ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Malignancy"

  • 2018 American Transplant Congress

    Prognostic Value and Biological Significances of Five Long Non-Coding RNAs in Hepatocellular Carcinoma

    Y. Hou,1 Z. Yu,2 N. Tam,1 S. Huang,1 J. Yang,1 L. Wu,1 Y. Ma,1 X. He.1

    1Department of Organ Transplantation, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China; 2Laboratory of Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.

    Objectives Increasing evidence suggests that long non-coding RNA (lncRNA) plays a vital role in metastasis and development in hepatocellular carcinoma (HCC). Tumor progression severely affect…
  • 2018 American Transplant Congress

    Outcomes Analysis of Liver Transplantation Combined with Neoadjuvant Therapy in Patients with Unresectable Locally-Advanced Cholangiocarcinoma

    M. Wong,1 J. Kim,1 C. Eriksen,1 T. Pearson,1 J. Robbins,2 B. George,3 M. Zimmerman,1 J. Hong.1

    1Div. of Transplant Surgery, Medical College of Wisconsin and Froedtert Hospital (MCW & FH), Milwaukee, WI; 2Dept. of Radiation Oncology, MCW & FH, Milwaukee, WI; 3Div. of Hematology/Oncology, MCW & FH, Milwaukee, WI.

    Objective: Liver transplantation (LT) combined with neoadjuvant chemoradiation (NCR) in well-selected patients with unresectable cholangiocarcinoma (CCA) achieves excellent long-term recurrence-free survival. Current criteria for NCR-LT…
  • 2018 American Transplant Congress

    TP53 Mutations Lead to Increased Transcription of Circular RNAs in Exosomes Enhancing Tumor Invasiveness in Hepatocellular Carcinoma Bases on Bioinformatics Analysis

    Z. Yu, Y. Hou, R. Wang, X. Huang.

    The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.

    Objective Increasing evidence suggests that cicular RNAs play an important role in tumor. A recent study found the enrichment of cicular RNAs in HCC derived…
  • 2018 American Transplant Congress

    Impact of Elevated PSA, and Prostate Cancer in ESRD on Time to Transplant, and Survival

    N. Sarabu,1 N. Schiltz,2 D. Hricik.1

    1University Hospitals of Cleveland, Cleveland, OH; 2Case Western Reserve University, Cleveland, OH.

    Introduction: Despite concerns for over-diagnosis and over-treatment from prostate cancer screeening, transplant centers perform it. We studied effect of Elevated PSA, and Prostate cancer on…
  • 2018 American Transplant Congress

    Prediction of Hepatocellular Carcinoma Recurrence Following Liver Transplantation Using Combined Differential Gene Expression, Copy Number Variation and Somatic Mutation Analysis

    A. Humar,1 P. Liu,2 J. Luo,3 M. Nalesnik,3 A. Singhi,3 G. Tseng,2 G. Michalopoulos.3

    1Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA; 2Biostatistics, University of Pittsburgh, Pittsburgh, PA; 3Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.

    Liver allocation for transplant candidates with hepatocellular carcinoma is limited by OPTN policy to patients whose tumors remain within size limits defined by Milan criteria.…
  • 2018 American Transplant Congress

    Long-Term Follow-Up of Patients with Primary Sclerosing Cholangitis Undergoing Liver Transplantation with Duct-to-Duct Biliary Reconstruction

    L. Coromina Hernandez, B. Eghtesad, T. Diago, K. Hashimoto, M. Fujiki, C. Quintini, F. Aucejo, G. Iuppa, A. Hassan, N. Menon, C. Miller.

    Transplant Surgery, Cleveland Clinic, Cleveland, OH.

    Background:Reconstruction of biliary drainage after liver transplantation (LTx) in patients with primary sclerosing cholangitis (PSC) has been a matter of controversy. Over the recent years,…
  • 2018 American Transplant Congress

    Liver Transplantation for Locally Advanced Intrahepatic Cholangiocarcinoma Treated with Neoadjuvant Therapy: A Pilot Cohort Study

    K. Lunsford,1 M. Javle,2 K. Heyne,1 R. Shroff,2 R. Hassan Ali,2 C. Mobley,1 D. Victor,1 A. Kaseb,2 T. Aloia,2 C. Conrad,2 X. Li,1 H. Monsour,1 A. Gaber,1 J-.N. Vauthey,2 R. Ghobrial.1

    1Houston Methodist Hospital, Houston, TX; 2MD Anderson Cancer Center, Houston, TX.

    INTRODUCTIONIntrahepatic cholangiocarcinoma (iCCA) is a well-recognized contraindication for liver transplantation (LT). Recent reports indicate favorable LT outcomes for early iCCA (<2cm), but, poor survival persists…
  • 2018 American Transplant Congress

    Impact of Antecedent Malignancy on Kidney Transplant Outcomes: Patient, Graft, and Cancer-Free Survival

    O. Serrano,1 S. Mongin,2 D. Berglund,1 D. Vock,3 S. Chinnakotla,1 T. Dunn,1 E. Finger,1 R. Kandaswamy,1 T. Pruett,1 A. Matas.1

    1Surgery, University of Minnesota, Minneapolis, MN; 2Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, Minneapolis, MN; 3Biostatistics, University of Minnesota, Minneapolis, MN.

    OBJECTIVE: Non-skin pretransplant malignancy (NSPTM) has historically been considered a relative contraindication to kidney transplantation (KT). In addition to the conventional risk factors for cancer,…
  • 2018 American Transplant Congress

    Risk Factors of De Novo Malignancies after Liver Transplantation

    M. Altieri,1 O. Seree,2 J. Dumortier,3 GREF2 Groupe de Recherche Français en Greffe de Foie.

    1Service d'HepatoGastroenterologie, Nutrition et Oncologie Digestive, CHU de Caen, Caen, France; 2Réseau Régional de Cancérologie Onco-Basse-Normandie, Herouville Saint-Clair, France; 3Service d'HepatoGastroenterologie, Hospices Civils de Lyon, Hôpital de la Croix Rousse, Lyon, France.

    De novo malignancies after liver transplantation (LT) are one of the leading causes of late mortality, with a reported risk of malignancies twice as high…
  • 2017 American Transplant Congress

    De Novo Malignancy Occurrence After Kidney Transplantation in HLA-Sensitized Patients Treated with B-Cell Targeting Therapy.

    L. Couzi,1,2,3 P. Davis,1 J. Visentin,1,2,3 B. Taton,1 G. Guidicelli,1 H. Kaminski,1,2,3 P. Merville,1,2,3 T. Bachelet.4

    1CHU de Bordeaux, Bordeaux, France; 2Université de Bordeaux, Bordeaux, France; 3UMR CNRS 5164 Immunoconcept, Bordeaux, France; 4Clinique Saint-Augustin-CTMR, Bordeaux, France

    Management of high risk transplantations in patients with preformed DSA still remains a dilemma. Many groups propose to increase the immunosuppression in these patients by…
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