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Articles tagged "Machine preservation"

  • 2018 American Transplant Congress

    Differences in Preservation Solution Formulas and Its Effects on Early Graft Function

    J. Brooks, P. Wiederhold, K. Jiles, A. Chiodo Ortiz, M. Dewey, M. Bailey, N. Koizumi, E. Rady, J. Ortiz.

    University of Toledo Medical Center, Toledo, OH; University of California-Los Angeles, Los Angeles, CA; Life Connection of Ohio, Maumee, OH; George Mason University, Fairfax, VA.

    Introduction: Machine perfusion has proven benefits and is common practice among transplant centers. However, the formulas of preservation solutions vary between organ procurement organizations (OPOs).…
  • 2017 American Transplant Congress

    Hypothermic Pulsatile Machine Perfusion for Human Pancreas Preservation.

    J. Branchereau, K. Renaudin, D. Cantarovich.

    Institute of Transplantation Urology, and Nephrology, Nantes University Hospital, Nantes, France

    Pancreas transplantation is one of the best treatment for selected insulin-dependent diabetic patients. The pancreas is high vulnerable to ischemic damage and re-perfusion injury which…
  • 2017 American Transplant Congress

    Preliminary Results of Clinical Normothermic Ex Vivo Liver Perfusion in a North American Setting.

    M. Bral,1 B. Gala-Lopez,1 D. Bigam,1 N. Kneteman,1 A. Malcolm,1 S. Livingstone,1 A. Andres,1 J. Emamaullee,1 L. West,1 P. Friend,2 A. Shapiro.1

    1Department of Surgery, University of Alberta, Edmonton, AB, Canada; 2Department of Surgery, Nuffield Department of Surgical Sciences, Oxford, United Kingdom; 3Oxford Institute of Biomedical Engineering, Oxford, United Kingdom; 4OrganOx, Oxford, United Kingdom

    Outcomes of a first clinical normothermic machine perfusion (NMP) UK liver trial demonstrated feasibility and clear safety, with improved liver function when compared to standard…
  • 2017 American Transplant Congress

    Split Liver Ex-situ Oxygenated Machine Perfusion: A Novel Approach to Organ Preservation and Treatment.

    N. Karimian,1 V. Huang,1 S. Geerts,1 S. Mert,1 I. Beijert,2 F. Fontan,1 M. Aburawi,1 R. Porte,2 K. Uygun,1 J. Markmann,1 H. Yeh.1

    1Division of Transplantation, Massachusetts General Hospital, Boston; 2Division of Transplantation, University Medical Center Groningen, Groningen, Netherlands

    Ex-situ machine perfusion (MP) is a promising method to improve organ viability prior to transplantation and is being used in various clinical trials worldwide. However,…
  • 2017 American Transplant Congress

    Treating Ischemically Damaged Porcine Kidneys with Mesenchymal Stromal Cells During Normothermic Machine Perfusion.

    M. Pool,1 J. Sierra Parraga,2 M. Roemeling-van Rhijn,3 M. Reinders,4 M. Hoogduijn,2 R. Ploeg,1,5 H. Leuvenink,1 C. Moers.

    1Surgery, UMCG, Groningen, Netherlands; 2Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands; 3Internal Medicine, UMCG, Groningen, Netherlands; 4Nephrology, LUMC, Leiden, Netherlands; 5Oxford Transplant Centre, University of Oxford, Oxford, United Kingdom

    Normothermic machine perfusion (NMP) could provide superior organ preservation and offers the unique opportunity for interventions to an isolated kidney prior to transplantation. There is…
  • 2017 American Transplant Congress

    Immediate vs. Delayed Kidney Implantation Is Associated with Improved Kidney Graft Survival in Combined Liver-Kidney Transplantation.

    J. Halldorson, S. Rayhill.

    Transplant Surgery, University of California, San Diego, CA; Transplant Surgery, University of Washington, Seattle, WA

    Simultaneous Liver/Kidney transplantation involves significant potential stress for the kidney graft. A surgeon needs to decide whether to place the kidney immediately to minimize cold…
  • 2017 American Transplant Congress

    First Report of Human Liver Transplantation After Normothermic Machine Perfusion (NMP) in the United States.

    Q. Liu, B. Soliman, G. Iuppa, A. Nassar, A. Hassan, T. Diago Uso, K. Hashimoto, F. Aucejo, M. Fujiki, B. Eghtesad, J. Cywinski, S. Irefin, J. Fung, K. Abu-Elmagd, C. Miller, C. Quintini.

    Cleveland Clinic, Cleveland

    NMP is a novel preservation method for liver grafts. We transplanted 10 human livers after NMP to test the safety and feasibility of NMP on…
  • 2017 American Transplant Congress

    Cost-Effectiveness of Renal Machine Perfusion Use After Long Cold Ischemia Time.

    A. Matos,1 D. Malheiro,3 S. Morgado,1 L. Requi[acirc]o-Moura,1 M. Souza-Durão,1,2 E. Tonato,1 M. Nogueira,1 M. Borrelli,1 A. Pacheco-Silva.1,2

    1Renal Transplant, Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Nephrology, Universidade Federal de São Paulo, São Paulo, Brazil; 3Health Economics Department, Hospital Israelita Albert Einstein, São Paulo, Brazil

    High cold ischemia time (CIT) and inadequate care of donors in Brazil lead to a high incidence of delayed graft function (DGF), 60%-70%, and as…
  • 2017 American Transplant Congress

    36 Hours of Ex-Vivo Warm Cellular Perfusion of Swine Liver Using the Organ Care System (OCS™) Liver with Excellent Functional, Metabolic and Histological Outcomes.

    J. Magliocca,1 J. Markmann,2 M. Abouljoud,3 M. Ghobrial,4 A. Demetris.5

    1Division of Transplant Surgery Department of Surgery, The Emory Transplant Center, Atlanta, GA; 2Department of Surgery Division of Transplantation, Massachusetts General Hospital, Boston, MA; 3Transplant Institute and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; 4Surgery - General, Houston Methodist Hospital, Houston, TX; 5Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA

    Cold storage preservation results in ischemia/reperfusion injury to the donor liver, it lacks any resuscitative or assessment capabilities. The OCS™ Liver maintains livers in a…
  • 2017 American Transplant Congress

    Results of the Initial Phase of the Portable Organ Care System (OCS™) Liver PROTECT Pivotal Trial.

    J. Markmann,1 M. Ghobrial,3 J. Magliocca,4 A. Demetris,5 M. Abouljoud.2

    1Department of Surgery-Division of Transplantation, Massachusetts General Hospital, Boston, MA; 2Transplant Institute and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; 3Sherrie & Alan Conover Center for Liver Disease & Transplantation, Houston Methodist Hospital, Houston, TX; 4Division of Transplant Surgery Department of Surgery, The Emory Transplant Center, Atlanta, GA; 5Department of Transplant Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA

    PurposeThe OCS Liver PROTECT Trial is a prospective, international, randomized controlled trial to evaluate the impact of using portable ex-vivo warm, oxygenated blood perfusion using…
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