2017 American Transplant Congress
Improving Vaccination Rates for Lung Transplant Candidates.
In 2015, transplant pharmacists at the University of Chicago identified an opportunity to improve vaccination rates for transplant candidates. On 10/1/15, a pharmacist-led program was…2017 American Transplant Congress
Abrogating MyD88 Signaling in Donor Lung Resident Hematopoietic Cells Promotes Cell Based Tolerance Induction in Lung Allografts in Mice.
Objectives: MyD88 signaling plays an important role in allograft rejection and tolerance induction. This study is designed to determine the cellular base of MyD88 expression…2017 American Transplant Congress
Risk of Venous Thromboembolism After Lung Transplant.
PurposeVenous thromboembolism (VTE) is a significant cause of morbidity and mortality following lung transplantation. The purpose of this study was to describe the incidence of…2017 American Transplant Congress
Modifiable Deceased Organ Donor Critical Care Parameters Impact Donor Lung Utilization.
1VA Portland Health Care System, Portland; 2Massachusetts General Hospital, Boston
Objective: There is a shortage of organs available for transplantation, yet only 25% of lungs from donors after neurologic determination of death (DNDDs) are currently…2017 American Transplant Congress
Xenogeneic Lung Transplantation: Identifying Transgenes and Supportive Drug Treatments to Achieve Long-Term Survival.
1Surgery, University of Maryland, Baltimore, MD; 2Revivicor, Inc., Blacksburg, VA
Purpose: Recent progress in genetic engineering has facilitated generation of pigs expressing various multi-transgene and knock-out combinations. Which transgenes and what targeted drug treatments are…2017 American Transplant Congress
TRPV4 Channels Mediate Pulmonary Edema and Inflammation During Ischemia-Reperfusion Injury.
University of Virginia, Charlottesville, VA
Rationale: Lung ischemia-reperfusion (IR) injury remains a major challenge in post-transplant patients. Transient receptor potential vanilloid 4 (TRPV4) cation channels mediate cellular calcium influx, and…2017 American Transplant Congress
Coagulation Pathway Perturbations Associated with Pig-to-Baboon Lung Xenotransplantation.
Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD
Aim Dysregulation of coagulation is associated with graft failure in multiple xenotransplantation models. This study describes thromboelastographic profiles in baboon recipients of a genetically engineered…2017 American Transplant Congress
Donor-Derived Nonclassical Monocytes Produce MIP-2 to Recruit Recipient Neutrophils and Cause Ischemia Reperfusion Injury After Lung Transplant.
1Northwestern University, Chicago; 2Washington University, St Louis
Purpose: Primary graft dysfunction (PGD), the primary cause of early mortality after lung transplant, is mediated by neutrophils. However, neutrophil depletion may not be clinically…2017 American Transplant Congress
The Role of Anti-Neu5Gc IgM in Xenograft Antibody Mediated Rejection.
Background:Acute antibody mediated rejection due to preformed antibodies present in human serum remains a hurdle to successful xenotransplantation. Here, we measured anti-Neu5Gc-IgM antibody titers in…2017 American Transplant Congress
Immune Monitoring-Guided Treatment of a Pediatric Patient with Sequential GvHD, Acute Rejection and CMV Infection Following Lung Transplantation.
Background: A 17 year old patient with cystic fibrosis (HLA-A11+, CMV-) underwent bilateral sequential lung transplantation (donor: HLA-A32+, CMV+). Immunosuppression (IS) consisted of Tacrolimus, MMF…
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