Articles tagged "Lung transplantation"

2022 American Transplant Congress
Donor-Derived IL-33 Plays a Critical Role in Lung Allograft Acceptance
Y. Guo¹, Z. Mei¹, M. Khalil¹, D. Li¹, A. Banerjee¹, A. Gelman², D. Kreisel², A. Krupnick¹
¹Department of Surgery, University of Maryland, Baltimore, Baltimore, MD, ²Washington University School of Medicine in St Louis, Saint Louis, MO
*Purpose: IL-33 is considered an alarmin secreted in response to tissue damage. While it is elaborated by the lung allograft as part of ischemia-reperfusion injury…
2022 American Transplant Congress
Lung Transplant Waitlist Outcomes for Blood Group O Candidates After the Expansion of the Primary Allocation Unit in November 2017
S. Greissman¹, M. Anderson², S. Arcasoy³, A. Dimango³, M. Gabriela³, H. Grewal³, H. Robbins³, L. Shah³, J. Costa³, F. D'Ovidio³, M. Leiva Juarez³, P. Lemaitre³, J. Sonett³, L. Benvenuto³
¹Department of Internal Medicine, New York Presbyterian, New York, NY, ²University of Pennsylvania, Philadelphia, PA, ³Columbia University, New York, NY
*Purpose: Blood group O is associated with decreased lung transplant rates. Occasionally, blood group donor O lungs are allocated to non-blood group O recipients. Since…
2022 American Transplant Congress
Immunomodulation in Lung Transplant May Facilitate Transformation of Usual Interstitial Pneumonia Into Pleuroparenchymal Fibroelastosis
Q. Cai¹, K. Batra², J. R. Torrealba¹
¹Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, ²Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: Pleuroparenchymal fibroelastosis (PPFE) is a rare but distinctive manifestation of interstitial lung disease (ILD) characterized by a highly elastotic pattern of lung fibrosis. Its…
2022 American Transplant Congress
B and Plasma Cell Populations Drive Chronic Rejection After Lung Transplantation
M. Bueno¹, N. F. Smirnova², K. Riemondy³, P. Suresh¹, M. Brown¹, X. Wang¹, S. Collins⁴, J. Sembrat¹, M. Koenigshoff¹, M. Snyder¹, J. McDyer¹, O. Eickelberg¹
¹Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, ²I2MC, INSERM UMR1297, Toulouse, France, ³Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, ⁴Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO
*Purpose: Chronic lung allograft dysfunction (CLAD) remains the major determinant of morbidity and mortality post-lung transplantation (LTx). Bronchiolitis obliterans syndrome (BOS) is the most prevalent…
2022 American Transplant Congress
Impact Of Antifungal Prophylaxis Discontinuation On Immunosuppression In Lung Transplant Recipients
R. Huntsman, K. Neuhaus
Pharmacy, Cleveland Clinic, Cleveland, OH
*Purpose: The purpose of this study is to characterize the impact of antifungal discontinuation on immunosuppressant levels and incidence of acute rejection and fungal infections…
2022 American Transplant Congress
Differing Gene Expression Profiles and Signaling Pathways Observed Between Alloreactive and Tolerant T Cells in a Recipient Following Bilateral Orthotopic Lung Transplant (BOLT) and Bone Marrow Transplant (BMT) from the Same Cadaveric UNOS Donor
P. Szabolcs, E. Garchar, D. Rajasundaram, X. Chen
UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA
*Purpose: Primary immunodeficiency (PID) patients may develop pulmonary complications, and most are ineligible for either BOLT or BMT due to futility. A prospective trial in…
2022 American Transplant Congress
Emphysematous Cystitis in a Lung Transplant Recipient with BK Viremia
D. Razia, J. Klein, H. Mohamed, A. Arjuna
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: Emphysematous cystitis (EC) is a rare urinary tract infection from E. coli or K. pneumoniae in diabetics or immunocompromised individuals, resulting in sepsis and…
2022 American Transplant Congress
Mitochondrial Dysfunction and Alloimmunity in Chronic Lung Transplant Rejection
M. Cano¹, D. Zhou², C. Chen³, K. Pugh⁴, D. Byers¹, D. Kreisel⁵, R. Hachem¹, A. Gelman⁵
¹Pulmonary and Critical Care, Washington University, Saint Louis, MO, ²Surgery, Washington University, Saint Louis, MO, ³Pulmonary and Critical Care, UT Southwestern Medical Center, Dallas, TX, ⁴Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, ⁵Surgery and Immunology and Pathology, Washington University, Saint Louis, MO
*Purpose: Bronchiolitis obliterans syndrome (BOS) remains a major cause of death after lung transplantation. Unfortunately, we lack effective treatments for BOS as the mechanisms by…
2021 American Transplant Congress
Pregnancy Outcomes in 39 Lung Transplant Recipients
S. Constantinescu¹, L. A. Coscia², A. Yusuf², S. Rao³, M. J. Moritz⁴
¹Lewis Katz School of Medicine at Temple University, Philadelphia, PA, ²Transplant Pregnancy Registry International, Philadelphia, PA, ³University of Virginia Heath System, Charlottesville, VA, ⁴Lehigh Valley Health Network, Allentown, PA
*Purpose: The purpose of this study is to describe 52 pregnancies in 39 lung transplant recipients reporting to the Transplant Pregnancy Registry International (TPRI) from…
2021 American Transplant Congress
Prevalence of Hepatitis E Virus Infection in Solid Organ Transplant Recipients: A Systematic Review and Meta-analysis
P. Hansrivijit¹, A. Trongtorsak², B. Boonpheng³, C. Thongprayoon⁴, W. Cheungpasitporn⁴
¹Department of Internal Medicine, UPMC Pinnacle, Harrisburg, PA, ²Department of Internal Medicine, Amita Health Saint Francis Hospital, Evanston, IL, ³Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, CA, ⁴Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN
*Purpose: Hepatitis E virus (HEV) infection is an underdiagnosed disease due to the use of serological assays with low sensitivity. Although most patients with HEV…

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