ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Lung transplantation"

  • 2015 American Transplant Congress

    Broader Geographic Sharing of Adolescent Lung Donors Improves Allocation Efficiency

    W. Tsuang,1 J. Pyke,2 M. Skeans,2 K. Chan,4 T. Wozniak,3 A. Israni,2 M. Hertz,4 B. Kasiske,2 M. Valapour,1 J. Snyder.2

    1Cleveland Clinic, Cleveland, OH; 2SRTR, MMRF, Minneapolis, MN; 3IN University, Indianapolis, IN; 4University of MI, Ann Arbor, MI; 5University of MN, Minneapolis, MN.

    Allocating pediatric donor lungs to pediatric lung transplant (TXP) candidates results in better graft function. However, 87% of adolescent (ADL) donor lungs are allocated to…
  • 2015 American Transplant Congress

    High Atherosclerotic Burden in Pediatric Lung Transplant Recipients

    A. Melk,1 D. Thurn-Valsassina,1 N. Schwerk,2 F. Brinkmann,2 C. Mueller.2

    1Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany; 2Department of Pediatric Pneumology and Neonatology, Hannover Medical School, Hannover, Germany.

    Purpose: Pediatric lung transplant patients have been reported to have an increased incidence of hypertension. This incidence might be caused by the treatment with calcineurin…
  • 2015 American Transplant Congress

    A New Diagnostic Tool for Antibody Mediated Rejection in Heart and Lung Transplantation: Intragraft Donor Specific Anti-HLA Antibodies Detection

    J. Olagne,1,2,3 A. Parissiadis,2 N. Froelich,2 S. Caillard,1 M.-P. Chenard,3 E. Epailly,4 H. Kremer,4 T. Degot,5 S. Hirschi,5 R. Kessler,5 B. Moulin.1

    1Service de Néphrologie - Transplantation, Centre Hospitalier Universitaire, Strasbourg, France; 2Laboratoire d'Histocompatibilité, Etablissement Français du Sang, Strasbourg, Alsace, France; 3Département de Pathologie, Centre Hospitalier Universitaire, Strasbourg, France; 4Service de Cardiologie, Centre Hospitalier Universitaire, Strasbourg, France; 5Service de Pneumologie, Centre Hospitalier Universitaire, Strasbourg, France.

    INTRODUCTION: Antibody mediated rejection (AMR) is one of the causes of dysfunction and graft loss. The limited histological features, with a weak sensibility of c4d,…
  • 2015 American Transplant Congress

    Lung Biopsy Findings in Pediatric Lung Transplant Patients With Restrictive Physiology

    J. Blatter,1 F. White,2 A. Faro,1 P. Michelson,1 U. Boston,3 P. Eghtesady,3 S. Sweet.1

    1Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO; 2Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO; 3Department of Cardiothoracic Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO.

    Background: Long-term survival in pediatric lung transplantation is limited by bronchiolitis obliterans (BO), but varieties of chronic lung allograft dysfunction (CLAD) are poorly understood. Restrictive…
  • 2015 American Transplant Congress

    Post Transplant De Novo Donor Specific Antibodies Correlate With the Development of Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation

    E. Melicoff, J. Maddox, M. Ebenbichler, J. Heinle, D. McKenzie, P. Jindra, G. Mallory, R. Kerman.

    Texas Children's Hospital, Houston, TX; Baylor College of Medicine, Houston, TX.

    HLA donor specific antibodies (DSA) have been associated with poor allograft survival following adult solid organ transplantation (Tx). However, there is little evidence implicating post-Tx…
  • 2015 American Transplant Congress

    Epidemiologic Change in Pulmonary Hypertension Patients Referred for Lung Transplantation Post Lung Allocation Score Implementation

    R. Loyaga-Rendon,1 B. Shelton,1 R. Reed,1 J. Tallaj,1 E. Diaz-Guzman,1 G. Heresi,2 J. Locke.1

    1Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL; 2Pulmonary Medicine, Cleveland Clinic Foundation, Cleveland, OH.

    Introduction: The lung allocation score (LAS) was designed and implemented in May 2005 to account for various measures of a candidate's health in an attempt…
  • 2015 American Transplant Congress

    Th17 Mediates Inflammatory Responses After Lung Transplantation

    J. Xu,1 L. Wang,1 Q. Chen,2 S. Xia,1 X. Li,1 H. Li,2 Y. Ding.1,3

    1Department of Immunology, Capital Medical University, Beijing, China; 2Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; 3Department of Respiratory Diseases, Capital Medical University, Beijing, China.

    Background: Long-term outcomes after lung transplantation are markedly worse than for other organs. The mechanisms that determine lung transplant rejection are not clear. The role…
  • 2015 American Transplant Congress

    Long Term Survival After Single Versus Double Lung Transplantation in Patients With Pulmonary Fibrosis in the Modern Era of the Lung Allocation Score

    V. Ambur, S. Jayarajan, S. Taghavi, S. Kadakia, C. Lewis, Y. Furuya, A. Shiose, L. Kaiser, G. Wheatley, T. Guy, Y. Toyoda.

    Surgery, Temple University Hospital, Philadelphia, PA.

    Objectives: To examine long-term survival in patients with idiopathic pulmonary fibrosis (IPF) after the implementation of the lung allocation score (LAS) in single lung transplantation…
  • 2015 American Transplant Congress

    Epidemiology and Outcomes of Non Tuberculous Mycobacterial (NTM) Infections in Solid Organ Transplant (SOT) Recipients

    I. George, C. Santos, M. Olsen, T. Bailey.

    Infectious Diseases, Washington University School of Medicine, St. Louis, MO.

    Background: NTM are uncommon causes of infection in SOT recipients but may cause significant morbidity and mortality.Methods: A retrospective cohort of all patients who underwent…
  • 2015 American Transplant Congress

    The Preservation Technique Modulates the Immunological Milieu in Lung Transplantation and Affects the Pro-/ Anti-Inflammatory Balance

    M. Seyda,1 B. Wiegmann,3 B. Mueller,2 C. Neudoerfl,1 A. Akhdar,1 K. Daemen,1 A. Haverich,3,4 G. Warnecke,3,4 C. Falk.3,5

    1Inst. of Transplant Immunology, IFB-Tx, Hanover Medical School, Hanover, Germany; 2MorphoSys, Munich, Germany; 3Cardiothoracic, Transplantation and Vascular Surgery, Hanover Medical School, Hanover, Germany; 4German Center for Lung Research, Gießen, Germany; 5German Center for Infection Research, Braunschweig, Germany.

    Little is known regarding the influence of different preservation techniques (i.e. cold static storage with Perfadex® or Celsior® solution) on the immunological milieu, especially lung-resident…
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