2015 American Transplant Congress
Marrow Mesenchymal Stem Cells Attenuate Immune Rejection in Murine Lung Allograft
Objectives:The inherent immunosuppressive properties and low immunogenicity of mesenchymal stems cells (MSCs) suggested their therapeutic potential in transplantation. In this study we investigated if systematic…2015 American Transplant Congress
Bortezomib-Based Multi-Modality Protocol for Donor-Specific Antibody Treatment in Lung Transplant Recipients
Duke University Hospital, Durham, NC.
Background Donor specific antibodies (DSAs) after lung transplant have been implicated in the development of chronic lung allograft dysfunction and mortality. The ideal treatment strategy…2015 American Transplant Congress
Lifor Organ Preservation Solution Protects Pulmonary Microvasculature in a Rat Model of Ex Vivo Lung Perfusion and Transplantation
A. Ex Vivo Lung Perfusion (EVLP) has emerged as an innovative method for lung preservation. Microvascular dysfunction and breakdown of endothelial barrier during EVLP are…2015 American Transplant Congress
Operating Room Extubation After Bilateral Lung Transplantation in Cystic Fibrosis Patients: A Single Center Experience
Short-acting anesthetic drugs, thoracic epidural analgesia and a strict ventilation weaning protocol could permit extubation in the operating room (OR) (1). Aims of this study…2015 American Transplant Congress
C1q Reactivity and IgG Subtypes After HLA Antibody Removal Therapy With Carfilzomib in Thoracic Transplant Recipients
Univ of Pittsburgh, Pittsburgh.
Conventional therapies for antibody removal consisting of plasma exchange with IVIG and Rituximab are partially effective in desensitization protocols and for treatment of antibody mediated…2015 American Transplant Congress
Does Pulmonary Rehabilitation Impact Frailty?
Purpose: Frailty is an emerging risk factor for morbidity and mortality in advanced lung disease and lung transplantation. Interventions to reduce frailty in this population…2015 American Transplant Congress
Donor Microbiota and Its Contribution for the Development of Primary Graft Dysfunction Following Human Lung Transplantation
Background: The microbiome of the donor lung will be imported to the recipient, and its role in allograft immunity remains speculative. The aims of this…2015 American Transplant Congress
Donor Lung Preservation With the Organ Care System® Promotes a Tissue Protective and Anti-Inflammatory Response During Transplantation
ObjectivesWithin INSPIRE trial standard cold storage (SOC) is compared to normothermic, ventilated donor lung preservation (Organ-Care-System®, OCS). As lung preservation may influence immune mediators (IM),…2015 American Transplant Congress
Respiratory Infections Following Lung Transplantation Leads to De Novo Development of Antibodies to Both Donor HLA and Lung Associated Self-Antigens and Increases the Risk for Bronchiolitis Obliterans Syndrome
Background: It is accepted that lower respiratory tract infections (LRI) post lung transplantation (LTx) are a risk factor for the development of Bronchiolitis Obliterans Syndrome…2015 American Transplant Congress
Ex Vivo Lung Perfusion: Revisit to the Optimal Oxygenation Circulating Lungs for Graft Preservation
Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.
AimAccumulating evidence supports increasing the role of ex vivo lung perfusion (EVLP). However, there are evidenced limitations as well as the adverse effects of current…
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