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Articles tagged "Machine preservation"

  • 2016 American Transplant Congress

    Ex-Vivo Normothermic Perfusion (EVNP) Attenuation of Kidney Ischemia-Reperfusion Injury (IRI): A Proposed Mechanism.

    I. Palma,1 S. Kabagambe,1 Y. Smolin,1 T. Boyer,1 I. Palma,1 O. Fiehn,2 Y.-J. Chen,1 J. Sageshima,1 C. Santhanakrishnan,1 C. Troppmann,1 R. Perez.1

    1Department of Surgery, University of California, Davis Medical Center, Sacramento, CA; 2Department of Molecular and Cellular Biology & Genome Center, University of California-Davis, Davis, CA.

    Introduction: EVNP has the potential to repair deceased donor renal IRI. We hypothesize that EVNP may attenuate renal IRI via alteration of lipid metabolism.Methods: Eight…
  • 2016 American Transplant Congress

    Persufflation Improves Viability and Function of Porcine Kidneys Relative to Static Cold Storage.

    C. Min,1 L. Steyn,2 A. Pandey,3 R. Harland,2 J.-P. Galons,4 K. Papas.2

    1Physiology, University of Arizona, Tucson, AZ; 2Surgery, University of Arizona, Tucson, AZ; 3Electrical and Chemical Engineering, University of Arizona, Tucson, AZ; 4Medical Imaging, University of Arizona, Tucson, AZ.

    The use of marginal organs demands optimization of organ storage and quality assessments prior to transplantation. Organs from donors after cardiac death (DCD) are exposed…
  • 2016 American Transplant Congress

    Subnormothermic Machine Perfusion (SNMP) with a Hemoglobin Based Oxygen Carrier (HBOC) Solution Reprograms Dynamic Inflammation Networks When Compared to Cold Storage (CS) in a Porcine Liver Allograft Model.

    D. Sadowsky, R. Zamora, B. Banan, D. Barclay, J. Yin, Y. Vodovotz, P. Fontes.

    University of Pittsburgh, Pittsburgh.

    Introduction: Inflammatory markers have been mostly studied by standard statistical analysis focused on single component variations. This study aimed to compare SNMP with CS regarding…
  • 2016 American Transplant Congress

    Normothermic Perfusion of Livers Donated After Circulatory Death: A New Clinically Relevant Experimental Model.

    Y. Cao,1 H. Chew,1,2 K. Fernandez,1 L. Gao,1 J. Villanueva,1 M. Hicks,1 P. Macdonald,1,2 K. Dhital,1,2 H. Pleass.3

    1Victor Chang Cardiac Research Institute, Sydney, NSW, Australia; 2Cardiac Transplant Unit, St. Vincent's Hospital, Sydney, NSW, Australia; 3The Department of Surgery, Westmead Hospital, Sydney, NSW, Australia.

    Aim. Transplantation using livers donation after circulatory death (DCD) is associated with worse outcomes compared to using donation after brain death (DBD). Considerable research resources…
  • 2016 American Transplant Congress

    Signs of a Dying Organ: Beyond Resistance in Subnormothermic Kidney Perfusion.

    M. Blum, D. Urcuyo, Q. Liu, B. Soliman, T. Okamoto, D. Goldfarb, C. Quintini.

    Cleveland Clinic, Cleveland, OH.

    Purpose: In hypothermic machine preservation of the kidney, resistance is often used to assess organ quality. Since no prognostic standard yet exists for subnormothermic ex-vivo…
  • 2016 American Transplant Congress

    Amino Acid (AA) Metabolism During Liver Allograft Preservation Comparing Subnormothermic Machine Perfusion (MP) Against Cold Storage (CS).

    B. Banan, R. Lopez, C. Hughes, G. Michalopoulos, P. Fontes.

    University of Pittsburgh, Pittsburgh.

    Introduction: Liver is the major site for nitrogen metabolism. Most hepatic transcriptional activity is related to protein-specific synthesis. Liver preservation has a direct impact in…
  • 2016 American Transplant Congress

    Predictive Model of Delayed Graft Function in Machine Perfused Kidney Transplantation: Model Validation Using Decision Curve Analysis.

    K. Ravindra,1 S. Sanoff,1 D. Vikraman,1 U. Patel,1 M. Ellis,1 E. Squires,2 D. Sudan,1 W. Irish.1

    1Surgery, Duke University, Durham, NC; 2Half Moon Bay, Raleigh.

    Introduction: Predictive model for delayed graft function (DGF) was developed (Am J Transpl 2010; 10: 2279–86)excluding organs that were machine perfused (MP). Currently, approximately 50%…
  • 2016 American Transplant Congress

    The Influence of Static versus Machine Dynamic Perfusion Kidney Graft Preservation on Delayed Graft Function Incidence: A Prospective, Randomized Study.

    H. Marinho Neto, V. Aires, J. Offerni, W. Luconi, P. Luconi, S. Braga, I. Noronha, R. Barsante, J. Moreira, A. Savina, L. Kuschnaroff, F. Lemos, A. Cuvello, P. Chocair, L. Moura, A. Silva Filho, I. Charpiot, M. Abbud Filho, M. Cunha, P. Malafonte, D. Demetrio, L. Miorin, A. Duboc Filho, A. Claudini, W. Aguiar, H. Tedesco, J. Medina Pestana.

    Organ Procurement Organization, Kidney Hospital, São Paulo, Brazil.

    Introduction: The incidence of delayed graft function (DGF) in Brazilians deceased kidney donor receptors is high; this is attributed to poor hemodynamic conditions on potential…
  • 2016 American Transplant Congress

    Hypothermic Machine Perfusion Ameliorates Vasospasm and Edema of Podocytes and Renal Tubular Epithelial Cells Through Upregulating Expression of Krüppel-Like Factors 2.

    Z. Zhong,1 D. Ko,2 Y. Wang,1 Q. Ye.1

    1Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Wuhan, Hubei, China; 2Massachusetts General Hospital, Department of Urology, Harvard Medical School, Boston, MA.

    Protective mechanisms of hypothermic machine perfusion (MP) remain largely unknown. Vascular branches of the renal arteries of 6 kidneys in 320 donors were unexpectedly injured…
  • 2016 American Transplant Congress

    Metabolic Recovery and Ex Vivo Simulation of Early Liver Reperfusion.

    B. Bruinsma,1 J. Avruch,2 G. Sridharan,1 P. Weeder,1 N. Karimian,1 J. Markmann,2 K. Uygun,1 H. Yeh.2

    1Center for Engineering in Medicine, Massachusetts General Hospital, Boston, MA; 2Transplant Center, Massachusetts General Hospital, Boston, MA.

    Purpose. An urgent need for more liver grafts for transplantation has prompted the use of more suboptimal organs. Particularly in these more marginal livers adequate…
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