Articles tagged "Machine preservation"

2021 American Transplant Congress
Characterization of Kidney Small Extracellular Vesicles Released During Normothermic Machine Perfusion
W. W. Woud¹, A. Arykbaeva², D. de Vries², I. Alwayn², K. Boer¹, C. Baan¹, M. Hoogduijn¹, R. Minnee³
¹Internal Medicine, Nephorology and Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Department of Surgery, LUMC, Leiden, Netherlands, ³Department of Surgery, Division of Hepato-Pancreato-Biliary and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands
*Purpose: By characterizing and quantifying the dynamical release of kidney Extracellular Vesicles (EVs) during Normothermic Machine Perfusion (NMP), we aim to gain a better understanding…
2021 American Transplant Congress
Normothermic-Hyperthermic Machine Perfusion Could Increase Response to Pharmacological Intervention in Mitigation of Liver Steatosis
F. Zhou, M. Xu, G. A. Upadhya, Y. Lin, W. C. Chapman
Surgery, Washington University in St. Louis, St. Louis, MO
*Purpose: To study the feasibility of mitigating rat liver steatosis with ex-situ normothermic-hyperthermic machine perfusion using a multi-drug ‘defatting’ combination.*Methods: 16 male Zucker obese rats…
2020 American Transplant Congress
Hypothermic Machine Perfusion Can Improve Hypoxia Tolerance in Human Discarded Liver
T. Ito, K. Kadono, H. Kojima, S. Kageyama, H. HIrao, K. Nakamura, K. J. Dery, A. E. Murray, J. Aziz, R. W. Busuttil, J. Kupiec-Weglinski, F. M. Kaldas
The Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: The wider use of livers from expanded criteria donors may help improve access to liver transplantation (LT). Normothermic machine perfusion in LT has been…
2020 American Transplant Congress
Bridging the Gap: Normothermic Perfusion of Discarded Livers Significantly Alleviates the Donor Shortage
S. Raigani, R. J. De Vries, C. Carroll, Y. Chen, D. C. Chang, K. Uygun, H. Yeh
Transplant Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: European studies have shown that discarded liver grafts can be successfully transplanted if they meet viability criteria during normothermic machine perfusion (NMP). The potential…
2020 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion is Superior to Anoxic and Oxygenated Hypothermic Machine Perfusion for the Preservation of DCD Porcine Kidney Grafts
L. Mazilescu¹, M. Kaths², P. Urbanellis¹, M. Hamar³, T. Goto¹, I. Linares-Cervantes¹, Y. Noguchi¹, A. Konvalinka¹, A. Ghanekar¹, D. Bagli⁴, R. John⁵, L. Robinson⁶, M. Selzner¹
¹Multi Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada, ²Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany, ³Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ⁴Departments of Surgery(Urology)&Physiology, The Hospital for Sick Children, Toronto, ON, Canada, ⁵Laboratory Medicine & Pathobiology, Toronto General Hospital, Toronto, ON, Canada, ⁶Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: To increase the donor pool, better preservation strategies for the storage of marginal kidney grafts are crucial. Currently, kidney grafts are either stored on…
2020 American Transplant Congress
Accomplishment of Ischemia-Free Kidney Transplantation Using Normothermic Machine Perfusion
G. Chen, X. He, C. Wang, X. Yuan, M. Han, Z. Guo
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
*Purpose: Ischemia-reperfusion injury (IRI) has been considered an inevitable event in organ transplantation since the first successful kidney transplant was performed in 1954. To avoid…
2020 American Transplant Congress
The Changes of Transaminases, Lactate Dehydrogenase and pH Levels During Normothermic Liver Preservation Correlate with Early Allograft Dysfunction
C. Bogensperger
Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria
*Purpose: Normothermic liver preservation (NMP) has become a clinically established tool to preserve livers in a near-physiological environment. Currently, decreasing lactate and physiological pH-levels are…
2020 American Transplant Congress
Development of a Split Liver Machine Perfusion Protocol to Provide Comparative Controls in Assessing Therapeutic Interventions
J. A. Attard¹, L. Wallace¹, Y. Boteon¹, V. Ronca¹, D. Osei-Bordom¹, Y. Oo¹, H. Mergental², D. Mirza², S. Afford¹
¹Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United Kingdom, ²Liver Surgery Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom
*Purpose: Ex situ donor liver machine perfusion is developing into a promising tool to test organ viability prior to transplantation and vehicle to assess novel…
2020 American Transplant Congress
Comparison of Specificity and Sensitivity of Clinical Viability Criteria to Assess Transplantability of High-Risk Donor Livers
H. Mergental¹, J. Hodson², R. W. Laing¹, Y. L. Boteon¹, J. Attard¹, L. Wallis³, A. Schlegel¹, P. Muiesan¹, M. Abradelo¹, M. P. Perera¹, D. Mirza⁴, S. C. Afford³
¹Liver Unit, Queen Elizabeth Hospital, Birmingham, United Kingdom, ²Department of Statistics, Queen Elizabeth Hospital, Birmingham, United Kingdom, ³Centre for Liver and Gastroenterology Research, University of Birmingham, Birmingham, United Kingdom, ⁴Liver Unit, Darius Mirza, Birmingham, United Kingdom
*Purpose: Normothermic machine perfusion (NMP) of the liver allows objective assessment before transplantation. To date, Birmingham (BC), Cambridge (CC) and Groningen Criteria (GC; Table 1A)…
2020 American Transplant Congress
Genome-Wide Transcriptome Analysis of Extreme Marginal Renal Grafts Indicates Earlier Repair and Less Damage Following Normothermic Ex-Vivo Kidney Perfusion Preservation
P. Urbanellis¹, L. Mazilescu¹, C. McEvoy¹, S. Ganesh¹, R. John¹, I. Mucsi¹, A. Ghanekar¹, D. Bagli², A. Konvalinka¹, L. Robinson¹, M. Selzner¹
¹University Health Network, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) was shown to prevent delayed graft function of kidneys subjected to prolonged warm ischemia (WI) compared to static cold…

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