2016 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) with a Hemoglobin Based Oxygen Carrier (HBOC) Solution Reprograms Dynamic Inflammation Networks When Compared to Cold Storage (CS) in a Porcine Liver Allograft Model.
University of Pittsburgh, Pittsburgh.
Introduction: Inflammatory markers have been mostly studied by standard statistical analysis focused on single component variations. This study aimed to compare SNMP with CS regarding…2015 American Transplant Congress
Gradual Warming Up Perfusion Post Static Cold Storage Reduces Renal Injury
We hypothesize that the sudden warm reperfusion after Cold Storage [CS] is detrimental for the graft and we therefore evaluated different warming-up procedures before reperfusion.Methods:Rat…2015 American Transplant Congress
Establishment of a Novel Model for Hypothermic Machine Perfusion In Vivo in Rabbits
Background: Hypothermic machine perfusion (MP) could improve outcome after transplantation of DCD kidneys, but protective mechanisms of MP remain largely unknown. Therefore, this study aims…2015 American Transplant Congress
Enhancing Kidney Function Following DCD Donation With Thrombolytic Therapy: A Preliminary Report of a Multicenter Prospective Quasi-Blinded Randomized Trial
Kidneys from donors following cardiac death (DCD) are at risk for inferior outcomes, possibly due to microthrombi and additional warm ischemia. We describe an organ…2015 American Transplant Congress
Parameters of Machine Perfusion Evaluating Quality of Kidneys from DCD/ECD Donors
Background Donors from donation after cardiac death(DCD) and expanded criteria donors(ECD) have poorer outcomes compared to standard deceased donors(SCD). It is important to evaluate quality…2015 American Transplant Congress
Donor Lung Preservation With the Organ Care System® Promotes a Tissue Protective and Anti-Inflammatory Response During Transplantation
ObjectivesWithin INSPIRE trial standard cold storage (SOC) is compared to normothermic, ventilated donor lung preservation (Organ-Care-System®, OCS). As lung preservation may influence immune mediators (IM),…2015 American Transplant Congress
Ex Vivo Lung Perfusion: Revisit to the Optimal Oxygenation Circulating Lungs for Graft Preservation
Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
AimAccumulating evidence supports increasing the role of ex vivo lung perfusion (EVLP). However, there are evidenced limitations as well as the adverse effects of current…2015 American Transplant Congress
Correlation Between Level of Biomarkers Measured in Perfusate of Machine-Preserved ECD/DCD Kidneys and Post-Transplant Graft Function
Background:DCD and ECD kidneys are associated with higher risk of failure compare to SCD kidneys. Therefore we see increasing need to identify sensitive tool to…2015 American Transplant Congress
Pre-Trasplant Perfusion With Mesenchymal Stromal Cells of Renal Graft Prevents Ischemia Injury Upregulating Gene Involved in Energy Saving
Background. Kidney ischemia from Donation after Circulatory Death shifts cells to anaerobic metabolism. Mesenchymal Stromal Cells (MSC) have immunomodulatory properties that are mediated by soluble…2015 American Transplant Congress
Normothermic Machine Perfusion (NMP) on Discarded Human Livers: The First Model in the US
Cleveland Clinic, Cleveland, OH.
The benefit of NMP preservation has been reported in a number of animal studies. Herein we describe safety, feasibility and effectiveness of NMP on discarded…
American Transplant Congress abstracts