ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Major histocompatibility complex (MHC)"

  • 2022 American Transplant Congress

    Immune Checkpoints, Immune Cells, and MHC Expression in the Tumor Microenvironment of Resected Hepatocellular Carcinomas

    A. Baquerizo1, V. Vavinskaya2, S. Bagsic1, A. Rojas3, A. Mhoyan4, C. Frenette1, L. Sher5, M. Romero3, J. Fisher1, C. Marsch1, R. Schaffer1

    1Scripps, La Jolla, CA, 2UCSD, San Diego, CA, 3University, Seville, Spain, 4Kaiser, San Diego, CA, 5USC, Los Angeles, CA

    *Purpose: Advances in tumor biology has shown the important role of the tumor microenvironment (TME) in tumor growth and metastasis. A better understanding of the…
  • 2022 American Transplant Congress

    Specificity and Avidity of Donor MHC-Specific B Cells in Naive, Rejecting and Tolerant Mice

    I. Sayin1, S. Khiew2, D. Yin1, P. Sage3, C. B. Cavazzoni3, R. King4, A. Chong1

    1Department of Surgery, University of Chicago, Chicago, IL, 2Merck, Boston, MA, 3Brigham and Women's Hospital, Boston, MA, 4Department of Microbiology, University of Alabama, Birmingham, AL

    *Purpose: Antibody-mediated rejection is recognized as an important mediator of graft loss in the clinic, and the induction of donor-specific B cell tolerance may contribute…
  • 2021 American Transplant Congress

    Human Leukocyte Antigen Mismatches Between Donor-Recipient or Donor-Donor are Not Associated with Adverse Pancreas Outcomes in Pancreas After Kidney Transplant Recipients

    S. Parajuli, D. Kaufman, B. Welch, H. Sollinger, D. Mandelbrot, J. Odorico

    University of Wisconsin, MADISON, WI

    *Purpose: A greater degree of HLA mismatch has been previously associated with inferior graft survival in kidney and pancreas transplantation. Pancreas after kidney (PAK) recipients…
  • 2021 American Transplant Congress

    Transplant Glomerulopathy in the Absence of Donor-specific HLA Antibodies: Risk Factors, Histopathological Features and Graft Outcome

    A. Senev, E. Van Loon, M. Emonds, M. Naesens

    Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium

    *Purpose: Transplant glomerulopathy (TG) is established as a hallmark of chronic antibody-mediated rejection in kidney transplant patients with donor-specific HLA antibodies (HLA-DSA). The clinical importance…
  • 2020 American Transplant Congress

    Calculated Panel Reactive Antibody Values Increase for Kidney Transplant Candidates with HLA-DQA and HLA-DPB Unacceptable Antigens

    E. P. Kransdorf1, C. Murphey2, M. Maiers3, L. Gragert4

    1Cedars-Sinai Heart Institute, Beverly Hills, CA, 2Immunogenetics Lab, Southwest Immunodiagnostics, Inc., San Antonio, TX, 3Bioinformatics Research, Be The Match/National Marrow Donor Program, Minneapolis, MN, 4Department of Pathology, Tulane University School of Medicine, New Orleans, LA

    *Purpose: Calculated panel-reactive antibody (CPRA) is the official metric of sensitization used by the United Network for Organ Sharing (UNOS) for kidney allocation. CPRA includes…
  • 2020 American Transplant Congress

    Novel Role of Qa-1, a Murine Homolog of HLA-E, in Controlling Follicular Helper T Cells During Humoral Alloimmunity

    J. Y. Choi1, S. K. Eskandari1, S. Cai1, J. Assaker1, I. Sulkaj1, H. Allos1, J. Alhaddad1, P. Chu1, H. Kim2, H. I. Cantor2, J. R. Azzi1

    1Medicine, Brigham and Women's Hospital, Boston, MA, 2Immunology, Dana Farber Cancer Institute, Boston, MA

    *Purpose: Antibody-mediated rejection (AMR) is a major challenge in prolonging allograft survival. Limited insight into the humoral alloimmunity hinders the development of therapeutic strategies. We…
  • 2020 American Transplant Congress

    Extended HLA Typing of Kidney Transplant Pairs is Necessary to Assign Presence of Donor-Specific Anti-HLA Antibodies

    A. Senev1, V. Van Sandt2, M. Naesens1, M. Emonds1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2HILA, Rode Kruis Vlaanderen, Leuven, Belgium

    *Purpose: The need for extended high-resolution (HR) HLA genotyping in solid organ transplantation is currently widely debated due to higher costs and questioned clinical importance.…
  • 2020 American Transplant Congress

    The Eplet-Mismatch Landscape in Kidney Patients and Deceased Donors in British Columbia

    J. Tran1, O. Gunther2, J. Lan1, M. Kadatz1, R. Sapir-Pichhadze3, P. A. Keown1

    1University of British Columbia, Vancouver, BC, Canada, 2Gunther Analytics, Vancouver, BC, Canada, 3McGill University, Montreal, QC, Canada

    *Purpose: Minimizing quantitative donor/recipient mismatch at the HLA epitope level may optimize graft outcomes in renal transplantation, but the degree to which optimal matching can…
  • 2019 American Transplant Congress

    Dendritic Cells Transduced with Autoimmune Regulator Exhibit Immature Properties and Prolong Heart Allograft Survival

    Y. Zhang, Z. Zhu, M. Chen, S. Huang, C. Sun, W. Ju, Z. Guo, X. He

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    *Purpose: The expression of the Aire (Autoimmune regulator) gene was observed to inhibit the maturation and activation of dendritic cells (DCs) and induce transplantation tolerance.*Methods:…
  • 2019 American Transplant Congress

    Prolongation of Allograft Survival via Donor MHC Chimerism Induced by Exosomes

    B. Gonzalez Nolasco1, M. Wang1, W. Orent1, A. Prunevieille1, J. O1, K. Ahrens1, J. C. Madsen2, G. Benichou1

    1Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Surgery, Center for Transplantation Sciences, Division of Cardiac Surgery, Massachusetts General Hospital, Boston, MA

    *Purpose: Achieving robust and durable host immune tolerance of allogeneic transplants is the ultimate goal in clinical transplantation. Mixed chimerism induced via donor bone marrow…
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