Articles tagged "Machine preservation"

2021 American Transplant Congress
Impact of Machine Perfusion of the Heart on Abdominal Organ Procurement from Donation After Cardiac Death Donors
C. Feizpour, C. Hwang, A. Shubin, J. Shah, L. DeGregoria, S. Hanish, P. Vagefi, M. MacConmara
Department of Surgery, Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: Superior preservation with normothermic machine perfusion devices has been demonstrated in thoracic and abdominal allografts, especially DCD donation, where clinical utilization of DCD hearts…
2021 American Transplant Congress
Feasibility of Normothermic Ex Vivo Kidney Perfusion for Human Kidney Transplantation: First North American Results
L. I. Mazilescu¹, P. Urbanellis¹, J. S. Kim¹, A. Konvalinka¹, T. W. Reichman¹, L. A. Robinson², A. Ghanekar¹, M. Selzner¹
¹Ajmera Transplant Program, Toronto General Hospital, Toronto, ON, Canada, ²Department of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex vivo kidney perfusion is a novel preservation technique with promising results in porcine models and initial clinical results in one European center.…
2021 American Transplant Congress
Versatile Strategy to Enhance Nanomedicine Delivery to Graft Endothelial Cells
C. Albert¹, L. G. Bracaglia¹, A. Koide², J. DiRito¹, T. Lysyy¹, C. Edwards¹, J. T. Langford¹, D. Haakinson¹, S. A. Hosgood³, M. L. Nicholson³, J. S. Pober¹, W. M. Saltzman¹, S. Kiode², G. Tietjen¹
¹Yale University, new haven, CT, ²Perlmutter Cancer Center, New York University, Langone Medical Center, New York, NY, ³University of Cambridge, Cambridge, United Kingdom
*Purpose: Efficient delivery of therapeutics to graft endothelial cells (EC) can potentially render organs more resistant to injury, improving clinical outcomes. Specific targeting of polymeric…
2021 American Transplant Congress
Thrombolytic Therapy During Ex-Vivo Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury
O. Haque¹, S. Raigani², I. Rosales², C. Carroll², T. M. Coe², S. Baptista², H. Yeh², K. Uygun², J. F. Markmann²
¹Surgery, Beth Israel Deaconess Medical Center, Boston, MA, ²Massachusetts General Hospital, Boston, MA
*Purpose: A major limitation in expanding the use of DCD livers in transplantation are the higher rates of graft failure secondary to ischemic cholangiopathy. Warm…
2021 American Transplant Congress
Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability
S. Raigani¹, S. Baptista¹, A. Ohman², J. Santiago², I. Rosales¹, M. Heaney², J. Boylan², T. Coe¹, K. Uygun¹, J. Sanders², H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Pediatric Endocrinology, Brown University, Providence, RI
*Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…
2021 American Transplant Congress
Characterization of Kidney Small Extracellular Vesicles Released During Normothermic Machine Perfusion
W. W. Woud¹, A. Arykbaeva², D. de Vries², I. Alwayn², K. Boer¹, C. Baan¹, M. Hoogduijn¹, R. Minnee³
¹Internal Medicine, Nephorology and Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Department of Surgery, LUMC, Leiden, Netherlands, ³Department of Surgery, Division of Hepato-Pancreato-Biliary and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands
*Purpose: By characterizing and quantifying the dynamical release of kidney Extracellular Vesicles (EVs) during Normothermic Machine Perfusion (NMP), we aim to gain a better understanding…
2021 American Transplant Congress
Normothermic-Hyperthermic Machine Perfusion Could Increase Response to Pharmacological Intervention in Mitigation of Liver Steatosis
F. Zhou, M. Xu, G. A. Upadhya, Y. Lin, W. C. Chapman
Surgery, Washington University in St. Louis, St. Louis, MO
*Purpose: To study the feasibility of mitigating rat liver steatosis with ex-situ normothermic-hyperthermic machine perfusion using a multi-drug ‘defatting’ combination.*Methods: 16 male Zucker obese rats…
2021 American Transplant Congress
Nrf2 Assessment in Discarded Liver Allografts: A Role in Allograft Function and Salvage
O. Ahmed, M. Xu, F. Zhou, A. N. Wein, G. Upadhya, Y. Lin, W. Chapman
Surgery, Washington University School of Medicine, Saint Louis, MO
*Purpose: With mounting pressures to optimize organ availability for transplantation, there is a focus on reducing organ discard and attempting to resuscitate declined grafts for…
2021 American Transplant Congress
The Edge of Glory: Determinants of Success and Failure for Prolonged Cold Ischemia in Kidney Transplantation
A. Turner¹, M. Hamidi¹, V. Ariyamuthu², R. Harland¹, B. Tanriover²
¹Surgery, Banner University of Arizona Medical Center, Tucson, AZ, ²Medicine, Banner University of Arizona Medical Center, Tucson, AZ
*Purpose: Prolonged cold ischemia time (CIT>30 hours) is associated with an increased risk of primary non-function and early graft loss in kidney transplantation, although this…
2021 American Transplant Congress
Early Experience with Machine Retrograde Perfusion of Deceased Donor Kidneys: Short-term Outcomes of a Prospective Study
J. Zeng, Q. Zhong, S. Yin, Z. Jia, Z. Huang, Y. Fan, X. Wang, T. Lin, T. Song
Urology Institute and Organ Transplantation Center, West China Hospital, Chengdu, China
*Purpose: To maximize the utilization of potential kidneys, improving perfusion and preservation technique is necessary. This article mainly investigated the safety and efficacy of retrograde…

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