2019 American Transplant Congress
Prevention of Graft Ischemia-Reperfusion Injury in Ischemia-Free Liver Transplantation
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Graft ischemia-reperfusion injury (IRI) is an inevitable event in organ transplantation, which often leads to a number of complications and even patient deaths. We…2019 American Transplant Congress
Hypothermic Machine Perfusion Protects Donation After Cardiac Deathliver Graft Through Gstm1-mediated Cytochrome P450 Exogenous Substance Metabolism Pathway
Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases, Wuhan, China
*Purpose: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…2019 American Transplant Congress
Sirna Uptake During Ex Vivo Hypothermic And Normothermic Liver Machine Perfusion: Beginning Of A New Era Of Organ Preservation
*Purpose: RNA interference (RNAi) is a natural gene modulation process that was recently approved for clinical use and has great potential for treatment of many…2019 American Transplant Congress
Normothermic Machine Perfusion of Human Kidneys without an Oxygen Carrier
Massachusetts General Hospital, Boston, MA
*Purpose: Normothermic machine perfusion (NMP) is a promising strategy for pre-transplant reconditioning and viability assessment of marginal renal grafts. All current clinical kidney NMP protocols…2019 American Transplant Congress
Brief Normothermic Machine Perfusion is Superior to Cold Storage Alone – A Paired Discarded Human Kidney Analysis
1Westmead Hospital, Sydney, Australia, 2Westmead Institute for Medical Research, Sydney, Australia
*Purpose: The use of marginal has increased due to ongoing donor shortages. These kidneys have higher rates of graft discard after procurement, and also have…2019 American Transplant Congress
CD47 Blockade Promotes Hepatic Macrophage Polarization toward M1 during Normothermic Machine Perfusion of Discarded Human Livers
*Purpose: M1 macrophages have been shown to be able to phagocytize dead cells after ischemia-reperfusion injury (IRI). This study investigated the therapeutic effect of CD47…2019 American Transplant Congress
Machine Perfusion Allows Use of High KDPI and Prolonged Cold Ischemia Time in Deceased Donors: A Single Center Effort to Decrease Discard Rates
Miami Transplant Institute, University of Miami, Miami, FL
*Purpose: Discard rates of deceased donor kidney transplants(DDKT)rises as the kidney donor profile index(KDPI)increases,and approaches 60%for KDPI of >85%.Pulsatile machine perfusion(MP)allows use of kidneys with…2019 American Transplant Congress
Metabolic Profiling of Steatotic Human Livers during Ex-Vivo Normothermic Machine Perfusion
*Purpose: Nearly 40-60% of discarded livers are due to steatosis because of poor recovery from ischemia-reperfusion injury and compromised post-transplant function. We evaluated steatotic (ST)…2019 American Transplant Congress
Elevated Podocyte-specific Urinary Extracellular Vesicles In Patients With Fsgs Recurrence After Kidney Transplantation
University of California Irvine, Orange, CA
*Purpose: Kidney graft failure is a major concern in patients with kidney transplantation. Patients who suffered graft failure are at a higher risk for mortality…2019 American Transplant Congress
Ischemia-Free Liver Transplantation Protects Bile Duct from Ischemia/Reperfusion Injury
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Ischemia-free liver transplantation (IFLT), based on normothermic machine perfusion and innovations in surgical technique, can provide continue blood supply from procurement to implantation that…
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