ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Mice"

  • 2022 American Transplant Congress

    Fibroblastic Reticular Cell Subset Transcriptional Reprogramming Differs in Response to Immunity versus Tolerance

    L. Li1, Y. Song1, M. Shirkey1, A. Kensiski1, W. Piao1, V. Saxena1, S. Gavzy1, B. Ma1, R. Abdi2, J. Bromberg1

    1UMB, Baltimore, MD, 2Harvard University, Boston, MD

    *Purpose: Lymph node (LN) fibroblastic reticular cells (FRCs) are central contributors to the LN niche. We hypothesized that FRC subsets reactive to immunity versus tolerance…
  • 2022 American Transplant Congress

    Contributions of Allogenicity and Antigen Presentation to Regulatory B Cell Suppression

    K. Lee, F. Qiang, K. Deng, R. Matheson, J. Lei, C. LeGuern, J. Markmann

    Center for Transplantation Sciences, Boston, MA

    *Purpose: We previously generated in vitro Toll-like receptor (TLR)-activated B cells became regulatory B cells (Bregs) that suppress T cell proliferation and promote allograft tolerance.…
  • 2022 American Transplant Congress

    Rhesus-Primatized Mouse Model Generated Using Transgenic Immunodeficient Mice

    C. Little1, W. J. Haynes1, L. Huang1, C. Daffada1, K. B. Wolfe2, E. Perrin2, J. A. Simpson1, J. A. Kropp Schmidt2, H. M. Hinkle2, L. T. Keding2, R. T. Behrens2, D. T. Evans2, D. Kaufman1, J. A. Thomson2, T. G. Golos2, M. Brown1

    1Surgery, University of Wisconsin, Madison, WI, 2University of Wisconsin, Madison, WI

    *Purpose: To develop a translational primatized mouse model, akin to humanized mice, that allows for high-throughput in vivo experimentation to augment non-human primate pre-clinical studies.*Methods:…
  • 2022 American Transplant Congress

    Immunomodulatory Effects of Probiotic Bifidobacterium Bifidum with Tacrolimus and Sirolimus in Mouse Skin Graft Model

    A. Han1, C. Chung2, H. Kim3, H. Ko4, E. Jo1, S. Min1, S. Kim5, H. Park5, J. Ha1

    1Seoul National University College of Medicine, Seoul, Korea, Republic of, 2Inha University Hospital, Incheon, Korea, Republic of, 3Korea University Guro Hospital, Seoul, Korea, Republic of, 4Kyung Hee University Hospital, Seoul, Korea, Republic of, 5Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea, Republic of

    *Purpose: Accumulating evidence suggests that gut microbiota actively crosstalks with the host immune system, and alterations of gut microbiota may exert immune regulatory effects. We…
  • 2022 American Transplant Congress

    Donor Kidney-Resident Passenger Macrophages Promote CCL8-CCR8 Mediated Early Allograft Inflammation

    A. Dangi1, I. Husain2, N. Natesh3, X. Shen3, J. Kwun4, X. Luo5

    1Medicine, Duke University Medical Center, Durham, NC, 2Duke University Medical Center, Durham, NC, 3Biomedical Engineering, Duke University, Durham, NC, 4Duke Transplant Center, Durham, NC, 5Duke University School of Medicine, Durham, NC

    *Purpose: Early intragraft infiltration of monocytes and macrophages has been associated with acute and chronic allograft rejections. Nevertheless, underlying mechanism remained poorly understood. In the…
  • 2022 American Transplant Congress

    A Novel Method for Ex Vivo Stimulation of Mesenchymal Stem Cells via Invariant Natural Killer T Cell Activation with ɑ-galactosylceramide

    R. Ishii1, E. Kawaguchi1, T. Yamakawa1, H. Ishigooka1, T. Ikeda1, R. Ishiyama1, K. Saiga1, T. Takagi1, Y. Ishii2, K. Tanabe1

    1Tokyo Women's Medical University, Tokyo, Japan, 2Department of Immunological Diagnosis, Juntendo University Graduate School of Medicine, Tokyo, Japan

    *Purpose: Mesenchymal stem cells (MSCs) typically exhibit unique regenerative and immunomodulatory properties when exposed to proinflammatory cytokines. Invariant natural killer T (iNKT) cells are known…
  • 2022 American Transplant Congress

    The Role of LAG3 in Antibody Responses to Kidney Transplantation

    M. Nicosia1, R. Fan1, J. Lee2, V. Gorbacheva1, A. M. Beavers1, N. Dvorina1, W. Baldwin III1, R. L. Fairchild1, B. Min3, A. Valujskikh1

    1Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 2Cardiovascular and Metabolic Science, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 3Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL

    *Purpose: The functions of coinhibitory receptor lymphocyte activation gene-3 (LAG3) in T cells are well studied, however its role in humoral immune responses remains poorly…
  • 2022 American Transplant Congress

    Absence of DAP12 Expression by Donor Liver-Derived Dendritic Cells Enhances Their Contact with T Cells in Host Secondary Lymphoid Tissue: Implications for Abrogation of MHC-mismatched Liver Transplant Tolerance in Mice

    R. Nakano, A. Perez Gutierrez, G. Camirand, D. A. Geller, A. W. Thomson

    University of Pittsburgh, Pittsburgh, PA

    *Purpose: Multiphoton intravital microscopy is a high-resolution, real-time, fluorescence imaging technique that enables study of interactions between cells in their native, 3-dimensional environment including organ…
  • 2022 American Transplant Congress

    Natural vs Induced ABO Antibodies in a Murine Model: Role of Sex and T Cells

    I. Adam1, B. Motyka1, K. Tao1, P. J. Cowan2, L. J. West1

    1University of Alberta, Edmonton, AB, Canada, 2University of Melbourne, Melbourne, Australia

    *Purpose: Interaction of ‘natural’ ABO antibodies (nAbs) with their cognate AB(H)-antigens (Ags) poses a high risk of rapid rejection of ABO-incompatible (ABOi) organ transplants. We…
  • 2022 American Transplant Congress

    Aquaporin 4 is a Mediator of Essential Dendritic Cell Functions

    M. Nicosia1, A. M. Beavers1, Y. Yamamoto1, T. Thompson2, T. Zindrick2, A. Valujskikh1

    1Inflammation and Immunity, Cleveland Clinic, Lerner Research Institute, Cleveland, OH, 2Aeromics, Cleveland, OH

    *Purpose: Aquaporins are a family of transmembrane water channels implicated in a broad range of physiological functions. We previously reported that Aquaporin 4 (AQP4) is…
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