ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lymphocytes"

  • 2020 American Transplant Congress

    Preventing Allograft Rejection by Circrna FSCN1 Mediated Tolerogenic Dendritic Cells

    B. Wang, Q. Zhou, V. Veramkovich, A. Greasley, S. Li, X. Zheng

    Pathology, University of Western Ontario-LHSC, London, ON, Canada

    *Purpose: Induction of immune tolerance is a major challenge in heart transplants. There is no robust treatment with fewer side effects for preventing chronic rejection.…
  • 2020 American Transplant Congress

    Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells

    B. Kim1, E. Kim2, J. Kim2, H. Choi3, H. Lee2, J. Lee4, M. Kim4, Y. Kim4, K. Huh4

    1Department of Internal Medicine, Yonsei University Health System, Seoul, Korea, Republic of, 2The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, 4Department of Transplantation Surgery, Yonsei University Health System, Seoul, Korea, Republic of

    *Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…
  • 2020 American Transplant Congress

    Characterization of Laminin Alpha 4 Conditional Knockout Mice: Model for Immune Stimulation

    M. W. Shirkey, L. Li, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Paluskievicz, J. Bromberg

    U. Maryland, Baltimore, MD

    *Purpose: Lymph node (LN) stromal laminin α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We created a Lama4 conditional knockout (KO)…
  • 2020 American Transplant Congress

    A Bioinformatics Pipeline for the Identification of Crucial Factors for Transplant Rejection Based on NGS Data

    J. Vetter1, A. Heinzel2, C. Aschauer2, R. Reindl-Schwaighofer2, K. Jelencsics2, K. Hu2, R. Oberbauer2, S. Winkler1, S. Schaller1

    1Bioinformatics Research Group, University of Applied Sciences Upper Austria, Hagenberg Campus, Hagenberg im Muehlkreis, Austria, 2Department of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria

    *Purpose: T and B cells are crucial parts of the human immune system and play an important role in transplantation. Since the mechanisms leading to…
  • 2020 American Transplant Congress

    Absolute Lymphocyte Count: Is There a “Safety Corridor?”

    G. Elhelou1, B. Lahr2, R. Razonable3

    1Medicine, Division of Infectious Diseases and Global Medicine, University of Florida, Gainesville, FL, 2Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 3Medicine, Division of Infectious Disease, Mayo Clinic, Rochester, MN

    *Purpose: Iatrogenic suppression of T cells is intended to prevent rejection after solid organ transplantation (SOT). This is complicated by opportunistic infections, most notably cytomegalovirus…
  • 2020 American Transplant Congress

    A Single-Cell Transcriptome Atlas of 15 Adult Human Organs

    Z. Guo1, S. He2, L. Wang1, Y. Liu2, J. Xu1, J. Bei2, X. He1

    1Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2The Cancer Centre of Sun Yat-Sen University, Guangzhou, China

    *Purpose: The transcriptome diversity of cell types within and across tissues is of great importance for biological function of human beings. Here we conducted a…
  • 2020 American Transplant Congress

    DEPTOR Expression within CD4+Foxp3+ T Regulatory Cells is Crucial for B Cell Activation Responses and Immunoregulation

    J. Wedel1, M. Maslyar1, S. Kong1, M. Laplante2, D. M. Briscoe1

    1Boston Children's Hospital, Boston, MA, 2Lavel University, Quebec, QC, Canada

    *Purpose: We have previously reported that the intracellular protein DEPTOR stabilizes Foxp3 expression, enhances suppressive Treg function and inhibits Treg dedifferentiation. Overexpression of DEPTOR within…
  • 2020 American Transplant Congress

    Memory T Cell-Mediated Rejection is Regulated by FcγRIIB Expression on CD8+ T Cells

    A. B. Morris, D. F. Pinelli, D. Liu, M. L. Ford

    Emory University, Atlanta, GA

    *Purpose: Donor-reactive memory T cells represent a potent immunologic barrier to long-term graft survival and tolerance induction. To identify novel pathways that regulate memory T…
  • 2020 American Transplant Congress

    Cirrhosis-Driven Immune Dysfunction is Associated with Poor Response to DEB-TACE and Waitlist Dropout in Hepatocellular Carcinoma Patients While Awaiting Liver Transplantation

    K. Nunez, T. Sandow, M. Hibino, A. Cohen, P. Thevenot

    Ochsner Health System, New Orleans, LA

    *Purpose: Hepatocellular carcinoma (HCC) recurrence after transplantation is associated with higher tumor grade on explant, failure to respond to DEB-TACE, and pretreatment lymphopenia. We prospectively…
  • 2020 American Transplant Congress

    Tonic-Signaling Chimeric Antigen Receptors Drive Exhaustion in Regulatory T Cells

    C. Lamarche1, C. Mackall2, E. Weber3, M. Levings4

    1University of British Columbia, Vancouver, BC, Canada, 2Stanford University School of Medicine, Standford, CA, 3Stanford University School of Medicine, Stanford, CA, 4Surgery, University of British Columbia and BC Children's Hospital Research Institute, Vancouver, BC, Canada

    *Purpose: Regulatory T cells (Tregs) and chimeric antigen receptor (CAR) Tregs are a promising cell therapy to prevent or treat autoimmune diseases or allograft rejection.…
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