Articles tagged "Machine preservation"

2021 American Transplant Congress
Feasibility of Normothermic Ex Vivo Kidney Perfusion for Human Kidney Transplantation: First North American Results
L. I. Mazilescu¹, P. Urbanellis¹, J. S. Kim¹, A. Konvalinka¹, T. W. Reichman¹, L. A. Robinson², A. Ghanekar¹, M. Selzner¹
¹Ajmera Transplant Program, Toronto General Hospital, Toronto, ON, Canada, ²Department of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex vivo kidney perfusion is a novel preservation technique with promising results in porcine models and initial clinical results in one European center.…
2021 American Transplant Congress
Versatile Strategy to Enhance Nanomedicine Delivery to Graft Endothelial Cells
C. Albert¹, L. G. Bracaglia¹, A. Koide², J. DiRito¹, T. Lysyy¹, C. Edwards¹, J. T. Langford¹, D. Haakinson¹, S. A. Hosgood³, M. L. Nicholson³, J. S. Pober¹, W. M. Saltzman¹, S. Kiode², G. Tietjen¹
¹Yale University, new haven, CT, ²Perlmutter Cancer Center, New York University, Langone Medical Center, New York, NY, ³University of Cambridge, Cambridge, United Kingdom
*Purpose: Efficient delivery of therapeutics to graft endothelial cells (EC) can potentially render organs more resistant to injury, improving clinical outcomes. Specific targeting of polymeric…
2020 American Transplant Congress
Salvaging Discarded Livers with Normothermic Machine Perfusion: Is it Worth the Cost?
R. J. de Vries, S. Raigani, C. Carroll, Y. Chen, D. C. Chang, J. F. Markmann, K. Uygun, H. Yeh
Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Normothermic machine perfusion (NMP) enables transplantation of discarded grafts with excellent outcomes in clinical trials. The cost of deploying NMP is often cited as…
2020 American Transplant Congress
Tetramethylpyrazine Activated Pparγ in Resuscitating the Liver Graft Donatedafter Cardiac Death
F. Zhen, F. Lin, Z. Lihua, L. Wenjin, X. Yan, C. Yong, Y. Qifa
Zhongnan Hospital of Wuhan University, Wuhan, China
*Purpose: to identify whether Tetramethylpyrazine (TMP) pretreatment can protect DCD grafts preserved during cold storage or/and HMP and transplanted.The protective mechanisms of TMP were also…
2020 American Transplant Congress
Proteomics and Metabolomics Technologies Reveal the Effect of Oxygen in Hypothermic Machine Perfusion to Alleviate Donation after Circulatory Death Liver Injury
X. Zeng¹, X. Fan², Y. Wang², Q. Xia¹, J. Liu¹, H. Li¹, Q. Ye², Z. Wang¹
¹Department of Urology, Union Hospital, Affiliated TongJi Medical College, Huazhong University of Science & Technology, Wuhan, China, ²Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan, China
*Purpose: To compare the effects of oxygenated and nitrogenated hypothermic machine perfusion on the preservation of donation after circulatory death (DCD) livers, and to explore…
2020 American Transplant Congress
Rouleaux Formation in Human Livers During Normothermic Machine Perfusion
M. Harris¹, S. Raigani², C. Albert³, M. Reschke³, C. Carroll², J. T. Langford¹, C. Edwards⁴, D. Mulligan⁴, D. Haakinson¹, K. Uygun², H. Yeh², G. Tietjen¹
¹Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, ²Division of Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Yale School of Engineering and Applied Science, New Haven, CT, ⁴Surgery, Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT
*Purpose: We recently discovered that red blood cells form rouleaux plugs in human kidney vasculature during normothermic machine perfusion (NMP) and are associated with poor…
2020 American Transplant Congress
Delayed Kidney Transplant (KT) up to 2 Days in Combined Liver-Kidney Transplantation (CLKT) Offers Similar Renal Function as KT Alone: Comparison Analysis with Mate Kidneys
B. Ekser¹, E. Taber-Hight², P. Mihaylov¹, C. A. Kubal¹, R. S. Mangus¹, J. A. Fridell¹, A. J. Lutz¹, O. Adebiyi³, T. E. Taber³, A. Sharfuddin³, M. S. Yaqub³, D. P. Mishler³, M. D. Anderson³, J. A. Powelson¹, W. C. Goggins¹
¹Division of Transplant Surgery - Indiana University, Indianapolis, IN, ²Division of Nephrology, Indiana University, Indianapolis, IN, ³Division of Nephrology - Indiana University, Indianapolis, IN
*Purpose: Delayed KT in CLKT (Indiana Approach) offers a less hostile environment with hemodynamically more stable patient at the time of KT. Positive impact of…
2020 American Transplant Congress
The Application of Hypothermic Machine Perfusion in Kidney Transplantation from Delay Graft Function High Risk Donor
Y. Li, X. Hu, G. Chen, C. Ding, W. Xue
Kidney Transplantation Department, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
*Purpose: To investigate the clinical effect of the hypothermic machine perfusion (HMP) method on renal transplantation from high risk donation after citizen death (DCD) and…
2020 American Transplant Congress
Donor Kidney Perfusion Fluid Extracellular Vesicles as Markers of Graft Function
A. K. Rutman, S. Negi, N. Saberi, J. Tchervenkov, S. Paraskevas
Research Institute of the McGill University Health Institute, Montreal, QC, Canada
*Purpose: Kidney transplantation is a life-saving treatment for many patients with end-stage renal failure. Recently, machine perfusion of kidneys prior to transplantation has emerged as…
2020 American Transplant Congress
Kidney Transplantation from Extended-Criteria Donors: An Increased Risk of Ureteral and Urinary Complications? Study from 10279 Patients
B. Mesnard¹, M. Leroy², G. Karam¹, F. Neri³, P. Glemain¹, M. Perrouin-Verbe¹, S. De Vergie¹, O. Bouchot¹, J. Rigaud¹, D. Cantarovich¹, G. Blancho¹, M. Giral¹, J. Branchereau¹
¹Department of Urology, Chu Nantes, Nantes Université, ITUN, Nantes, France, ²Department of Methodology And Biostatistics, Nantes, Nantes Université, Methodology And Biostatistics Platform, Nantes, France, ³Department of Surgical Sciences, Nuffield Department of Surgical Sciences, Oxford Transplant Centre, Oxford University Hospitals, University of Oxford, Oxford, United Kingdom
*Purpose: Due to the increasing need for kidneys suitable to transplantation, the scientific comunity has expanded the donor population to include extended criteria donors (ECD).…

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