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Articles tagged "Machine preservation"

  • 2016 American Transplant Congress

    Lipid Metabolism and Preservation of Discarded Steatotic Human Livers Using 24 Hours Ex-Vivo Normothermic Machine Perfusion.

    Q. Liu, A. Nassar, G. Iuppa, B. Soliman, L. Buccini, M. Blum, T. Okamoto, T. Uso, A. Bennett, W. Baldwin, K. Abu-Elmagd, J. Fung, C. Miller, C. Quintini.

    Cleveland Clinic, Cleveland, OH.

    One primary reason to discard donor livers after procurement is severe steatosis. The impact of normothermic machine perfusion (NMP) on lipid metabolism and preservation of…
  • 2015 American Transplant Congress

    Normothermic Machine Perfusion (NMP) on Discarded Human Livers: The First Model in the US

    Q. Liu, A. Nassar, G. Iuppa, D. Urcuyo-Llanes, D. Sexton, T. Okamoto, T. Uso, A. Bennett, W. Baldwin, K. Abu-Elmagd, J. Fung, C. Miller, C. Quintini.

    Cleveland Clinic, Cleveland, OH.

    The benefit of NMP preservation has been reported in a number of animal studies. Herein we describe safety, feasibility and effectiveness of NMP on discarded…
  • 2015 American Transplant Congress

    Everolimus Initiation Immediately After Liver Transplantation: A Single-Center Experience

    U. Herden, A. Galante, S. Pischke, L. Fischer, J. Li, M. Koch, E. Achilles, B. Nashan, M. Sterneck.

    University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

    BackgroundClinical trials in liver transplant (LTX) patients with randomization on day 30 to everolimus (EVR) show a benefit in renal function compared to calcineurin inhibitor…
  • 2015 American Transplant Congress

    Hypothermic Machine Perfusion Improves Kidney Viability through Amelioration of Vasospasm and Edema of Podocytes and Renal Tubular Epithelial Cells

    Z. Zhong,1 Z. Liu,1 Z. Fu,2 Y. Zhang,2 D. Ko,3 Y. Wang,1 Q. Ye.1,2

    1Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, China; 2The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; 3Massachusetts General Hospital, Department of Urology, Boston, MA.

    Hypothermic machine perfusion (MP) may improve outcome after transplantation from donors after cardiac death (DCD) kidneys, but protective mechanisms of MP remain largely unknown. To…
  • 2015 American Transplant Congress

    Is the Pulsatile Kidney Preservation Machine a Vaulable Tool in Evaluating Kidney Suitability from Older Donors After Brain Death?

    D. Paredes Zapata,1 A. Ruiz Arranz,1 C. Rodriguez Villar,1 L. Peri Cussi,2 A. Alcaraz Asensio,2 R. Adalia Bartolome,1 F. Oppenheimer Salinas.3

    1Donation and Transplant Coordination Section, Hospital Clinic, University of Barcelona, Barcelona, Spain; 2Urology Department, Hospital Clinic, University of Barcelona, Barcelona, Spain; 3Renal Transplant Unit, Hospital Clinic, Barcelona, Spain.

    Introduction: Donors after Brain Death (DBD) older than 60 years old, have become 46.8% of our donor activity, with higher Discard Rate (DR). Assessment of…
  • 2015 American Transplant Congress

    Gradual Warming Up Perfusion Post Static Cold Storage Reduces Renal Injury

    P. Mahboub,3,1 P. Ottens,1 R. Ploeg,2 P. Martins,3 H. Leuvenink.1

    1Surgery, UMCG, Groningen, Netherlands; 2Surgery, University of Oxford, Oxford, United Kingdom; 3Surgery, UMass, Worcester, MA.

    We hypothesize that the sudden warm reperfusion after Cold Storage [CS] is detrimental for the graft and we therefore evaluated different warming-up procedures before reperfusion.Methods:Rat…
  • 2015 American Transplant Congress

    Establishment of a Novel Model for Hypothermic Machine Perfusion In Vivo in Rabbits

    Z. Zhong,1 Z. Liu,1 R. Wang,1 Z. Fu,2 Y. Zhang,2 Q. Hu,1 K. Jin,1 D. Ko,3 Y. Wang,1 Q. Ye.1,2

    1Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, China; 2The 3rd Xiangya Hospital of Central South University, Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology, Changsha, Hunan, China; 3Massachusetts General Hospital, Department of Urology, Boston, MA.

    Background: Hypothermic machine perfusion (MP) could improve outcome after transplantation of DCD kidneys, but protective mechanisms of MP remain largely unknown. Therefore, this study aims…
  • 2015 American Transplant Congress

    Enhancing Kidney Function Following DCD Donation With Thrombolytic Therapy: A Preliminary Report of a Multicenter Prospective Quasi-Blinded Randomized Trial

    K. Woodside,1 D. Goldfarb,2 J. Rabets,2 E. Sanchez,1 D. Lebovitz,3 J. Schulak,1 J. Fung,2 B. Eghtesad.2

    1Transplant Institute, University Hospitals Case Medical Center, Cleveland, OH; 2Transplant Center, Cleveland Clinic, Cleveland, OH; 3LIfebanc, Cleveland, OH.

    Kidneys from donors following cardiac death (DCD) are at risk for inferior outcomes, possibly due to microthrombi and additional warm ischemia. We describe an organ…
  • 2015 American Transplant Congress

    Parameters of Machine Perfusion Evaluating Quality of Kidneys from DCD/ECD Donors

    G. Chen, C. Wang, J. Qiu, M. Han, X. He, L. Chen.

    Organ Transplant Center, The first affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Background Donors from donation after cardiac death(DCD) and expanded criteria donors(ECD) have poorer outcomes compared to standard deceased donors(SCD). It is important to evaluate quality…
  • 2015 American Transplant Congress

    Donor Lung Preservation With the Organ Care System® Promotes a Tissue Protective and Anti-Inflammatory Response During Transplantation

    B. Wiegmann,1 C. Falk,2 M. Seyda,2 C. Neudörfl,2 A. Akhdar,2 C. Kühn,1 I. Tudorache,1 M. Avsar,1 A. Haverich,1 G. Warnecke.1

    1Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany; 2Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany.

    ObjectivesWithin INSPIRE trial standard cold storage (SOC) is compared to normothermic, ventilated donor lung preservation (Organ-Care-System®, OCS). As lung preservation may influence immune mediators (IM),…
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