2017 American Transplant Congress
Innate Lymphoid Cells Play a Critical Role in Regulating Allograft Homeostasis in Human Intestinal Transplantation.
Transplant, MedStar Georgetown Transplant Institute, Washington, DC
A. The role of recently discovered innate lymphoid cells (ILCs) in intestinal transplant (ITx) patients is poorly understood. Here, we postulate that intestinal ILC subsets…2017 American Transplant Congress
Ectopic Lymphoid Structures Are Present in Type I T-Cell Mediated Kidney Transplant Rejection.
BackgroundIn renal transplantation, many allograft recipients develop donor-specific antibodies associated with an increased risk for graft rejection. Current immunosuppressive agents are principally aimed at T-cell-mediated…2017 American Transplant Congress
A Single Skin Commensal Strain Is Sufficient to Accelerate Skin Transplant Rejection.
The kinetics of graft rejection depend mostly on the extent of genetic disparities between organ donor and recipient, but appreciation that environmental factors may also…2017 American Transplant Congress
Pre-TACE Immune Status Correlates with Treatment Response and Tumor Biology in HCC as a Bridge to Transplant.
Purpose:Immune factors are pivotal against disease progression after transplant in hepatocellular carcinoma (HCC). With chemoembolization (TACE) as a bridge to liver transplant, this study compares…2016 American Transplant Congress
Memory Regulatory T Cell: A Potential Actor in Immunological Operational Tolerance in Kidney-Transplant Patients via the ATP Degradation into Adenosine.
Regulatory T cells (Tregs) are essential actors in the control of self-tolerance and exacerbated inflammation. In experimental transplantation Tregs are critical to achieve alloantigen tolerance…2016 American Transplant Congress
Neutrophil-to-Lymphocyte Ratio as a Predictor of Polyomavirus BK Nephropathy in Kidney Transplant Patients.
Background: Neutrophil-to-lymphocyte ratio (NLR) is an index for systemic inflammatory response, and has been reported to be a prognostic marker in the patients with malignancies…2016 American Transplant Congress
Innate Lymphoid Cells Play a Key Role in Controlling Antimicrobial Defense in Intestinal Transplant Recipients.
MedStar Georgetown Transplant Institute, Washington DC.
A. Infectious complications are the leading cause of death early after intestinal transplantation (ITx). Etiologies underlying this remain unclear. Innate lymphoid cells (ILCs) have very…2016 American Transplant Congress
Evaluation of a Novel Global Immunity Assay to Predict Infections in Organ Transplant Recipients.
Multi-Organ Transplant, University Health Network, Toronto, Canada.
BackgroundSimple standardized measures of global immunity may help predict the risk of infections post-transplant. The Quantiferon-Monitor (QFM) test is a novel interferon-γ (IFN-γ) release assay…2016 American Transplant Congress
Direct IL-33 Stimulation of T Regulatory Cells via Suppression of Tumorigenicity 2 (ST2) Is Required for Effective Control of Alloimmune Responses.
Background: IL-33 is a pleotropic cytokine that can protect against cardiac transplant rejection by expanding regulatory T cells (Treg), particularly a Treg subset expressing the…2016 American Transplant Congress
NAD+ Promotes Allograft Survival Independently of CD4+CD25+Foxp3+ Regulatory T Cells.
CD4+CD25+Foxp3+ regulatory T cells (Tregs) play a central role in the maintenance of immune tolerance and T cell homeostasis. It is known that Tregs promote…
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