2021 American Transplant Congress
Pre-transplant Prognostic Nutritional Index Predicts Short-term Outcomes After Liver Transplantation
Transplant Institute, Henry Ford Hospital, Detroit, MI
*Purpose: To understand the importance of pre-transplant nutritional status in optimizing liver transplant outcomes.*Methods: The prognostic nutritional index (PNI) is a serum marker of nutrition…2021 American Transplant Congress
Laminins Differentially Regulate Tolerogenic T Cell Migration and Homing to Lymph Nodes
1Surgery, UMB, Baltimore, MD, 2CVID, UMB, Baltimore, MD, 3Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) and α4 (Lama4), which are produced by lymph node (LN) stromal cells, influence CD4 T cell migration and stimulation. We hypothesized…2021 American Transplant Congress
Tip60 Inhibitors Enhance Regulatory T Cells (Treg) Induction by Promoting Acetylation of Foxp3
*Purpose: TIP60, a histone/protein acetyltransferase essential for multiple functions in the cell, is involved in Foxp3 acetylation in Treg. Acetylation protects Foxp3 from degradation, and…2021 American Transplant Congress
The Absence of T Follicular Regulatory Cells Prolongs Germinal Center Reactivity in Transplantation
*Purpose: Deleterious alloantibodies result from T follicular helper (Tfh) cell-driven germinal center (GC) reactivity. T follicular regulatory (Tfr) cells are a subset of regulatory T…2021 American Transplant Congress
Harnessing Innate Lymphoid Cells to Prevent Graft-versus Host Disease
*Purpose: Determine whether human innate lymphoid cells (ILCs) can be isolated, expanded and used in cell-based therapies to prevent Graft-versus Host Disease (GvHD) .*Methods: ILC2s…2020 American Transplant Congress
Preventing Allograft Rejection by Circrna FSCN1 Mediated Tolerogenic Dendritic Cells
Pathology, University of Western Ontario-LHSC, London, ON, Canada
*Purpose: Induction of immune tolerance is a major challenge in heart transplants. There is no robust treatment with fewer side effects for preventing chronic rejection.…2020 American Transplant Congress
Thalidomide and Dexamethasone Combinatorial Treatment Induces Tolerogenic Signals by Systemic Immunomodulation of T Cells and Dendritic Cells
*Purpose: Preventing or reducing allograft rejection is critical in organ transplantation, and the need for immune modulation rather than immune suppression has been emphasized. Many…2020 American Transplant Congress
Characterization of Laminin Alpha 4 Conditional Knockout Mice: Model for Immune Stimulation
*Purpose: Lymph node (LN) stromal laminin α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We created a Lama4 conditional knockout (KO)…2020 American Transplant Congress
A Bioinformatics Pipeline for the Identification of Crucial Factors for Transplant Rejection Based on NGS Data
*Purpose: T and B cells are crucial parts of the human immune system and play an important role in transplantation. Since the mechanisms leading to…2020 American Transplant Congress
Absolute Lymphocyte Count: Is There a “Safety Corridor?”
*Purpose: Iatrogenic suppression of T cells is intended to prevent rejection after solid organ transplantation (SOT). This is complicated by opportunistic infections, most notably cytomegalovirus…
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