Articles tagged "Machine preservation"

2016 American Transplant Congress
Machine Perfusion (MP) at 21[deg]C Simulates Hibernation Metabolic Pathways in a Non-Hibernator Mammal.
B. Banan, S. Dobrowolski, G. Michalopoulos, P. Fontes.
University of Pittsburgh, Pittsburgh.
Background: Hibernation is a complex and multi stage process that leads to unique metabolic changes over an extended period of time. Regulatory genes and transcription…
2015 American Transplant Congress
Everolimus Initiation Immediately After Liver Transplantation: A Single-Center Experience
U. Herden, A. Galante, S. Pischke, L. Fischer, J. Li, M. Koch, E. Achilles, B. Nashan, M. Sterneck.
University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
BackgroundClinical trials in liver transplant (LTX) patients with randomization on day 30 to everolimus (EVR) show a benefit in renal function compared to calcineurin inhibitor…
2015 American Transplant Congress
Hypothermic Machine Perfusion Improves Kidney Viability through Amelioration of Vasospasm and Edema of Podocytes and Renal Tubular Epithelial Cells
Z. Zhong,¹ Z. Liu,¹ Z. Fu,² Y. Zhang,² D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Hypothermic machine perfusion (MP) may improve outcome after transplantation from donors after cardiac death (DCD) kidneys, but protective mechanisms of MP remain largely unknown. To…
2015 American Transplant Congress
Is the Pulsatile Kidney Preservation Machine a Vaulable Tool in Evaluating Kidney Suitability from Older Donors After Brain Death?
D. Paredes Zapata,¹ A. Ruiz Arranz,¹ C. Rodriguez Villar,¹ L. Peri Cussi,² A. Alcaraz Asensio,² R. Adalia Bartolome,¹ F. Oppenheimer Salinas.³
¹Donation and Transplant Coordination Section, Hospital Clinic, University of Barcelona, Barcelona, Spain; ²Urology Department, Hospital Clinic, University of Barcelona, Barcelona, Spain; ³Renal Transplant Unit, Hospital Clinic, Barcelona, Spain.
Introduction: Donors after Brain Death (DBD) older than 60 years old, have become 46.8% of our donor activity, with higher Discard Rate (DR). Assessment of…
2015 American Transplant Congress
Gradual Warming Up Perfusion Post Static Cold Storage Reduces Renal Injury
P. Mahboub,^3,1 P. Ottens,¹ R. Ploeg,² P. Martins,³ H. Leuvenink.¹
¹Surgery, UMCG, Groningen, Netherlands; ²Surgery, University of Oxford, Oxford, United Kingdom; ³Surgery, UMass, Worcester, MA.
We hypothesize that the sudden warm reperfusion after Cold Storage [CS] is detrimental for the graft and we therefore evaluated different warming-up procedures before reperfusion.Methods:Rat…
2015 American Transplant Congress
Establishment of a Novel Model for Hypothermic Machine Perfusion In Vivo in Rabbits
Z. Zhong,¹ Z. Liu,¹ R. Wang,¹ Z. Fu,² Y. Zhang,² Q. Hu,¹ K. Jin,¹ D. Ko,³ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; ²The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; ³Massachusetts General Hospital, Department of Urology, Boston, MA.
Background: Hypothermic machine perfusion (MP) could improve outcome after transplantation of DCD kidneys, but protective mechanisms of MP remain largely unknown. Therefore, this study aims…
2015 American Transplant Congress
Enhancing Kidney Function Following DCD Donation With Thrombolytic Therapy: A Preliminary Report of a Multicenter Prospective Quasi-Blinded Randomized Trial
K. Woodside,¹ D. Goldfarb,² J. Rabets,² E. Sanchez,¹ D. Lebovitz,³ J. Schulak,¹ J. Fung,² B. Eghtesad.²
¹Transplant Institute, University Hospitals Case Medical Center, Cleveland, OH; ²Transplant Center, Cleveland Clinic, Cleveland, OH; ³LIfebanc, Cleveland, OH.
Kidneys from donors following cardiac death (DCD) are at risk for inferior outcomes, possibly due to microthrombi and additional warm ischemia. We describe an organ…
2015 American Transplant Congress
Parameters of Machine Perfusion Evaluating Quality of Kidneys from DCD/ECD Donors
G. Chen, C. Wang, J. Qiu, M. Han, X. He, L. Chen.
Organ Transplant Center, The first affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Background Donors from donation after cardiac death(DCD) and expanded criteria donors(ECD) have poorer outcomes compared to standard deceased donors(SCD). It is important to evaluate quality…
2015 American Transplant Congress
Donor Lung Preservation With the Organ Care System® Promotes a Tissue Protective and Anti-Inflammatory Response During Transplantation
B. Wiegmann,¹ C. Falk,² M. Seyda,² C. Neudörfl,² A. Akhdar,² C. Kühn,¹ I. Tudorache,¹ M. Avsar,¹ A. Haverich,¹ G. Warnecke.¹
¹Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; ²Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.
ObjectivesWithin INSPIRE trial standard cold storage (SOC) is compared to normothermic, ventilated donor lung preservation (Organ-Care-System®, OCS). As lung preservation may influence immune mediators (IM),…
2015 American Transplant Congress
Ex Vivo Lung Perfusion: Revisit to the Optimal Oxygenation Circulating Lungs for Graft Preservation
K. Noda, S. Haam, J. D'Cunha, J. Luketich, C. Bermudez, N. Shigemura.
Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
AimAccumulating evidence supports increasing the role of ex vivo lung perfusion (EVLP). However, there are evidenced limitations as well as the adverse effects of current…