Articles tagged "Machine preservation"

2019 American Transplant Congress
Brief Normothermic Machine Perfusion is Superior to Cold Storage Alone – A Paired Discarded Human Kidney Analysis
A. Hameed¹, E. Patrick², D. B. Lu¹, C. P'ng¹, M. Hu², Y. Chew², R. De Roo¹, L. Yuen¹, W. Hawthorne¹, N. Rogers¹, H. Pleass¹
¹Westmead Hospital, Sydney, Australia, ²Westmead Institute for Medical Research, Sydney, Australia
*Purpose: The use of marginal has increased due to ongoing donor shortages. These kidneys have higher rates of graft discard after procurement, and also have…
2019 American Transplant Congress
CD47 Blockade Promotes Hepatic Macrophage Polarization toward M1 during Normothermic Machine Perfusion of Discarded Human Livers
M. Xu¹, F. Zhou¹, S. Garcia-Aroz¹, B. Banan¹, W. Yang², G. Upadhya¹, K. Byrnes³, B. Wong¹, P. Manning⁴, Y. Lin¹, W. Chapman¹
¹Department of Surgery, Washington University School of Medicine, St. Louis, MO, ²Department of Genetics, Washington University School of Medicine, St. Louis, MO, ³Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, ⁴Arch Oncology, St. Louis, MO, USA, St. Louis, MO
*Purpose: M1 macrophages have been shown to be able to phagocytize dead cells after ischemia-reperfusion injury (IRI). This study investigated the therapeutic effect of CD47…
2018 American Transplant Congress
Ex Vivo Bloodless Oxygen Carrier for Perfusion of DCD Kidneys during Subnormothermic Storage
P. Luke,^1,2 M. Richard-Mohamed,² A. Haig,³ R. Mayer,² S. Aquil,² A. Sener,² A. Jevnikar,^1,2 R. Bhattacharjee.^1,2
¹Matthew Mailing Centre for Translational Transplant Studies, London, ON, Canada; ²Multi-Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; ³Pathology and Laboratory Medicine, London Health Sciences Centre, London, ON, Canada.
Background: Non-oxygenated static or machine perfusion in cold (4[deg]C) remains the gold standard in transplantation and an optimal method of oxygen delivery to ischemic kidneys…
2018 American Transplant Congress
Biliary pH, Bicarbonate and Glucose Are Suitable Biomarkers of Bile Duct Viability during Normothermic Machine Perfusion of Human Donor Livers
A. Matton,^1,2 Y. de Vries,^1,2 L. Burlage,^1,2 R. van Rijn,^1,2 A. Gouw,³ V. de Meijer,¹ T. Lisman,² R. Porte.¹
¹Department of Surgery, Section Hepatopancreatobiliary Surgery & Liver Transplantation, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ²Surgical Research Laboratory, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; ³Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Background: Normothermic machine perfusion (NMP) is rapidly making its way into the clinic and can be used for viability assessment of human donor livers prior…
2018 American Transplant Congress
Supercooling of Human Livers to Extend the Preservation Time for Transplantation
R. de Vries,^1,2 S. Tessier,^1,2 P. Banik,^1,2 S. Ozer,^1,2 S. Napgal,^1,2 S. Cronin,^1,2 J. Markmann,^1,2 H. Yeh,^1,2 K. Uygun.^1,2
¹Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Center for Engineering in Medicine, Harvard Medical School, Boston, MA.
Introduction: Extending the maximum preservation time of donor organs could dramatically improve the outcome of organ transplantation. Static cold storage (SCS) at +5[deg]C is the…
2018 American Transplant Congress
Differences in Preservation Solution Formulas and Its Effects on Early Graft Function
J. Brooks, P. Wiederhold, K. Jiles, A. Chiodo Ortiz, M. Dewey, M. Bailey, N. Koizumi, E. Rady, J. Ortiz.
University of Toledo Medical Center, Toledo, OH; University of California-Los Angeles, Los Angeles, CA; Life Connection of Ohio, Maumee, OH; George Mason University, Fairfax, VA.
Introduction: Machine perfusion has proven benefits and is common practice among transplant centers. However, the formulas of preservation solutions vary between organ procurement organizations (OPOs).…
2018 American Transplant Congress
Factors Predicting Viability Achievement on Discarded Donor Livers Submitted to Extra-Corporeal Machine Perfusion
Y. Boteon,^1,2 R. Laing,^1,2 A. Schlegel,² J. Attard,^1,2 L. Wallace,¹ A. Smith,² T. Perera,² J. Isaac,² D. Mirza,² S. Afford,¹ H. Mergental.²
¹National Institute for Health Research, Birmingham Liver Biomedical Research Centre, University of Birmingham, Institute of Immunology and Immunotherapy, Birmingham, United Kingdom; ²Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United Kingdom.
Background: Ex-vivo machine perfusion of livers (MP) may offer superior preservation for marginal donor organs. During normothermic machine perfusion (NMP) is possible to assess liver…
2018 American Transplant Congress
Viability Outcomes for Donor Livers Discarded Due to Steatosis Following Extra-Corporeal Machine Perfusion of the Liver
Y. Boteon,^1,2 R. Laing,^1,2 D. Neil,² A. Schlegel,² J. Attard,^1,2 G. Reynold,¹ P. Muiesan,² D. Mirza,² S. Afford,¹ H. Mergental.²
¹National Institute for Health Research, Birmingham Liver Biomedical Research Centre, University of Birmingham, Institute of Immunology and Immunotherapy, Birmingham, United Kingdom; ²Liver Unit, Queen Elizabeth Hospital, University Hospitals Birmingham, Birmingham, United Kingdom.
Background: Steatosis is the main reason for discarding donor livers worldwide. Ex-vivo machine perfusion offers superior preservation for marginal organs and permits viability testing during…
2018 American Transplant Congress
Molecular Injury and Repair Assessment in Ex Vivo Perfused Swine Heart Transplants
N. Herbers, S. Hatami, P. Dromparis, J. Nagendran, M. Mengel, D. Freed, B. Adam.
University of Alberta, Edmonton, Canada.
Background: Cardiac transplantation is a life-saving intervention for advanced heart failure but it is unfortunately limited by a critical shortage of suitable donor organs and…
2018 American Transplant Congress
Use of Perfusion Machine after Long Cold Ischemia Time: 3 Years Results
A. Matos,¹ L. Requião-Moura,¹ E. Tonato,¹ M. Souza-Durão,^1,2 M. Borrelli,¹ M. Nogueira,¹ P. Rubio,¹ A. Pacheco-Silva.^1,2
¹Transplant, Hospital Israelita Albert Einstein, São Paulo, Brazil; ²Nephrology, Universidade Federal de São Paulo, São Paulo, Brazil.
The rate of delayed graft function (DGF) in Brazil is very high, reaching 80%. This is due to the long cold ischemia time (TIF) and…