Articles tagged "Machine preservation"

2016 American Transplant Congress
Ex-Vivo Normothermic Perfusion (EVNP) Attenuation of Kidney Ischemia-Reperfusion Injury (IRI): A Proposed Mechanism.
I. Palma,¹ S. Kabagambe,¹ Y. Smolin,¹ T. Boyer,¹ I. Palma,¹ O. Fiehn,² Y.-J. Chen,¹ J. Sageshima,¹ C. Santhanakrishnan,¹ C. Troppmann,¹ R. Perez.¹
¹Department of Surgery, University of California, Davis Medical Center, Sacramento, CA; ²Department of Molecular and Cellular Biology & Genome Center, University of California-Davis, Davis, CA.
Introduction: EVNP has the potential to repair deceased donor renal IRI. We hypothesize that EVNP may attenuate renal IRI via alteration of lipid metabolism.Methods: Eight…
2016 American Transplant Congress
Persufflation Improves Viability and Function of Porcine Kidneys Relative to Static Cold Storage.
C. Min,¹ L. Steyn,² A. Pandey,³ R. Harland,² J.-P. Galons,⁴ K. Papas.²
¹Physiology, University of Arizona, Tucson, AZ; ²Surgery, University of Arizona, Tucson, AZ; ³Electrical and Chemical Engineering, University of Arizona, Tucson, AZ; ⁴Medical Imaging, University of Arizona, Tucson, AZ.
The use of marginal organs demands optimization of organ storage and quality assessments prior to transplantation. Organs from donors after cardiac death (DCD) are exposed…
2016 American Transplant Congress
Subnormothermic Machine Perfusion (SNMP) with a Hemoglobin Based Oxygen Carrier (HBOC) Solution Reprograms Dynamic Inflammation Networks When Compared to Cold Storage (CS) in a Porcine Liver Allograft Model.
D. Sadowsky, R. Zamora, B. Banan, D. Barclay, J. Yin, Y. Vodovotz, P. Fontes.
University of Pittsburgh, Pittsburgh.
Introduction: Inflammatory markers have been mostly studied by standard statistical analysis focused on single component variations. This study aimed to compare SNMP with CS regarding…
2016 American Transplant Congress
Normothermic Perfusion of Livers Donated After Circulatory Death: A New Clinically Relevant Experimental Model.
Y. Cao,¹ H. Chew,^1,2 K. Fernandez,¹ L. Gao,¹ J. Villanueva,¹ M. Hicks,¹ P. Macdonald,^1,2 K. Dhital,^1,2 H. Pleass.³
¹Victor Chang Cardiac Research Institute, Sydney, NSW, Australia; ²Cardiac Transplant Unit, St. Vincent's Hospital, Sydney, NSW, Australia; ³The Department of Surgery, Westmead Hospital, Sydney, NSW, Australia.
Aim. Transplantation using livers donation after circulatory death (DCD) is associated with worse outcomes compared to using donation after brain death (DBD). Considerable research resources…
2016 American Transplant Congress
Signs of a Dying Organ: Beyond Resistance in Subnormothermic Kidney Perfusion.
M. Blum, D. Urcuyo, Q. Liu, B. Soliman, T. Okamoto, D. Goldfarb, C. Quintini.
Cleveland Clinic, Cleveland, OH.
Purpose: In hypothermic machine preservation of the kidney, resistance is often used to assess organ quality. Since no prognostic standard yet exists for subnormothermic ex-vivo…
2016 American Transplant Congress
Amino Acid (AA) Metabolism During Liver Allograft Preservation Comparing Subnormothermic Machine Perfusion (MP) Against Cold Storage (CS).
B. Banan, R. Lopez, C. Hughes, G. Michalopoulos, P. Fontes.
University of Pittsburgh, Pittsburgh.
Introduction: Liver is the major site for nitrogen metabolism. Most hepatic transcriptional activity is related to protein-specific synthesis. Liver preservation has a direct impact in…
2016 American Transplant Congress
Predictive Model of Delayed Graft Function in Machine Perfused Kidney Transplantation: Model Validation Using Decision Curve Analysis.
K. Ravindra,¹ S. Sanoff,¹ D. Vikraman,¹ U. Patel,¹ M. Ellis,¹ E. Squires,² D. Sudan,¹ W. Irish.¹
¹Surgery, Duke University, Durham, NC; ²Half Moon Bay, Raleigh.
Introduction: Predictive model for delayed graft function (DGF) was developed (Am J Transpl 2010; 10: 2279–86)excluding organs that were machine perfused (MP). Currently, approximately 50%…
2016 American Transplant Congress
The Influence of Static versus Machine Dynamic Perfusion Kidney Graft Preservation on Delayed Graft Function Incidence: A Prospective, Randomized Study.
H. Marinho Neto, V. Aires, J. Offerni, W. Luconi, P. Luconi, S. Braga, I. Noronha, R. Barsante, J. Moreira, A. Savina, L. Kuschnaroff, F. Lemos, A. Cuvello, P. Chocair, L. Moura, A. Silva Filho, I. Charpiot, M. Abbud Filho, M. Cunha, P. Malafonte, D. Demetrio, L. Miorin, A. Duboc Filho, A. Claudini, W. Aguiar, H. Tedesco, J. Medina Pestana.
Organ Procurement Organization, Kidney Hospital, São Paulo, Brazil.
Introduction: The incidence of delayed graft function (DGF) in Brazilians deceased kidney donor receptors is high; this is attributed to poor hemodynamic conditions on potential…
2016 American Transplant Congress
Hypothermic Machine Perfusion Ameliorates Vasospasm and Edema of Podocytes and Renal Tubular Epithelial Cells Through Upregulating Expression of Krüppel-Like Factors 2.
Z. Zhong,¹ D. Ko,² Y. Wang,¹ Q. Ye.¹
¹Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Wuhan, Hubei, China; ²Massachusetts General Hospital, Department of Urology, Harvard Medical School, Boston, MA.
Protective mechanisms of hypothermic machine perfusion (MP) remain largely unknown. Vascular branches of the renal arteries of 6 kidneys in 320 donors were unexpectedly injured…
2016 American Transplant Congress
Metabolic Recovery and Ex Vivo Simulation of Early Liver Reperfusion.
B. Bruinsma,¹ J. Avruch,² G. Sridharan,¹ P. Weeder,¹ N. Karimian,¹ J. Markmann,² K. Uygun,¹ H. Yeh.²
¹Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA; ²Transplant Center, Massachusetts General Hospital, Boston, MA.
Purpose. An urgent need for more liver grafts for transplantation has prompted the use of more suboptimal organs. Particularly in these more marginal livers adequate…