Articles tagged "Machine preservation"

2021 American Transplant Congress
Inhibition of Apoptosis During Ex Situ Liver Normothermic Machine Perfusion Decreases Reperfusion Injury and Improves Viability
S. Raigani¹, S. Baptista¹, A. Ohman², J. Santiago², I. Rosales¹, M. Heaney², J. Boylan², T. Coe¹, K. Uygun¹, J. Sanders², H. Yeh¹
¹Transplant Surgery, Massachusetts General Hospital, Boston, MA, ²Pediatric Endocrinology, Brown University, Providence, RI
*Purpose: Normothermic machine perfusion (NMP) is an ideal platform for delivery of novel therapeutics aimed at rehabilitation of discarded or marginal livers. We examined the…
2021 American Transplant Congress
Characterization of Kidney Small Extracellular Vesicles Released During Normothermic Machine Perfusion
W. W. Woud¹, A. Arykbaeva², D. de Vries², I. Alwayn², K. Boer¹, C. Baan¹, M. Hoogduijn¹, R. Minnee³
¹Internal Medicine, Nephorology and Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Department of Surgery, LUMC, Leiden, Netherlands, ³Department of Surgery, Division of Hepato-Pancreato-Biliary and Transplant Surgery, Erasmus MC, Rotterdam, Netherlands
*Purpose: By characterizing and quantifying the dynamical release of kidney Extracellular Vesicles (EVs) during Normothermic Machine Perfusion (NMP), we aim to gain a better understanding…
2021 American Transplant Congress
Normothermic-Hyperthermic Machine Perfusion Could Increase Response to Pharmacological Intervention in Mitigation of Liver Steatosis
F. Zhou, M. Xu, G. A. Upadhya, Y. Lin, W. C. Chapman
Surgery, Washington University in St. Louis, St. Louis, MO
*Purpose: To study the feasibility of mitigating rat liver steatosis with ex-situ normothermic-hyperthermic machine perfusion using a multi-drug ‘defatting’ combination.*Methods: 16 male Zucker obese rats…
2021 American Transplant Congress
Nrf2 Assessment in Discarded Liver Allografts: A Role in Allograft Function and Salvage
O. Ahmed, M. Xu, F. Zhou, A. N. Wein, G. Upadhya, Y. Lin, W. Chapman
Surgery, Washington University School of Medicine, Saint Louis, MO
*Purpose: With mounting pressures to optimize organ availability for transplantation, there is a focus on reducing organ discard and attempting to resuscitate declined grafts for…
2021 American Transplant Congress
The Edge of Glory: Determinants of Success and Failure for Prolonged Cold Ischemia in Kidney Transplantation
A. Turner¹, M. Hamidi¹, V. Ariyamuthu², R. Harland¹, B. Tanriover²
¹Surgery, Banner University of Arizona Medical Center, Tucson, AZ, ²Medicine, Banner University of Arizona Medical Center, Tucson, AZ
*Purpose: Prolonged cold ischemia time (CIT>30 hours) is associated with an increased risk of primary non-function and early graft loss in kidney transplantation, although this…
2021 American Transplant Congress
Early Experience with Machine Retrograde Perfusion of Deceased Donor Kidneys: Short-term Outcomes of a Prospective Study
J. Zeng, Q. Zhong, S. Yin, Z. Jia, Z. Huang, Y. Fan, X. Wang, T. Lin, T. Song
Urology Institute and Organ Transplantation Center, West China Hospital, Chengdu, China
*Purpose: To maximize the utilization of potential kidneys, improving perfusion and preservation technique is necessary. This article mainly investigated the safety and efficacy of retrograde…
2021 American Transplant Congress
Dual Lactate Clearance in the Liver Viability Assessment During Normothermic Machine Perfusion
M. Xu¹, F. Zhou¹, O. Ahmed¹, J. Shin¹, Y. Zhu¹, G. Upadhya¹, K. Byrnes², B. Wong¹, J. Kim¹, Y. Lin¹, W. Chapman¹
¹Department of Surgery, Washington University, St. Louis, MO, ²Department of Pathology and Immunology, Washington University, St. Louis, MO
*Purpose: Liver normothermic machine perfusion (NMP) has been increasingly performed as a tool of organ preservation and to evaluate donor function. The perfusate lactate clearance…
2021 American Transplant Congress
Recovery After Extended Static Cold Storage Preservation Using Subnormothermic Machine Perfusion in VCA
M. Goutard¹, R. J. de Vries¹, A. G. Lellouch¹, E. Lupon¹, C. Pendexter¹, S. N. Tessier¹, M. A. Randolph¹, L. Lantieri², C. L. Cetrulo¹, K. Uygun¹
¹Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, Boston, MA, ²Hôpital Européen Georges Pompidou, Paris, France
*Purpose: Vascularized composite allografts (VCA) are more sensitive to cold ischemia than solid organ transplants due to the remaining metabolism in skeletal muscle cells. In…
2021 American Transplant Congress
Machine Perfusion of Kidney Grafts in Simultaneous Liver Kidney Transplantation: National Trends and Outcomes
A. Chang¹, M. Chen¹, P. Abt¹, T. Bittermann²
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²Gastroenterology, University of Pennsylvania, Philadelphia, PA
*Purpose: In this study we analyze the SRTR liver data set to determine the trends in machine perfusion of kidney grafts prior to SLK and…
2021 American Transplant Congress
Impact of Machine Perfusion of the Heart on Abdominal Organ Procurement from Donation After Cardiac Death Donors
C. Feizpour, C. Hwang, A. Shubin, J. Shah, L. DeGregoria, S. Hanish, P. Vagefi, M. MacConmara
Department of Surgery, Division of Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: Superior preservation with normothermic machine perfusion devices has been demonstrated in thoracic and abdominal allografts, especially DCD donation, where clinical utilization of DCD hearts…

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