2022 American Transplant Congress
Clinical Impact of a Modified Lung Allocation Score That Mitigates Selection Bias
*Purpose: The U.S. lung allocation system uses the Lung Allocation Score (LAS) to prioritize lung transplant candidates. Selection bias, induced by dependent censoring of waitlisted…2022 American Transplant Congress
Direct Central Ambulatory Venoarterial Extracorporeal Membrane Oxygenation and Double Lung Transplantation without Graft Reduction with Extreme Mediastinal Shift
*Purpose: Double Lung transplantation in the presence of extreme mediastinal shift can be technically challenging due to donor sizing and recipient factors.*Methods: We present the…2022 American Transplant Congress
Lung Transplant Recipients with Sars-cov2 Infection and Bnt162b2 Vaccination Induce Circulating Exosomes with Spike Protein S2 Capable of Inducing Immune Responses to Sars0-cov2 in Mice
1St. Joseph’s Hospital and Medical Center, Phoenix, AZ, 2Yale School of Medicine, New Haven, CT
*Purpose: Exosomes are small vesicles which are released by cells into body fluids. We have demonstrated the presence of circulating exosomes with viral antigens in…2022 American Transplant Congress
De Novo Donor-Specific Antibody Development with Mycophenolate versus Azathioprine in Lung Transplant Recipients
*Purpose: The effect of mycophenolate mofetil (MMF) or azathioprine (AZA) immunosuppression (ISN) regimens on de novo donor specific antibody (DSA) formation in lung transplant recipients…2022 American Transplant Congress
The Addition of Bortezomib to a Rituximab Based Antibody Mediated Rejection Treatment Protocol in Lung Transplant
Loyola University Medical Center, Maywood, IL
*Purpose: To evaluate the impact of antibody mediated rejection (AMR) treatment with rituximab combined with bortezomib vs. rituximab alone on patient survival, graft survival, and…2022 American Transplant Congress
Lung Transplantation For Covid-19: An International Registry
*Purpose: SARS-CoV-2 can result in a range of infections from asymptomatic disease to progressive COVID-19 and death. In some patients with COVID-19 Lung Disease (C19LD),…2022 American Transplant Congress
Inhalation Alone versus Inhalation Plus Intravenous Colistin for Multidrug-Resistant Gram-Negative Bacterial Infection After Lung Transplantation
*Purpose: After lung transplantation, patients are exposed to the risk of various infections accounting for morbidity and mortality. Multidrug-resistant gram-negative (MDR-GN) bacteria are emerging pathogen.…2022 American Transplant Congress
Surveillance with Allosure for Allograft Rejection and Infection in Lung Transplant
*Purpose: Measurement of plasma donor-derived cell-free DNA (dd-cfDNA; AlloSure, CareDx) has been shown to be a useful non-invasive diagnostic test for injury and infection after…2022 American Transplant Congress
Perioperative Cardiovascular Outcomes of Pre-Transplant ECMO in Recipients of Lung Transplant
*Purpose: Use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplant (BTT) has increased over time. While similar one-year and overall survival has…2022 American Transplant Congress
Variability In Plasma Donor-derived Cell-free DNA Levels With CLAD More Than 5-years After Lung Transplantation: Pilot Data
1Department of Medicine, University of Texas, San Antonio, San Antonio, TX, 2Natera, Inc., Ausin, TX
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been clinically validated for detection of acute rejection (AR) in lung transplant (LT) although studies have typically focused on…
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