Articles tagged "Lung transplantation"

2020 American Transplant Congress
The Forgiven Disease: Outcomes of Lung Transplantation in Two HIV-Infected Patients
S. Biswas Roy¹, M. T. Olson², M. A. Smith¹, R. M. Bremner¹, R. Walia¹, A. Arjuna¹
¹Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, ²University of Arizona College of Medicine - Phoenix, Phoenix, AZ
*Purpose: Human immunodeficiency virus (HIV) seropositivity is generally considered a contraindication to lung transplantation (LTx). HIV-infected adults are at higher risk of developing chronic lung…
2020 American Transplant Congress
Association between Mycoplasma and Ureaplasma Airway Colonization, Ammonia Levels and Outcomes Post Lung Transplantation
B. Buzo¹, J. Preiksaitis¹, K. Halloran², J. Nagendran³, D. Townsend⁴, N. Zelyas⁵, W. Sligl⁴
¹Infectious Diseases, Univ. of Alberta, Edmonton, AB, Canada, ²Pulmonary Medicine, Univ. of Alberta, Edmonton, AB, Canada, ³Cardiac Surgery, Univ. of Alberta, Edmonton, AB, Canada, ⁴Critical Care Medicine, Univ. of Alberta, Edmonton, AB, Canada, ⁵Lab Med & Pathology, Univ. of Alberta, Edmonton, AB, Canada
*Purpose: Hyperammonemia syndrome (HS) is a rare complication that can occur after lung transplantation. This syndrome is characterized by increased ammonia levels with altered sensorium,…
2020 American Transplant Congress
Association of Kidney Allograft Fibrosis-Associated Proteins with Chronic Lung Allograft Dysfunction
S. Farkona¹, G. Berra², Z. Mohammed-Ali¹, P. Ly², L. Levy², B. Renaud-Picard², G. Zehong², T. Daigneault², S. Juvet², C. McEvoy¹, S. Clotet-Freixas¹, T. Martinu², A. Konvalinka¹
¹Nephrology, Toronto General Hospital Research Institute and Multi-Organ Transplant, University Health Network, Toronto, ON, Canada, ²Lung Transplantation, Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) remains the leading cause of long-term mortality after lung transplant. Non invasive biomarkers that could assist in early diagnosis…
2020 American Transplant Congress
Granulocyte Colony Stimulating Factor: Trigger of Rejection in Lung Transplantation?
K. Walter¹, M. Patti¹, S. Khalid², L. Kemp¹, L. J. Lobo³, R. Coakley³, S. Krishnan³, C. T. Doligalski¹
¹University of North Carolina Medical Center, Chapel Hill, NC, ²Eshelman School of Pharmacy, Chapel Hill, NC, ³Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
*Purpose: Granulocyte colony stimulating factor (GCSF) is a management strategy for post-transplant neutropenia, but may increase the risk of rejection in lung transplant recipients (LTRs).…
2020 American Transplant Congress
Pleural Exosome Mediated Donor Antigen Trafficking Into Mediastinal Lymph Nodes Represents a Novel Pathway of Recipient T Cell Activation in Lung Transplantation
A. Habertheuer¹, A. Japp², C. Ram³, S. Chatterjee⁴, S. Rostami², L. Korutla⁵, T. Ochiya⁶, A. Naji², D. Kreisel⁷, P. Vallabhajosyula⁵
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Surgery, University of Pennsylvania, Philadelphia, PA, ³New York University, New York, NY, ⁴Pathology, University of Pennsylvania, Philadelphia, PA, ⁵Surgery, Yale University, New Haven, CT, ⁶National Cancer Center Japan, Tokyo, Japan, ⁷Surgery, Washington University, St. Louis, MO
*Purpose: Studies in lung transplant models suggest that reestablishment of lymphatic continuum of pulmonary allograft via lymphangiogenesis is required for selective trafficking of donor antigen…
2020 American Transplant Congress
Characteristics and Outcomes of Patients with Cystic Fibrosis Receiving Lung Transplant with and without ECMO Bridge – A Single Center Experience
J. Loeb, S. Pirrotta, P. Chung, S. Ganesh
Pulmonary & Critical Care, USC, Los Angeles, CA
*Purpose: ECMO is a viable bridge to lung transplantation (LTx) for end-stage cystic fibrosis (CF) patients refractory to traditional medical support. We sought to identify…
2020 American Transplant Congress
Survival after Lung Transplantation by Discharge Immunosuppressive Regimen: An Analysis of Organ Procurement and Transplantation Network Data
W. S. Cherikh¹, B. J. Plucinski¹, S. Palmer², W. E. Fitzsimmons³
¹United Network for Organ Sharing, Richmond, VA, ²Duke University Hospital, Durham, NC, ³Fitzsimmons LLC, Vernon Hills, IL
*Purpose: As the optimal immunosuppressive (IS) regimen after lung (LU) transplant (TX) is unknown, we conducted an analysis to compare the effect of four different…
2020 American Transplant Congress
Single Cell Gene Profiling Highlights Novel B Cell Populations Associated with the Development of Bronchiolitis Obliterates Syndrome after Lung Transplantation
N. F. Smirnova¹, K. Riemondy², S. Collins¹, J. Hesselberth², O. Eickelberg¹
¹Dept of Medicine - Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado - Anschutz Medical Campus, Aurora, CO, ²University of Colorado - Anschutz Medical Campus, Aurora, CO
*Purpose: The occurence of bronchiolitis obliterans syndrome (BOS) accounts for a poor long term prognosis after lung transplantation (LTx). Despite immunosuppressive T cell-targeting therapies the…
2020 American Transplant Congress
Transpulmonary Gradient as a Predictor for Outcomes after Single Lung Transplantation in Patients with Pulmonary Hypertension
A. Madde¹, E. Chan², J. Ryan², P. Reck Dos Santos², M. Morrell³, J. Luketich², P. Sanchez²
¹University of Pittsburgh School of Medicine, Pittsburgh, PA, ²UPMC Department of Cardiothoracic Surgery, Pittsburgh, PA, ³UPMC Division of Pulmonary Medicine, Pittsburgh, PA
*Purpose: End stage lung disease is commonly associated with pulmonary artery hypertension (PAH). In a donor restrictive environment, offering patients single over double lung transplants…
2020 American Transplant Congress
Isavuconazole (ISA) versus Voriconazole (VOR) Prophylaxis (px) in Lung Transplant Recipients (LTR)
P. Samanta, C. J. Clancy, R. V. Marini, R. Rivosecchi, E. K. McCreary, R. K. Shields, B. A. Falcione, A. Viehman, L. Sacha, E. J. Kwak, F. P. Silveira, L. Clarke, M. H. Nguyen
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: IFI is a significant complication following lung transplant (LT). VOR was universal antifungal (AF) px in our LT program from 2004-09/2015, at which time…