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American Transplant Congress abstracts

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Articles tagged "Malignancy"

  • 2015 American Transplant Congress

    Pediatrics & Donor Derived Disease Transmission: The US OPTN Experience

    M. Green,1 S. Taranto,2 S. Covington,2 M. Michaels,1 C. Wolfe,3 D. Kaul.4

    1Pediatrics & Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2OPTN/UNOS, Richmond, VA; 3Medicine, Duke University School of Medicine, Durham, NC; 4Medicine, University of Michigan School of Medicine, Ann Arbor, MI.

    Potential donor derived disease transmission events (PDDTE) are tracked by the OPTN DTAC. Specific evaluation of potential transmissions from pediatric (ped) donors or the impact…
  • 2015 American Transplant Congress

    Kidney Transplantation After Hematopoietic Cell Transplantation in Plasma Cell Dyscrasias

    V. Domínguez-Pimentel,1 F. Fortich-Barrios,1 O. Siverio-Morales,1 E. Martín-Izquierdo,1 A. Jarque-López,1 N. Del Castillo-Rodríguez,1 J. García,1 P. Ríos,2 M. Macía.1

    1Division of Nephrology, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain; 2Division of Hematology, Hospital Nuestra Señora de la Candelaria, Santa Cruz de Tenerife, Spain.

    INTRODUCTION:The plasma cell dyscrasias (PCD) include a number of entities such as multiple myeloma (MM), primary amyloidosis (AL) and Monoclonal immunoglobulin deposition disease (MIDD). Hematopoietic…
  • 2015 American Transplant Congress

    Multicenter Study to Develop a Novel Prediction Index for Hepatocellular Carcinoma (HCC) Recurrence After Liver Transplant (LT)

    N. Mehta,1 J. Heimbach,2 D. Harnois,3 J. Dodge,1 J. Burns,3 D. Lee,3 W. Sanchez,2 J. Roberts,1 F. Yao.1

    1UCSF, San Francisco, CA; 2Mayo Clinic, Rochester, MN; 3Mayo Clinic, Jacksonville, FL.

    Several factors have been associated with a high risk of recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT), but no reliable risk score has…
  • 2015 American Transplant Congress

    Detecting Bowel Cancer in Pre-Dialysis, Dialysis Patients and Kidney Transplant Recipients – The DETECT Study

    G. Wong, J. Chapman, J. Craig.

    University of Sydney, Sydney, NSW, Australia.

    Background: Colorectal cancer (CRC) is the third most common solid organ cancer in people living with kidney disease, and has a very poor prognosis, with…
  • 2015 American Transplant Congress

    Donor-Derived Tumor Transmission Events. A Summary of 2008-2013 Data from the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC)

    M. Nalesnik,1 S. Taranto,2 S. Covington,2 E. Blumberg,1 M. Green,1 T. Gross,1 M. Klassen-Fischer,1 M. Pavlakis,1 C. Wolfe,1 D. Kaul.1

    1OPTN Disease Transmission Advisory Committee (DTAC), Richmond, VA; 2United Network for Organ Sharing, Richmond, VA.

    Purpose: Transmission of donor malignancy via transplantation is an uncommon but significant occurrence. The OPTN Disease Transmission Advisory Committee (DTAC) has monitored such complications since…
  • 2015 American Transplant Congress

    Deficiency of Naturally Occurring Anti-Angiogenic Antibodies Associate With the Development of Metastatic Cancer Post Renal Transplantation and Patient Death

    R. Carroll,1 A. Phillippe,2 R. Catar,2 H. Heidecke,2 D. Dragun.2

    1Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, Australia; 2Centre for Cardiovascular Research, Charite Hospital, Berlin, Germany.

    We assessed the presence of naturally occurring blocking antibodies to mediators of vascularisation and metastasis in Kidney Transplant Recipients (KTR) with metastatic cancer (n=11), non…
  • 2015 American Transplant Congress

    Everolimus-Based Immunosuppression Is Associated With a Reduced Risk of New-Onset Malignancies After Liver Transplantation

    P. De Simone,1 P. Carrai,1 L. Coletti,1 D. Ghinolfi,1 D. Campani,2 F. Filipponi.1

    1Hepatobiliary Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy; 2Pathology, University of Pisa Medical School Hospital, Pisa, Italy.

    Background and aim: The inhibitor of the mammalian target of rapamycin (mTOR) everolimus (EVR) has shown anti-proliferative effects in experimental and clinical models. We investigated…
  • 2015 American Transplant Congress

    Clinical Outcomes of Kidney Transplan Recipients After Sirolimus Or Everolimus Conversion. Experience in a Single Center

    L. Mesa, E. Manzi, M. Valderrama, J. Posada, J. Schweineberg, C. Duran, G. Echeverri, J. Villegas, O. Serrano, L. Caicedo.

    Transplant Unit, Fundación Valle del Lili, Cali, Colombia.

    Introduction. The use of m_TOR inhibitors sirolimus (SRL) and everolimus (EVL), in kidney transplant recipients (KTR) is an alternative immunosuppressive therapy to reduce or withdrawal…
  • 2015 American Transplant Congress

    Allo-Stimulated Interferon-γ Release and Natural Killer Cell Function Defines and Risk Stratifies Cancer Development in Kidney Transplant Recipients Who Have Cancer Post-transplantation

    C. Hope,1,2 A. Fuss,1,2 W. Hanf,1 P. Coates,1,2 P. Heeger,3 R. Carroll.1,2

    1The Centre for Clinical and Experimental Transplantation (CCET), Central Northern Adelaide Renal and Transplantation Services (CNARTS), Adelaide, South Australia, Australia; 2Medicine, The University of Adelaide, Adelaide, South Australia, Australia; 3Icahn School of Medicine, The Recanati-Miller Transplant Institute, New York City, NY.

    Reducing immunosuppression is efficacious in primary prevention of cancer in Kidney Transplant Recipients (KTR) but can precipitate graft rejection. Conventional immunosuppressive drug monitoring fails to…
  • 2015 American Transplant Congress

    Early Detection of HCC Mutations in Indeterminate Lesions Using Liquid Biopsies

    Y. Lin,1 K. Cavaness,2 Z. Zhang,1 S. Lin,3 K. Korenblat,1 G. Klintmalm,2 W. Chapman.1

    1Washington University, St. Louis, MO; 2Baylor University, Dallas, TX; 3Stanford University, Palo Alto, CA.

    Background Recent sequencing efforts have characterized the mutation profile of hepatocellular carcinoma (HCC); however, the relevance to clinical decision-making has been limited by the infrequency…
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