Articles tagged "Lung transplantation"

2021 American Transplant Congress
Lung Transplantation After Ex-Vivo Lung Perfusion versus Static Cold Storage: A Single Institution Cost Analysis
S. E. Halpern¹, S. J. Kesseli², S. Au¹, M. K. Krischak¹, D. G. Olaso¹, H. Smith³, G. Tipton², I. Jamieson³, J. C. Haney², J. A. Klapper², M. G. Hartwig²
¹Duke University School of Medicine, Durham, NC, ²Surgery, Duke University Medical Center, Durham, NC, ³Office of Finance, Duke Transplant Center, Durham, NC
*Purpose: Ex-vivo lung perfusion (EVLP) allows for reconditioning of “marginal” lung grafts and extended lung preservation. However, EVLP is costlier than cold storage. We compared…
2021 American Transplant Congress
Outcomes of IVIG Monotherapy for Donor-Specific Antibodies After Lung Transplantation
K. Spence, S. Heeney, M. Morrison, S. A. Rega, F. D. Irene, K. B. Harrison, C. M. Shaver
Vanderbilt University Medical Center, Nashville, TN
*Purpose: De novo donor-specific antibodies (DSA) are a risk factor for antibody mediated rejection (AMR) and poor clinical outcomes after lung transplant (LT). Intravenous immune…
2021 American Transplant Congress
HTFPI.hCD47 and Adhesion Inhibition in GTKO.hCD46 Pig Lung Xenograft Injury
S. Miura¹, L. Burdorf¹, Z. Habibabady¹, A. Dandro², M. Connolly¹, S. Pratts¹, C. Phelps², W. Eyestone², D. Ayares², A. Azimzadeh¹, R. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Revivicor, Inc, Blacksburg, VA
*Purpose: We evaluate whether genetic expression of human tissue factor pathway inhibitor (TFPI, extrinsic coagulation pathway inhibitor) and human CD47 ("don’t eat me" immunoregulator), alone…
2021 American Transplant Congress
Pre-Procurement Cardiac Arrest in Lung Allograft Donors and Effects on Recipient Outcomes
T. J. Hathaway, E. C. Klipsch, D. Roe, C. Hage, M. Duncan, R. S. Mangus
Indiana University School of Medicine, Indianapolis, IN
*Purpose: This study seeks to help expand the lung transplant donor pool by demonstrating the safe use of lung allografts from donors who underwent pre-procurement…
2021 American Transplant Congress
Liver Dysfunction Following Lung Transplantation
E. J. Hyzny¹, E. G. Chan¹, J. P. Ryan¹, T. Harano¹, M. R. Morrell², P. G. Sanchez¹
¹Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: To describe the incidence and risk factors for postoperative hepatic dysfunction (POHD) following lung transplantation (LT) and long-term outcomes for these patients.*Methods: We performed…
2021 American Transplant Congress
Hepatic Ferroptosis in Cold Stress and Warm Ischemia-reperfusion: A Novel Therapeutic Target in Liver Transplantation
H. Kojima¹, H. Hirao¹, K. Kadono¹, T. Ito¹, K. J. Dery¹, S. Kageyama², K. Nakamura³, F. M. Kaldas¹, D. G. Farmer¹, J. W. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²Kyoto University, Kyoto, Japan, ³Nishi-Kobe Medical Center, Kyoto, Japan
*Purpose: Ferroptosis, a newly discovered programmed cell death platform, due to iron-dependent accumulation of lipid peroxides, has been reported to aggravate ischemia-reperfusion (IR) injury in…
2021 American Transplant Congress
Incidence and Risk Factors for Nonmelanoma Skin Cancer in Lung Transplant Recipients
G. Holdren¹, E. Lushin¹, M. Duncan², C. Hage²
¹Pharmacy, Indiana University Health, Indianapolis, IN, ²Pulmonary Critical Care, Indiana University Health, Indianapolis, IN
*Purpose: The purpose of this study is to identify the incidence of nonmelanoma skin cancer (NMSC) post lung transplantation and to examine the relationship between…
2021 American Transplant Congress
Pre Transplant Estimated Glomerular Filtration Rate and Other Predictors of Mortality and End Stage Kidney Disease After Lung Transplantation
A. Kumar¹, L. N. Bonnell², C. Thomas³
¹Internal Medicine, University of Vermont, Burlington, VT, ²Department of General Internal Medicine Research, University of Vermont, Burlington, VT, ³Internal Medicine, University of Iowa, Iowa City, IA
*Purpose: Lung transplantation is an established treatment for end stage lung disease and as survival has improved, chronic kidney disease (CKD) has become a common…
2021 American Transplant Congress
Single-cell Rna Sequencing of Latent Murine Cytomegalovirus Infected Lung Transplants
L. A. VanOsdol¹, S. Han¹, M. Kandpul², J. J. Wang¹, L. Qiu³, Z. J. Zhang¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²Department of Surgery, Northwestern University, Chicago, IL, ³School of Medicine, University of California, San Fransisco, San Fransisco, CA
*Purpose: Analyze the transcriptomics of mouse lung cells with and without latent infection of cytomegalovirus (CMV) before and after transplantation and identify key cell types…
2021 American Transplant Congress
Postoperative Tracheostomy as a Predictor of Poor Clinical Outcomes in Lung Transplantation
E. C. Klipsch, T. J. Hathaway, D. Roe, C. Hage, M. Duncan, R. S. Mangus
Indiana University School of Medicine, Indianapolis, IN
*Purpose: Tracheostomies are commonly performed postoperatively in lung transplant recipients to provide ventilation for prolonged periods, and with relatively few studies detailing these patients’ outcomes…

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