Articles tagged "Machine preservation"

2021 American Transplant Congress
Dual Lactate Clearance in the Liver Viability Assessment During Normothermic Machine Perfusion
M. Xu¹, F. Zhou¹, O. Ahmed¹, J. Shin¹, Y. Zhu¹, G. Upadhya¹, K. Byrnes², B. Wong¹, J. Kim¹, Y. Lin¹, W. Chapman¹
¹Department of Surgery, Washington University, St. Louis, MO, ²Department of Pathology and Immunology, Washington University, St. Louis, MO
*Purpose: Liver normothermic machine perfusion (NMP) has been increasingly performed as a tool of organ preservation and to evaluate donor function. The perfusate lactate clearance…
2021 American Transplant Congress
Recovery After Extended Static Cold Storage Preservation Using Subnormothermic Machine Perfusion in VCA
M. Goutard¹, R. J. de Vries¹, A. G. Lellouch¹, E. Lupon¹, C. Pendexter¹, S. N. Tessier¹, M. A. Randolph¹, L. Lantieri², C. L. Cetrulo¹, K. Uygun¹
¹Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, Boston, MA, ²Hôpital Européen Georges Pompidou, Paris, France
*Purpose: Vascularized composite allografts (VCA) are more sensitive to cold ischemia than solid organ transplants due to the remaining metabolism in skeletal muscle cells. In…
2020 American Transplant Congress
A Technique for Ex-Vivo Perfusion of Donor Kidneys for Transplantation in the Mouse
R. Plenter¹, S. Jain², J. J. Pomposelli¹, T. Nydam¹, A. Jani²
¹Pulmonary Division, University of Colorado, Aurora, CO, ²Renal Division, University of Colorado, Aurora, CO
*Purpose: Ex-vivo perfusion of donor kidneys is widely employed in the US and significantly reduces DGF. Development of a pre-clinical perfusion technique may provide an…
2020 American Transplant Congress
Mitochondrial Metabolism is Enriched Following Normothermic Ex-Vivo Kidney Perfusion of Grafts Procured Following Cardiac Death
P. Urbanellis¹, C. McEvoy¹, L. Mazilescu¹, S. Ganesh¹, R. John¹, I. Mucsi¹, A. Ghanekar¹, D. Bagli², A. Konvalinka¹, L. Robinson², M. Selzner¹
¹University Health Network, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) preservation has demonstrated superior graft outcomes for kidneys procured following donation-after-cardiac death (DCD) over static cold storage (SCS). To…
2020 American Transplant Congress
The Protective Effect of Hypothermic Oxygenated Machine Perfusion (HOPE) Onresuscitating Steatotic Liver and its Underlying Mechanism
F. Lin¹, F. Zhen¹, X. Yan¹, L. Wenjin¹, Y. Qifa²
¹Zhongnan Hospital of Wuhan University, Wuhan, China, ²Zhongnan Hospital of Wuhan University/The Third Xiangya Hospital of Central South University, Wuhan/Changsha, China
*Purpose: To analyze the impact of steatotic livers with conventional cold storage (CS) and hypothermic oxygenated perfusion (HOPE) approaches, and further to investigate the rescue…
2020 American Transplant Congress
Mesenchymal Stromal Cell Treatment of Kidneys During Normothermic Machine Perfusion is Safe and Feasible with Effective Traceability after Transplantation
K. Rozenberg¹, S. Lohmann², M. Pool³, M. Eijken⁴, U. Møldrup⁵, B. Møller⁶, J. Sierra-Parraga⁷, M. Hoogduijn⁷, L. Lo Faro¹, C. Moers³, J. Hunter¹, A. Keller², H. Leuvenink³, C. Baan⁷, R. Ploeg¹, B. Jespersen²
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, ³Department of Surgery, University Medical Center Groningen, Groningen, Netherlands, ⁴Department of Renal Medicine, Aarhus University, Aarhus, Denmark, ⁵Department of Urology, Aarhus University, Aarhus, Denmark, ⁶Department of Clinical Immunology, Aarhus University, Aarhus, Denmark, ⁷Department of Internal Medicine, Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands
*Purpose: Marginal kidneys are increasingly being accepted to decrease waiting time for a transplant. Normothermic machine perfusion (NMP) is a technique that allows delivery of…
2020 American Transplant Congress
Salvaging Discarded Livers with Normothermic Machine Perfusion: Is it Worth the Cost?
R. J. de Vries, S. Raigani, C. Carroll, Y. Chen, D. C. Chang, J. F. Markmann, K. Uygun, H. Yeh
Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: Normothermic machine perfusion (NMP) enables transplantation of discarded grafts with excellent outcomes in clinical trials. The cost of deploying NMP is often cited as…
2020 American Transplant Congress
Tetramethylpyrazine Activated Pparγ in Resuscitating the Liver Graft Donatedafter Cardiac Death
F. Zhen, F. Lin, Z. Lihua, L. Wenjin, X. Yan, C. Yong, Y. Qifa
Zhongnan Hospital of Wuhan University, Wuhan, China
*Purpose: to identify whether Tetramethylpyrazine (TMP) pretreatment can protect DCD grafts preserved during cold storage or/and HMP and transplanted.The protective mechanisms of TMP were also…
2020 American Transplant Congress
Proteomics and Metabolomics Technologies Reveal the Effect of Oxygen in Hypothermic Machine Perfusion to Alleviate Donation after Circulatory Death Liver Injury
X. Zeng¹, X. Fan², Y. Wang², Q. Xia¹, J. Liu¹, H. Li¹, Q. Ye², Z. Wang¹
¹Department of Urology, Union Hospital, Affiliated TongJi Medical College, Huazhong University of Science & Technology, Wuhan, China, ²Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Wuhan, China
*Purpose: To compare the effects of oxygenated and nitrogenated hypothermic machine perfusion on the preservation of donation after circulatory death (DCD) livers, and to explore…
2020 American Transplant Congress
Rouleaux Formation in Human Livers During Normothermic Machine Perfusion
M. Harris¹, S. Raigani², C. Albert³, M. Reschke³, C. Carroll², J. T. Langford¹, C. Edwards⁴, D. Mulligan⁴, D. Haakinson¹, K. Uygun², H. Yeh², G. Tietjen¹
¹Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT, ²Division of Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Yale School of Engineering and Applied Science, New Haven, CT, ⁴Surgery, Division of Transplantation, Yale New Haven Hospital, Yale School of Medicine, New Haven, CT
*Purpose: We recently discovered that red blood cells form rouleaux plugs in human kidney vasculature during normothermic machine perfusion (NMP) and are associated with poor…

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