Articles tagged "Lung transplantation"

2019 American Transplant Congress
Recipient Monocytes Activated by Endobronchial Toll-Like Receptor 2 Agonist Prevent Tolerance Induction after Lung Transplantation
S. Tanaka¹, J. M. Gauthier¹, Y. Terada¹, T. Takahashi¹, W. Li¹, R. Higashikubo¹, A. Y. Tong¹, V. Puri¹, A. S. Krupnick², A. E. Gelman¹, D. Kreisel¹
¹Department of Surgery, Washington University in St. Louis, St. Louis, MO, ²Department of Surgery, The University of Virginia, Charlottesville, VA
*Purpose: Extended criteria lung donors are being increasingly utilized, raising the possibility of transplanting lungs with a pre-existing pneumonia; how donor pneumonia alters alloimmune responses,…
2019 American Transplant Congress
Assessment Of Glomerular Filtration Rate Among Lung Transplant Candidates
S. Akkina¹, S. Hou², D. Jain Arwindekar², A. Desai²
¹Loyola University Medical Center, Maywood, IL, ²Medicine, Loyola University Medical Center, Maywood, IL
*Purpose: Assessment of kidney function in lung transplant candidates is difficult due to cachexia prior to transplant. Measured glomerular filtration rate (GFR) studies are useful…
2019 American Transplant Congress
Listing Practices and Graft Utilization Lag behind Supply of Hepatitis C Positive Deceased Donors for Liver and Kidney Transplant
C. E. Kling¹, J. D. Perkins², S. W. Biggins³, C. Johnson⁴, A. P. Limaye⁵, L. Sibulesky¹
¹Division of Transplant Surgery, University of Washington Medical Center, Seattle, WA, ²Division of Transplant Surgery and Clinical and Bio-Analytics Transplant Laboratory, University of Washington Medical Center, Seattle, WA, ³Divisions of Gastroenterology and Hepatology and Center for Liver Investigation Fostering DiscovEry, University of Washington Medical Center, Seattle, WA, ⁴Division of Nephrology, University of Washington Medical Center, Seattle, WA, ⁵Division of Infectious Disease, University of Washington Medical Center, Seattle, WA
*Purpose: The opioid epidemic resulted in increasing incidence of hepatitis C (HCV) in the general population and more deceased organ donors with HCV in the…
2019 American Transplant Congress
Circulating Exosomes Isolated from Human Lung Transplant Recipients with Respiratory Viral Infections Contain Nucleic Acids Specific to Virus and Can Lead to Activation of Stress Proteins
S. Bansal, R. Bremner, M. Smith, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Exosomes are membrane vesicles released by cells into body fluids. Our laboratory demonstrated the presence of circulating exosomes with lung self-antigens (SAgs), Collagen V…
2019 American Transplant Congress
A Randomized Pilot Trial of Home-Based Physical Activity Plus Dietary Intervention to Improve Physical Function in Patients with Advanced Liver Disease
H. Chen¹, A. A. Ferrando², M. G. White², M. Pauly², T. Bartter², M. A. Dunn¹, W. R. Kim³, A. Duarte-Rojo¹
¹T.E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, ²University of Arkansas for Medical Sciences, Little Rock, AR, ³Stanford University, Palo Alto, CA
*Purpose: Deconditioning and frailty are prevalent among liver transplant (LTx) candidates and prehabilitation programs have been proposed in order to improve clinical outcomes. However, few…
2019 American Transplant Congress
The Molecular Features of Chronic Lung Allograft Dysfunction (CLAD) in Transbronchial and Endobronchial Mucosa Biopsies
M. D. Parkes¹, K. M. Halloran¹, J. Chang², P. F. Halloran and the INTERLUNG study group¹
¹University of Alberta, Edmonton, AB, Canada, ²ATAGC, University of Alberta, Edmonton, AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD), the major long-term problem in lung transplantation, requires new strategies for prevention and management. However, CLAD is infrequently diagnosed…
2019 American Transplant Congress
Caregiving in Thoracic Transplantation–A SR/MA
A. A. Rmilah, J. Lau, R. Mendpara, P. Erwin, C. C. Kennedy
Mayo Clinic, Rochester, MN
*Purpose: Caregivers are required for heart and lung transplantation, however, little emphasis is placed on the pre-transplant caregiving experience. Our objective was to perform a…
2019 American Transplant Congress
Bronchoalveolar Lavage Biomarkers Predict Lung Transplant Survival
A. Zarinsefat¹, J. Y. Yang², R. Sarwal¹, J. Liberto¹, D. Watson³, S. Verleden⁴, M. Sarwal¹
¹UC San Francisco, San Francisco, CA, ²Johns Hopkin, Baltimore, MD, ³Kit Bio, Los Altos, CA, ⁴KU Leuven, Leuven, Belgium
*Purpose: In lung transplants (LTx), chronic rejection remains a major cause of morbidity and mortality following transplantation, mainly from chronic lung allograft dysfunction (CLAD). Two…
2019 American Transplant Congress
Syphilis Transmission in Solid Organ Transplantation
M. Morrison, M. Hurtik, G. M. Lyon, S. Pouch
Emory University Hospital, Atlanta, GA
*Purpose: Syphilis is a sexually transmitted infection that affects people worldwide. While transmission generally occurs via sexual contact, other modes of transmission are possible, including…
2019 American Transplant Congress
Azole Use and Fungal Pathogens in Cystic Fibrosis versus Non-Cystic Fibrosis Lung Transplant Recipients
F. J. Marco Canosa¹, K. Brizendine², H. Hassouna³
¹Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH, ²Infectious Disease, Cleveland Clinic Foundation, Cleveland, OH, ³Infectious Disease, Spectrum Health Infectious Disease, Grand Rapids, MI
*Purpose: Cystic fibrosis (CF) patients exhibit unique pharmacokinetic principles. Azole antifungals show marked inter- and intra-patient variability. We aimed to improve itraconazole (ITR) use and…