Articles tagged "Machine preservation"

2021 American Transplant Congress
Early Experience with Machine Retrograde Perfusion of Deceased Donor Kidneys: Short-term Outcomes of a Prospective Study
J. Zeng, Q. Zhong, S. Yin, Z. Jia, Z. Huang, Y. Fan, X. Wang, T. Lin, T. Song
Urology Institute and Organ Transplantation Center, West China Hospital, Chengdu, China
*Purpose: To maximize the utilization of potential kidneys, improving perfusion and preservation technique is necessary. This article mainly investigated the safety and efficacy of retrograde…
2021 American Transplant Congress
Dual Lactate Clearance in the Liver Viability Assessment During Normothermic Machine Perfusion
M. Xu¹, F. Zhou¹, O. Ahmed¹, J. Shin¹, Y. Zhu¹, G. Upadhya¹, K. Byrnes², B. Wong¹, J. Kim¹, Y. Lin¹, W. Chapman¹
¹Department of Surgery, Washington University, St. Louis, MO, ²Department of Pathology and Immunology, Washington University, St. Louis, MO
*Purpose: Liver normothermic machine perfusion (NMP) has been increasingly performed as a tool of organ preservation and to evaluate donor function. The perfusate lactate clearance…
2020 American Transplant Congress
Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage: Preliminary Clinical Experience from a Prospective, Multi-Center Randomized Controlled Trial
G. G. Panayotova¹, R. Quillin III², F. Paterno¹, K. Lunsford¹, M. A. McCarty¹, A. Bailey², G. Dikdan¹, J. Rosado¹, S. Shah², J. V. Guarrera¹
¹Transplant and HPB Surgery, Rutgers NJMS, Newark, NJ, ²Division of Transplantation, University of Cincinnati, Cincinnati, OH
*Purpose: Hypothermic oxygenated machine perfusion (HMP-O2) is a novel liver preservation technique currently in clinical trials. It has the potential to mitigate ischemia/reperfusion injury, as…
2020 American Transplant Congress
Normothermic Machine Perfusion of Rat Liver: Comparing Two Perfusion Methods
F. Zhou, M. Xu, O. Ahmed, G. A. Upadhya, Y. Lin, W. C. Chapman
Surgery, Washington University in St. Louis, St. Louis, MO
*Purpose: Isolated perfused rodent liver (IPRL) model has gained popularity in ex-vivo rat liver preservation and pharmacological intervention studies. Experimental conditions and system layouts vary…
2020 American Transplant Congress
Normothermic Machine Perfusion of Extended Criteria Donor Livers: Identification of Protein Biomarkers Predictive of Graft Viability and Post-Transplant Complications
L. L. Wallace¹, J. Attard¹, Y. Boteon¹, R. Laing¹, J. Yu², T. Perera³, D. Mirza³, H. Mergental³, S. Afford¹
¹Centre for Liver and Gastrointestinal Research, University of Birmingham and the NIHR Biomedical Research Centre, UHB NHS Foundation Trust, Birmingham, United Kingdom, ²School of Biosciences, Advanced Mass Spectrometry Facility, University of Birmingham, Birmingham, United Kingdom, ³Liver Unit, The Queen Elizabeth Hospital, Birmingham, United Kingdom
*Purpose: The Viability Testing and Transplantation of mArginal donor Livers Clinical Trial (VITTAL) demonstrated the capacity of Normothermic Machine Perfusion (NMP) to increase the proportion…
2020 American Transplant Congress
Development of a Novel Multidrug Combination to Defat Steatotic Rat Liver via Normothermic Machine Perfusion
M. Xu¹, F. Zhou¹, O. Ahmed¹, G. Upadhya¹, J. Jia¹, C. Lee¹, J. Xing¹, L. Ye¹, S. Shim¹, Z. Zhang¹, K. Byrnes², B. Wong¹, J. Kim¹, Y. Lin¹, W. Chapman¹
¹Surgery, Washington University, St. Louis, MO, ²Pathology and Immunology, Washington University, St. Louis, MO
*Purpose: Hepatic steatosis is now the leading cause of liver discards in deceased donors. Previous studies (Yarmush et al., Y defatting) have successfully reduced the…
2020 American Transplant Congress
Immunomodulation During Normothermic Ex Vivo Machine Perfusion of the Rat Liver
K. Carlson¹, F. Najmabadi¹, J. Pavan-Guimaraes¹, W. J. Burlingham¹, C. M. Capitini², D. P. Al-Adra¹
¹Surgery, University of Wisconsin, Madison, WI, ²Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: Transplantation is the best treatment option for end-stage liver failure. There remains a critical need to develop targeted therapeutic strategies to decrease graft rejection…
2020 American Transplant Congress
What Happens When You Administer Mesenchymal Stromal Cells During Normothermic Machine Perfusion of Porcine Kidneys: Possible and Helpful or Not?
K. Rozenberg¹, L. Knijff¹, J. Sierra-Parraga², L. Lo Faro¹, M. Hoogduijn², C. Baan², J. Hunter¹, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands
*Purpose: Donation after circulatory death kidneys are widely used to increase the donor pool, despite their inferior quality. Normothermic machine perfusion (NMP) could provide a…
2020 American Transplant Congress
Real-Time Viability Assessment During Normothermic Machine Perfusion with Resonance Raman Spectroscopy
R. J. De Vries¹, S. Raigani¹, P. Romfh², S. E. Cronin¹, C. A. Pendexter¹, C. Carroll¹, T. M. Van Gulik³, P. Chen², K. Uygun¹, H. Yeh¹, S. N. Tessier¹
¹Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Pendar Technologies, Cambridge, MA, ³Surgery, Amsterdam University Medidical Centers, Location AMC, Amsterdam, Netherlands
*Purpose: Viability assessment during normothermic machine perfusion (NMP) continues to lack objective metrics that facilitate accurate clinical decision making, in order to minimize discard rates…
2020 American Transplant Congress
A Technique for Ex-Vivo Perfusion of Donor Kidneys for Transplantation in the Mouse
R. Plenter¹, S. Jain², J. J. Pomposelli¹, T. Nydam¹, A. Jani²
¹Pulmonary Division, University of Colorado, Aurora, CO, ²Renal Division, University of Colorado, Aurora, CO
*Purpose: Ex-vivo perfusion of donor kidneys is widely employed in the US and significantly reduces DGF. Development of a pre-clinical perfusion technique may provide an…

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