Articles tagged "Lung transplantation"

2019 American Transplant Congress
Impact Of Inhaled Vasodilator Therapy On Early Morbidity And Mortality After Lung Transplant
M. Tomeczkowicz¹, A. Wexler¹, M. Patel², J. Fernandez-Castillo², J. Rusniak¹, E. Mancl³, S. Quddus²
¹Department of Pharmacy, Loyola University Medical Center, Maywood, IL, ²Division of Pulmonary and Critical Care, Loyola University Medical Center, Maywood, IL, ³Loyola University Medical Center, Maywood, IL
*Purpose: Within the first 72 hours of lung transplant, recipients may develop primary graft dysfunction (PGD). This complication is associated with acute and chronic rejection,…
2019 American Transplant Congress
Examination of a Novel Immunoregulatory Marker in Kidney and Lung Transplant Recipients
A. D. Desai¹, G. J. Kavalam², A. Chandraker², S. Tripathi²
¹1Harvard Summer Research Program for Kidney Medicine, Harvard Medical School,, Boston, MA, ²Schuster Family Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
*Purpose: The T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is a co-inhibitory receptor mainly expressed on T cells and NK cells. TIGIT has…
2019 American Transplant Congress
The Frequency of Tissue-Resident Donor T and NK Cells in Peripheral Blood after Lung Transplantation is Modulated by Normothermic Ex Vivo Lung Perfusion
C. S. Falk¹, B. Wiegmann², A. Hitz¹, R. Bellmas-Sanz¹, K. Bläsing¹, F. Ius², C. Kühn², M. Avsar², I. Tudorache², J. Kühne¹, F. Wandrer¹, A. Haverich², G. Warnecke²
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: The appearance of passenger donor lymphocytes in recipient blood after double lung transplantation has been described decades ago. However, neither their early kinetics, nor…
2019 American Transplant Congress
Intact Lymphatics Are Essential for Costimulation Blockade-Induced Lung Allograft Survival
L. Wang¹, H. Reed², R. Han¹, M. Kahn², W. W. Hancock¹
¹Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA
*Purpose: Blocking lymphangiogenesis is thought to diminish immune responses to donor tissues. However, lung transplantation (Tx), which involves airway and vascular but not lymphatic anastomoses,…
2019 American Transplant Congress
Outcomes for Lung Transplantation Recipients with Non-Alcoholic Fatty Liver Disease
A. J. Trindade¹, P. Burkett¹, S. El-Chemaly¹, N. Hashemi², T. Thaniyavarn¹, H. R. Mallidi³, H. J. Goldberg¹
¹Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ²Gastroenterology and Hepatology, Brigham and Women's Hospital, Boston, MA, ³Division of Thoracic and Cardiovascular Surgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Non-alcoholic Fatty Liver Disease (NAFLD) afflicts ~20-40% people in the western world and is a risk factor for comorbidities prevalent in the lung transplant…
2019 American Transplant Congress
Waitlisted for Lung Transplant and the Role of Patient Travel Distance: A National Cohort Study
W. Tsuang, S. Arrigain, R. Lopez, M. Snair, K. McCurry, M. Budev, J. Schold
Cleveland Clinic, Cleveland, OH
*Purpose: Among patients waitlisted at the 75 lung transplant centers in the United States, the role of travel distance on waitlist outcomes is unknown. We…
2019 American Transplant Congress
Progress Using Genetically Engineered Pigs for Lung Xenotransplantation
L. Burdorf¹, C. Laird², S. Sendil², T. Zhang², D. Parsell², I. Tatarov², B. Cerel¹, Z. Abady¹, S. Pratts¹, C. J. Phelps³, D. L. Ayares³, A. M. Azimzadeh¹, R. N. Pierson III¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Surgery, University of MD, Baltimore, MD, ³Revivicor, Blacksburg, VA
*Purpose: CRISPR/Cas9 gene editing techniques facilitate generation of pigs with multiple genetic modifications. We report results associated with multiple mechanistically targeted gene knock-outs and transgenes,…
2019 American Transplant Congress
Differential Impact of Donor and Recipient Age on Post-Lung Transplantation Outcomes
K. Patel¹, C. Li¹, C. Wallace¹, J. Kilkenny¹, D. P. Allen¹, S. Nadig¹, M. Goddard², C. Krieg¹, C. Atkinson¹
¹Surgery, Medical University of South Carolina, Charleston, SC, ²Pathology, Royal Papworth Hospital NHS Trust, C, SC
*Purpose: Donor and recipient age at the time of lung transplantation (LTx) have been implicated in poor patient outcomes. The underlying mechanisms driving these effects…
2019 American Transplant Congress
Patient-Reported Self-Management in Lung Transplant Candidates
C. C. Kennedy¹, M. Budev², S. Chandrashekaran³, D. Erasmus⁴, E. D. Lease⁵, D. Levine⁶, K. Thompson¹, E. Stevens¹, R. Benzo¹
¹Mayo Clinic, Rochester, MN, ²Cleveland Clinic, Cleveland, OH, ³University of Florida- Gainesville, Gainesville, FL, ⁴Mayo Clinic, Jacksonville, FL, ⁵University of Washington, Seattle, WA, ⁶University of Texas Health Science Center San Antonio, San Antonio, TX
*Purpose: Pre-transplant risk factors are strongly associated with worse post-transplant survival (e.g. frailty); however, effective pre-transplant strategies to improve outcomes are lacking. We hypothesize that…
2019 American Transplant Congress
Opioid Use Policies and Practices in Liver Transplant and Lung Transplant Candidates: A Comparison of National Surveys
H. Bruschwein¹, V. Andersen¹, H. Patel², S. S. Rogal³, J. N. Fleming⁴
¹University of Virginia, Charlottesville, VA, ²University of North Carolina, Chapel Hill, NC, ³University of Pittsburgh, Pittsburgh, PA, ⁴Medical University of South Carolina, Charleston, SC
*Purpose: Pre-transplant opioid use has been associated with increased risk of morbidity and mortality. Alternatively, opioid substitution therapy (OST) has been proven to be a…