergistically Expands Regulatory T Cells Transduced with Engineered IL-2 Receptor and Facilitates Establishment of Transplantation Tolerance

    T. Hirai1, P. Lin2, T. L Ramos2, K. Garcia3, R. S Negrin2

    1Urology, Tokyo Women's Medical University, Tokyo, Japan, 2Blood and Marrow Transplantation, Stanford University, Stanford, CA, 3Molecular and Cellular Physiology and Structural Biology, Stanford University, Stanford, CA

    *Purpose: Clinical trials for regulatory T cell (Treg) therapy in organ transplant has shown promising results. However, it is still under the debate which drugs…
  • 2022 American Transplant Congress

    CCR2 Antagonism Blocks Microbiota Pro-Inflammatory Effects on Lymph Node Architecture

    S. J. Gavzy1, R. Lakhan2, J. Iyyathurai2, V. Saxena2, Z. L. Lee2, B. Ma2, E. Mongodin2, J. S. Bromberg2

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Maryland, Baltimore, MD

    *Purpose: Fecal microbiota transfer (FMT) of Desulfovibrio desulfuricans (Desulfo) triggers a pro-inflammatory immune state, causing decreased laminin α4:α5 ratios in the lymph node (LN), increased…
  • 2022 American Transplant Congress

    Chronic Ethanol Exposure Prolongs Murine Allograft Survival

    D. Swift, M. Ford, W. Kitchens

    Department of Surgery, Emory University, Atlanta, GA

    *Purpose: Alcoholic liver disease is the leading indication for liver transplantation in the United States, and patients are increasingly transplanted without the traditional six month…
  • 2022 American Transplant Congress

    Infiltrating CD8+ Cytotoxic T Cells Are Converted to a Regulatory Phenotype in Accepted Kidney Allografts

    T. Yokose1, E. S. Szuter1, M. T. Guinn1, J. Ge2, I. Rosales3, M. Ford4, P. S. Russell1, A. G. Cuenca2, J. C. Madsen1, R. B. Colvin1, A. Alessandrini1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Boston Children's Hospital, Boston, MA, 3Department of Pathology, Massachusetts General Hospital, Boston, MA, 4Department of Surgery, Emory University, Atlanta, GA

    *Purpose: Mouse kidney allografts are spontaneously accepted in select, fully-mismatched donor-recipient strain combinations (i.e. DBA/2J to C57BL/6 (B6)) without any immunosuppressive drug treatment. We have…
  • 2022 American Transplant Congress

    Recipient Neutrophil Production of Myeloperoxidase is Required for NK Cell Activation During Acute Antibody Mediated Allograft Rejection

    Y. Mitsui1, D. Ueda1, S. Miyairi1, N. Dvorina1, K. S. Keslar1, A. Valujskikh1, B. William1, R. Fairchild2

    1Inflammation & Immunity, Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic Foundation, Cleveland, OH

    *Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and are required for rejection of…
  • 2022 American Transplant Congress

    Pro- and Anti-Tolerogenic Microbiota Induce Distinct Gut Microbiome Metabolic Pathways and Loco-Regional Immune Responses

    S. J. Gavzy1, R. Lakhan2, J. Iyyathurai2, V. Saxena2, Z. L. Lee2, B. Ma2, E. Mongodin2, J. S. Bromberg2

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Maryland, Baltimore, MD

    *Purpose: Colitis-associated Desulfovibrio desulfuricans (Desulfo) induces pro-inflammatory cytokine responses in dendritic cell and macrophage cell lines as well as primary cells. In contrast, Bifidobacterium pseudolongum…
  • 2022 American Transplant Congress

    Bioink Based on the DECM for 3D-Bioprinting of Bionic Pancreas – First Results of Animal

    M. Klak1, K. Kosowska1, T. Bryniarski1, I. Lojszczyk1, T. Dobrzanski2, G. Tymicki1, A. Filip1, A. A. Szczepankiewicz3, R. Olkowski4, A. Kosowska4, A. Berman1, A. Kaminski4, M. Wszola1

    1Foundation of Research and Science Development, Warsaw, Poland, 2Polbionica LTD, Warsaw, Poland, 3Institute of Experimental Biology M. Nencki PAN, Warsaw, Poland, 4Medical University of Warsaw, Warsaw, Poland

    *Purpose: Tissue engineering is an interdisciplinary field involving activities based on two interrelated areas: developing new methods to repair, regenerate and replace damaged tissues and…
  • 2022 American Transplant Congress

    P2X7R Inhibition Impairs In Vitro Training of Macrophages

    H. H. Lancia1, R. Sanchez2, A. G. Lellouch1, C. L. Cetrulo1, J. Ochando3, G. Benichou4

    1Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 4Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA

    *Purpose: Macrophage training and ATP-mediated P2X7R signaling are unrelated key elements of the innate immune response associated with allotransplant rejection. In the present study, we…
  • 2022 American Transplant Congress

    Type 1 Natural Killer T-cells: Key Mediators of Ischemia- Reperfusion Injury in Hepatic Steatosis

    J. R. Liggett1, J. Kang1, K. Loh1, K. Oza1, Y. Cui1, D. Kwon2, H. Li3, B. Kallakury2, T. Fishbein1, W. Cui1, K. Khalid1, A. H. Kroemer1

    1MedStar Georgetown Transplant Institute, Washington, DC, 2Pathology, MedStar Georgetown University Hospital, Washington, DC, 3Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) poses a significant risk in liver transplantation and hepatic resection and is further exacerbated by hepatic steatosis. Type 1 Natural…
  • 2022 American Transplant Congress

    Portal Hypertension Inhibits the Antitumor Effect of Liver-Resident NK Cells Through IL-33 Signal

    Y. Imaoka, M. Ohira, K. Sato, K. Imaoka, R. Nakano, Y. Tanaka, H. Ohdan

    Hiroshima University, Hiroshima, Japan

    *Purpose: Portal vein hypertension (PHT) after living donor liver transplantation (LDLT) is known to have associated with poor prognosis. Among patients with hepatocellular carcinoma (N=…
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