Articles tagged "Lung transplantation"

2015 American Transplant Congress
Acute Kidney Injury After Lung Transplantation – Incidence, Risk Factors and Mechanisms
F. Gueler,¹ G. Warnecke,⁵ M. Peperhove,² M.-S. Jang,¹ C. Schroeder,³ S. Tewes,² B. Wiese,⁶ C. Fegbeutel,⁵ R. Lichtinghagen,⁷ B. Jüttner,⁸ F. Wacker,² D. Hartung,² B. Akerstrom,⁴ M. Gram,⁴ H. Haller,¹ A. Haverich,⁹ K. Hueper.²
¹Nephrology, Hannover Medical School, Hannover, Germany; ²Radiology, Hannover Medical School, Hannover, Germany; ³Proteomics, German Research Cancer Center, Heidelberg, Germany; ⁴Physiology, Lund University, Lund, Sweden; ⁵Thoracic and Cardiac Surgery, Hannover Medical School, Hannover, Germany; ⁶Medical Statistics, Hannover Medical School, Hannover, Germany; ⁷Laboratory Medicine, Hannover Medical School, Hannover, Germany; ⁸Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany; ⁹Cardiothoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Background: Acute kidney injury (AKI) is a frequent and severe complication after solid organ transplantation. In a retrospective analysis and afterwards in a prospective clinical…
2015 American Transplant Congress
Lung Transplantation from Donors With Kidney Disease
A. Ganapathi, B. Gulack, A. Castleberry, R. Davis, L. Snyder, M. Hartwig.
Duke University Medical Center, Durham, NC.
Background:Various donor characteristics are associated with decreased survival following single (SLT) or bilateral (BLT) lung transplantation. No current studies exist regarding use of lungs from…
2015 American Transplant Congress
The Impact of High-Risk Lung Donors on the Survival of Lung Recipients With Interstitial Pulmonary Fibrosis
P. Sanchez,¹ M. Mulligan,¹ C. Evans,¹ I. Timofte,² J. Kim,² K. Rajagopal,¹ A. Iacono,² J. Gammie,¹ R. Pierson III,¹ B. Griffith,¹ S. Pham.¹
¹Cardiac Surgery, University of Maryland School of Medicine, Baltimore, MD; ²Medicine, University of Maryland School of Medicine, Baltimore, MD.
Matching donors and recipients is largely based on experience. With the implementation of the LAS, IPF candidates have the highest provability of being transplanted after…
2015 American Transplant Congress
Pre-Existing Coronary Artery Disease in Lung Transplantat Recipients: Does It Impact Outcomes?
S. Khandhar,¹ L. Tefera,² E. Volz,² F. Selzer,³ R. Kormos,² C. Bermudez.²
¹Heart and Vascular Institute at Penn-Presbyterian Medical Center, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA; ²Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA; ³Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Womens Hospital, Boston, MA.
INTRODUCTION:In patients undergoing lung transplantation (LTx), the impact of pre-existing coronary artery disease (CAD) on long-term outcomes is not well understood. This study examines the…
2015 American Transplant Congress
Broader Geographic Sharing of Adolescent Lung Donors Improves Allocation Efficiency
W. Tsuang,¹ J. Pyke,² M. Skeans,² K. Chan,⁴ T. Wozniak,³ A. Israni,² M. Hertz,⁴ B. Kasiske,² M. Valapour,¹ J. Snyder.²
¹Cleveland Clinic, Cleveland, OH; ²SRTR, MMRF, Minneapolis, MN; ³IN University, Indianapolis, IN; ⁴University of MI, Ann Arbor, MI; ⁵University of MN, Minneapolis, MN.
Allocating pediatric donor lungs to pediatric lung transplant (TXP) candidates results in better graft function. However, 87% of adolescent (ADL) donor lungs are allocated to…
2015 American Transplant Congress
High Atherosclerotic Burden in Pediatric Lung Transplant Recipients
A. Melk,¹ D. Thurn-Valsassina,¹ N. Schwerk,² F. Brinkmann,² C. Mueller.²
¹Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany; ²Department of Pediatric Pneumology and Neonatology, Hannover Medical School, Hannover, Germany.
Purpose: Pediatric lung transplant patients have been reported to have an increased incidence of hypertension. This incidence might be caused by the treatment with calcineurin…
2015 American Transplant Congress
A New Diagnostic Tool for Antibody Mediated Rejection in Heart and Lung Transplantation: Intragraft Donor Specific Anti-HLA Antibodies Detection
J. Olagne,^1,2,3 A. Parissiadis,² N. Froelich,² S. Caillard,¹ M.-P. Chenard,³ E. Epailly,⁴ H. Kremer,⁴ T. Degot,⁵ S. Hirschi,⁵ R. Kessler,⁵ B. Moulin.¹
¹Service de Néphrologie - Transplantation, Centre Hospitalier Universitaire, Strasbourg, France; ²Laboratoire d'Histocompatibilité, Etablissement Français du Sang, Strasbourg, Alsace, France; ³Département de Pathologie, Centre Hospitalier Universitaire, Strasbourg, France; ⁴Service de Cardiologie, Centre Hospitalier Universitaire, Strasbourg, France; ⁵Service de Pneumologie, Centre Hospitalier Universitaire, Strasbourg, France.
INTRODUCTION: Antibody mediated rejection (AMR) is one of the causes of dysfunction and graft loss. The limited histological features, with a weak sensibility of c4d,…
2015 American Transplant Congress
Lung Biopsy Findings in Pediatric Lung Transplant Patients With Restrictive Physiology
J. Blatter,¹ F. White,² A. Faro,¹ P. Michelson,¹ U. Boston,³ P. Eghtesady,³ S. Sweet.¹
¹Department of Pediatrics, Washington University School of Medicine in St. Louis, St. Louis, MO; ²Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO; ³Department of Cardiothoracic Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO.
Background: Long-term survival in pediatric lung transplantation is limited by bronchiolitis obliterans (BO), but varieties of chronic lung allograft dysfunction (CLAD) are poorly understood. Restrictive…
2015 American Transplant Congress
Post Transplant De Novo Donor Specific Antibodies Correlate With the Development of Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation
E. Melicoff, J. Maddox, M. Ebenbichler, J. Heinle, D. McKenzie, P. Jindra, G. Mallory, R. Kerman.
Texas Children's Hospital, Houston, TX; Baylor College of Medicine, Houston, TX.
HLA donor specific antibodies (DSA) have been associated with poor allograft survival following adult solid organ transplantation (Tx). However, there is little evidence implicating post-Tx…
2015 American Transplant Congress
Epidemiologic Change in Pulmonary Hypertension Patients Referred for Lung Transplantation Post Lung Allocation Score Implementation
R. Loyaga-Rendon,¹ B. Shelton,¹ R. Reed,¹ J. Tallaj,¹ E. Diaz-Guzman,¹ G. Heresi,² J. Locke.¹
¹Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL; ²Pulmonary Medicine, Cleveland Clinic Foundation, Cleveland, OH.
Introduction: The lung allocation score (LAS) was designed and implemented in May 2005 to account for various measures of a candidate's health in an attempt…