Articles tagged "Lung transplantation"

2019 American Transplant Congress
Waitlisted for Lung Transplant and the Role of Patient Travel Distance: A National Cohort Study
W. Tsuang, S. Arrigain, R. Lopez, M. Snair, K. McCurry, M. Budev, J. Schold
Cleveland Clinic, Cleveland, OH
*Purpose: Among patients waitlisted at the 75 lung transplant centers in the United States, the role of travel distance on waitlist outcomes is unknown. We…
2019 American Transplant Congress
Progress Using Genetically Engineered Pigs for Lung Xenotransplantation
L. Burdorf¹, C. Laird², S. Sendil², T. Zhang², D. Parsell², I. Tatarov², B. Cerel¹, Z. Abady¹, S. Pratts¹, C. J. Phelps³, D. L. Ayares³, A. M. Azimzadeh¹, R. N. Pierson III¹
¹Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Surgery, University of MD, Baltimore, MD, ³Revivicor, Blacksburg, VA
*Purpose: CRISPR/Cas9 gene editing techniques facilitate generation of pigs with multiple genetic modifications. We report results associated with multiple mechanistically targeted gene knock-outs and transgenes,…
2019 American Transplant Congress
Differential Impact of Donor and Recipient Age on Post-Lung Transplantation Outcomes
K. Patel¹, C. Li¹, C. Wallace¹, J. Kilkenny¹, D. P. Allen¹, S. Nadig¹, M. Goddard², C. Krieg¹, C. Atkinson¹
¹Surgery, Medical University of South Carolina, Charleston, SC, ²Pathology, Royal Papworth Hospital NHS Trust, C, SC
*Purpose: Donor and recipient age at the time of lung transplantation (LTx) have been implicated in poor patient outcomes. The underlying mechanisms driving these effects…
2019 American Transplant Congress
Patient-Reported Self-Management in Lung Transplant Candidates
C. C. Kennedy¹, M. Budev², S. Chandrashekaran³, D. Erasmus⁴, E. D. Lease⁵, D. Levine⁶, K. Thompson¹, E. Stevens¹, R. Benzo¹
¹Mayo Clinic, Rochester, MN, ²Cleveland Clinic, Cleveland, OH, ³University of Florida- Gainesville, Gainesville, FL, ⁴Mayo Clinic, Jacksonville, FL, ⁵University of Washington, Seattle, WA, ⁶University of Texas Health Science Center San Antonio, San Antonio, TX
*Purpose: Pre-transplant risk factors are strongly associated with worse post-transplant survival (e.g. frailty); however, effective pre-transplant strategies to improve outcomes are lacking. We hypothesize that…
2019 American Transplant Congress
Opioid Use Policies and Practices in Liver Transplant and Lung Transplant Candidates: A Comparison of National Surveys
H. Bruschwein¹, V. Andersen¹, H. Patel², S. S. Rogal³, J. N. Fleming⁴
¹University of Virginia, Charlottesville, VA, ²University of North Carolina, Chapel Hill, NC, ³University of Pittsburgh, Pittsburgh, PA, ⁴Medical University of South Carolina, Charleston, SC
*Purpose: Pre-transplant opioid use has been associated with increased risk of morbidity and mortality. Alternatively, opioid substitution therapy (OST) has been proven to be a…
2019 American Transplant Congress
A Metagene Signature of Lymphocytic Bronchitis Following Lung Transplantation
J. R. Greenland¹, P. Wang², J. J. Brotman², R. Ahuja¹, T. A. Chong², M. Kleinhenz², L. E. Leard², J. A. Golden², S. R. Hays², J. P. Singer², J. Kukreja³, N. Y. Greenland⁴, Z. Lasik⁴, P. Blanc¹
¹Medicine, VA Health Care System, San Francisco, CA, ²Medicine, University of California, San Francisco, CA, ³Surgery, University of California, San Francisco, CA, ⁴Pathology, University of California, San Francisco, CA
*Purpose: Lymphocytic bronchitis (LB) precedes chronic lung allograft dysfunction (CLAD). Peri-vascular (A-grade) and peri-bronchiolar (B-grade) lymphocytic inflammation are traditional markers of acute cellular rejection. The…
2019 American Transplant Congress
Exosomes Isolated from Human Lung Transplant Recipients Diagnosed with Bronchiolitis obliterans Syndrome are Unique in Their Ability to Induce IL-6 via Rab27A Signaling Pathway
M. Rahman, M. Sharma, S. Angara, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Rab27, a member of the Rab subfamily of GTPases, has the ability to induce exosome secretion. Exosomes are small membrane vesicles (40-150nm) that regulate…
2019 American Transplant Congress
Lung Allocation Score Should Be Implemented in China
C. Ju, Q. Lian, B. Wei, X. Xu, R. Chen, J. He
State Key Lab of the Respiratory Disease, Guangzhou Institute of Respiratory Disease, Guangzhou, China
*Purpose: Lung transplantation (LTx) is an effective treatment for patients with end stage of respiratory disease. Two of the major candidates are patients with chronic…
2019 American Transplant Congress
Unfavorable Donor after Cardiac Death Characteristics in Lung Transplantation: An Analysis of the UNOS Registry
A. Y. Choi¹, O. K. Jawitz², V. Raman², Y. Barac², M. S. Mulvihill², C. Moore², M. G. Hartwig²
¹Duke University School of Medicine, Durham, NC, ²Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Despite growing evidence that donation after circulatory death (DCD) lung transplants have comparable survival outcomes and primary graft dysfunction rates to donation after brain…
2019 American Transplant Congress
Transplanting Thoracic Organs From Hcv Donors To Uninfected Patients: Evaluation Of Lung Allografts
Y. Lo¹, R. F. Padera¹, H. R. Mallidi², H. J. Goldberg³, S. K. Singh², A. Coppolino, III⁴, L. R. Baden⁵, A. E. Woolley⁵
¹Pathology, Brigham and Womens Hospital, Boston, MA, ²Cardiac and Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ³Pulmonary, Brigham and Womens Hospital, Boston, MA, ⁴Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ⁵Infectious Diseases, Brigham and Womens Hospital, Boston, MA
*Purpose: Prior to the development of direct acting antiviral (DAA) therapy for hepatitis C virus (HCV), there was concern that patients who received lungs from…