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Articles tagged "Machine preservation"

  • 2018 American Transplant Congress

    Impact of Pulsatile Perfusion Machine on Postoperative Outcomes in Standard Criteria Donor Kidney Transplants

    S. Costa,1,2 T. Sandes-Freitas,1,2 P. Fernandes,2 R. Esmeraldo.1

    1Hospital Geral de Fortaleza, Fortaleza, Brazil; 2Universidade Federal do Ceara, Fortaleza, Brazil.

    Introduction: Delayed graft function (DGF) negatively impacts kidney transplant (KT) outcomes. Our aim was to assess the impact of pulsatile machine perfusion (MP) on KT…
  • 2017 American Transplant Congress

    Development of an Automatic Regulated Normothermic Kidney Preservation Device for Long-Term Organ Perfusion.

    A. Weissenbacher,1 O. Boubriak,2 L. Lo Faro,1 R. Ploeg,1 J. Hunter,1 D. Voyce,3 N. Mikov,3 A. Cook,3 C. Coussios,2 P. Friend.1

    1Nuffield Department of Surgical Sciences, Oxford Transplant Centre, University of Oxford, Oxford, United Kingdom; 2Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom; 3OrganOx Limited, Magdalen Centre, Oxford Science Park, Oxford, United Kingdom

    BackgroundNormothermic kidney perfusion for a period of 24 hours or longer would offer significant clinical advantages. It would enable clinicians to investigate the condition of…
  • 2017 American Transplant Congress

    Human Organs Allocated for Research – Maximising Use of a Precious Resource Using a New Ex Vivo Model of Reperfusion Injury.

    B. Sandhu, H. Bishop, D. Loja, N. Galloway-Phillips, J. Crawley, C. Pusey, V. Papalois.

    Imperial College, London, United Kingdom

    Purpose: A greater interest in machine perfusion strategies for all solid organs has led to a substantial increase in the allocation and utilisation of human…
  • 2017 American Transplant Congress

    Impact of STEEN vs Gelofusine as Perfusate During Normothermic Ex Vivo liver Perfusion on Outcome of Pig Liver Transplantation.

    I. Linares, D. Kollmann, J. Echeverri, M. Kaths, R. Rosales, C. Bruguera, M. Hamar, P. Urbanellis, S. Ganesh, N. Selzner, M. Selzner.

    Multiorgan Transplant Program, Toronto General Hospital, Toronto, ON, Canada

    European and North American clinical trials have used two different perfusate solutions for normothermic ex vivo liver perfusion (NEVLP): Gelofusine (bovine derived gelatin-based solution) and…
  • 2017 American Transplant Congress

    Extended Ex Vivo Kidney Perfusion Using Hemopure as an Oxygen Carrier: A Method to Preserve, Assess and Repair Discarded Organs.

    F. Fontan, M. Aburawi, N. Karimian, K. Uygun, F. Delmonico, H. Yeh, J. Markmann.

    Transplant Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background: Hypothermic non-oxygenated machine perfusion (HMP) is commonly used in kidney preservation, providing some advantage over static cold storage, as well as flow and resistance…
  • 2017 American Transplant Congress

    Hypothermic Pulsatile Machine Perfusion for Human Pancreas Preservation.

    J. Branchereau, K. Renaudin, D. Cantarovich.

    Institute of Transplantation Urology, and Nephrology, Nantes University Hospital, Nantes, France

    Pancreas transplantation is one of the best treatment for selected insulin-dependent diabetic patients. The pancreas is high vulnerable to ischemic damage and re-perfusion injury which…
  • 2017 American Transplant Congress

    Preliminary Results of Clinical Normothermic Ex Vivo Liver Perfusion in a North American Setting.

    M. Bral,1 B. Gala-Lopez,1 D. Bigam,1 N. Kneteman,1 A. Malcolm,1 S. Livingstone,1 A. Andres,1 J. Emamaullee,1 L. West,1 P. Friend,2 A. Shapiro.1

    1Department of Surgery, University of Alberta, Edmonton, AB, Canada; 2Department of Surgery, Nuffield Department of Surgical Sciences, Oxford, United Kingdom; 3Oxford Institute of Biomedical Engineering, Oxford, United Kingdom; 4OrganOx, Oxford, United Kingdom

    Outcomes of a first clinical normothermic machine perfusion (NMP) UK liver trial demonstrated feasibility and clear safety, with improved liver function when compared to standard…
  • 2017 American Transplant Congress

    Split Liver Ex-situ Oxygenated Machine Perfusion: A Novel Approach to Organ Preservation and Treatment.

    N. Karimian,1 V. Huang,1 S. Geerts,1 S. Mert,1 I. Beijert,2 F. Fontan,1 M. Aburawi,1 R. Porte,2 K. Uygun,1 J. Markmann,1 H. Yeh.1

    1Division of Transplantation, Massachusetts General Hospital, Boston; 2Division of Transplantation, University Medical Center Groningen, Groningen, Netherlands

    Ex-situ machine perfusion (MP) is a promising method to improve organ viability prior to transplantation and is being used in various clinical trials worldwide. However,…
  • 2017 American Transplant Congress

    Treating Ischemically Damaged Porcine Kidneys with Mesenchymal Stromal Cells During Normothermic Machine Perfusion.

    M. Pool,1 J. Sierra Parraga,2 M. Roemeling-van Rhijn,3 M. Reinders,4 M. Hoogduijn,2 R. Ploeg,1,5 H. Leuvenink,1 C. Moers.

    1Surgery, UMCG, Groningen, Netherlands; 2Internal Medicine, Erasmus Medical Center, Rotterdam, Netherlands; 3Internal Medicine, UMCG, Groningen, Netherlands; 4Nephrology, LUMC, Leiden, Netherlands; 5Oxford Transplant Centre, University of Oxford, Oxford, United Kingdom

    Normothermic machine perfusion (NMP) could provide superior organ preservation and offers the unique opportunity for interventions to an isolated kidney prior to transplantation. There is…
  • 2017 American Transplant Congress

    Immediate vs. Delayed Kidney Implantation Is Associated with Improved Kidney Graft Survival in Combined Liver-Kidney Transplantation.

    J. Halldorson, S. Rayhill.

    Transplant Surgery, University of California, San Diego, CA; Transplant Surgery, University of Washington, Seattle, WA

    Simultaneous Liver/Kidney transplantation involves significant potential stress for the kidney graft. A surgeon needs to decide whether to place the kidney immediately to minimize cold…
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