ATC Abstracts

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Articles tagged "Machine preservation"

  • 2021 American Transplant Congress

    Machine Perfusion of Kidney Grafts in Simultaneous Liver Kidney Transplantation: National Trends and Outcomes

    A. Chang1, M. Chen1, P. Abt1, T. Bittermann2

    1Surgery, University of Pennsylvania, Philadelphia, PA, 2Gastroenterology, University of Pennsylvania, Philadelphia, PA

    *Purpose: In this study we analyze the SRTR liver data set to determine the trends in machine perfusion of kidney grafts prior to SLK and…
  • 2021 American Transplant Congress

    Impact of Machine Perfusion of the Heart on Abdominal Organ Procurement from Donation After Cardiac Death Donors

    C. Feizpour, C. Hwang, A. Shubin, J. Shah, L. DeGregoria, S. Hanish, P. Vagefi, M. MacConmara

    Department of Surgery, Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX

    *Purpose: Superior preservation with normothermic machine perfusion devices has been demonstrated in thoracic and abdominal allografts, especially DCD donation, where clinical utilization of DCD hearts…
  • 2021 American Transplant Congress

    Feasibility of Normothermic Ex Vivo Kidney Perfusion for Human Kidney Transplantation: First North American Results

    L. I. Mazilescu1, P. Urbanellis1, J. S. Kim1, A. Konvalinka1, T. W. Reichman1, L. A. Robinson2, A. Ghanekar1, M. Selzner1

    1Ajmera Transplant Program, Toronto General Hospital, Toronto, ON, Canada, 2Department of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada

    *Purpose: Normothermic ex vivo kidney perfusion is a novel preservation technique with promising results in porcine models and initial clinical results in one European center.…
  • 2021 American Transplant Congress

    Versatile Strategy to Enhance Nanomedicine Delivery to Graft Endothelial Cells

    C. Albert1, L. G. Bracaglia1, A. Koide2, J. DiRito1, T. Lysyy1, C. Edwards1, J. T. Langford1, D. Haakinson1, S. A. Hosgood3, M. L. Nicholson3, J. S. Pober1, W. M. Saltzman1, S. Kiode2, G. Tietjen1

    1Yale University, new haven, CT, 2Perlmutter Cancer Center, New York University, Langone Medical Center, New York, NY, 3University of Cambridge, Cambridge, United Kingdom

    *Purpose: Efficient delivery of therapeutics to graft endothelial cells (EC) can potentially render organs more resistant to injury, improving clinical outcomes. Specific targeting of polymeric…
  • 2021 American Transplant Congress

    Thrombolytic Therapy During Ex-Vivo Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury

    O. Haque1, S. Raigani2, I. Rosales2, C. Carroll2, T. M. Coe2, S. Baptista2, H. Yeh2, K. Uygun2, J. F. Markmann2

    1Surgery, Beth Israel Deaconess Medical Center, Boston, MA, 2Massachusetts General Hospital, Boston, MA

    *Purpose: A major limitation in expanding the use of DCD livers in transplantation are the higher rates of graft failure secondary to ischemic cholangiopathy. Warm…
  • 2021 American Transplant Congress

    Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability

    S. Raigani1, S. Baptista1, A. Ohman2, J. Santiago2, I. Rosales1, M. Heaney2, J. Boylan2, T. Coe1, K. Uygun1, J. Sanders2, H. Yeh1

    1Transplant Surgery, Massachusetts General Hospital, Boston, MA, 2Pediatric Endocrinology, Brown University, Providence, RI

    *Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…
  • 2021 American Transplant Congress

    Characterization of Kidney Small Extracellular Vesicles Released During Normothermic Machine Perfusion

    W. W. Woud1, A. Arykbaeva2, D. de Vries2, I. Alwayn2, K. Boer1, C. Baan1, M. Hoogduijn1, R. Minnee3

    1Internal Medicine, Nephorology and Transplantation, Erasmus MC, Rotterdam, Netherlands, 2Department of Surgery, LUMC, Leiden, Netherlands, 3Department of Surgery, Division of Hepato-Pancreato-Biliary and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands

    *Purpose: By characterizing and quantifying the dynamical release of kidney Extracellular Vesicles (EVs) during Normothermic Machine Perfusion (NMP), we aim to gain a better understanding…
  • 2021 American Transplant Congress

    Normothermic-Hyperthermic Machine Perfusion Could Increase Response to Pharmacological Intervention in Mitigation of Liver Steatosis

    F. Zhou, M. Xu, G. A. Upadhya, Y. Lin, W. C. Chapman

    Surgery, Washington University in St. Louis, St. Louis, MO

    *Purpose: To study the feasibility of mitigating rat liver steatosis with ex-situ normothermic-hyperthermic machine perfusion using a multi-drug ‘defatting’ combination.*Methods: 16 male Zucker obese rats…
  • 2021 American Transplant Congress

    Nrf2 Assessment in Discarded Liver Allografts: A Role in Allograft Function and Salvage

    O. Ahmed, M. Xu, F. Zhou, A. N. Wein, G. Upadhya, Y. Lin, W. Chapman

    Surgery, Washington University School of Medicine, Saint Louis, MO

    *Purpose: With mounting pressures to optimize organ availability for transplantation, there is a focus on reducing organ discard and attempting to resuscitate declined grafts for…
  • 2021 American Transplant Congress

    The Edge of Glory: Determinants of Success and Failure for Prolonged Cold Ischemia in Kidney Transplantation

    A. Turner1, M. Hamidi1, V. Ariyamuthu2, R. Harland1, B. Tanriover2

    1Surgery, Banner University of Arizona Medical Center, Tucson, AZ, 2Medicine, Banner University of Arizona Medical Center, Tucson, AZ

    *Purpose: Prolonged cold ischemia time (CIT>30 hours) is associated with an increased risk of primary non-function and early graft loss in kidney transplantation, although this…
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