Articles tagged "Lung transplantation"

2020 American Transplant Congress
Safety and Immunogenicity of Adjuvanted Recombinant Subunit Herpes Zoster Vaccine in Lung Transplant Recipients
C. Hirzel¹, V. H. Ferreira¹, A. G. L’Huillier¹, T. Ku¹, M. Ierullo¹, C. Miao², D. S. Schmid², J. Tikkanen¹, L. G. Singer¹, A. Humar¹, D. Kumar¹
¹University Health Network, Toronto, ON, Canada, ²CDC, Atlanta, GA
*Purpose: The new adjuvanted subunit recombinant herpes zoster vaccine (RZV; Shingrix™) may have potential utility in transplant patients for the prevention of shingles, but there…
2020 American Transplant Congress
Effects of Subnormothermic Ex Vivo Lung Perfusion on Inflammatory Injury in a Murine Lung Transplant Model
J. N. Gloria¹, S. J. Kesseli², J. Yerxa², M. Zhang², M. Zhu², W. Parker², R. P. Davis², A. S. Barbas², M. G. Hartwig³
¹Duke University School of Medicine, Durham, NC, ²Department of Surgery, Duke University Medical Center, Durham, NC, ³Department of Thoracic Surgery, Duke University Medical Center, Durham, NC
*Purpose: Ex vivo lung perfusion (EVLP) has emerged as a technique that safely preserve lungs prior to transplantation. Recent evidence demonstrates increased levels of inflammatory…
2020 American Transplant Congress
Evaluation of the Mitra Microsampling Device for TTV Measurement in Human Whole Blood of Lung Transplant Recipients
J. Mühlbacher¹, B. Lickefett¹, K. Doberer², B. Reiter³, S. Aberle⁴, G. Bond², P. Jaksch¹
¹Department of Surgery, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Medical University of Vienna, Vienna, Austria, ³Clinical Institute of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, ⁴Department of Virology, Medical University of Vienna, Vienna, Austria
*Purpose: The apathogenic Torque Teno Virus (TTV) is highly prevalent among solid organ transplant recipients and mirrors the immunocompetence of its host. qPCR based measurement…
2020 American Transplant Congress
Improved Kidney Function Post Lung Transplant with Intravenous Tacrolimus Avoidance
C. Burt¹, A. Feist¹, K. Afshar², L. Awdishu¹, M. Mariski¹, J. Kozuch¹, G. Yung², E. Golts³
¹Pharmacy, UC San Diego Health, San Diego, CA, ²Pulmonology, UC San Diego Health, San Diego, CA, ³Cardiothoracic Surgery, UC San Diego Health, San Diego, CA
*Purpose: Tacrolimus (TAC) poses a dose-dependent risk of acute kidney injury (AKI) as well as chronic kidney disease (CKD) post-transplant. In 2017, our institution’s lung…
2020 American Transplant Congress
Bilateral Lung Transplantation Combined with Cardiac Correction in Treatment of Severe Pulmonary Arterial Hypertension Complicated with Eisenmenger Syndrome in Puerpera, a Feasible Strategy for Future?
J. Huang, Z. Wang, J. Chen
Wuxi Lung Transplant Center, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China
*Purpose: Though pregnancy is not recommended for patients with pulmonary arterial hypertension (PAH) in current guidelines, some patients do stick to parturition due to varies…
2020 American Transplant Congress
The Impact of Thy1 Expression of Fibroblast for Chronic Lung Allograft Dysfunction
A. Hata¹, Y. Guo¹, D. Li¹, Z. Mei¹, A. Manafi¹, A. Banerjee¹, B. Mahgoub¹, T. H. Barker², A. S. Krupnick¹
¹Surgery, University of Virginia, Charlottesville, VA, ²Biomedical Engineering, University of Virginia, Charlottesville, VA
*Purpose: Chronic lung allograft dysfunction (CLAD) result from excessive immune activation and excessive collagen deposition by fibroblasts within the lung parenchyma or airway.Bronchiolitis obliterans (OB)…
2020 American Transplant Congress
A Survey of Lung Transplant Recipient Attitudes and Beliefs on Accepting an Organ That Was Positive for Hepatitis C Virus
S. S. Humar¹, N. Pinzon¹, M. Cypel¹, S. Abbey²
¹University Health Network, Transplant Center, Toronto, ON, Canada, ²University Health Network, Center for Mental Health, Toronto, ON, Canada
*Purpose: Recent data show that organs from donors who are HCV positive (+ve) can be safely transplanted into HCV negative recipients. We conducted a survey…
2020 American Transplant Congress
Use of 16S Sequencing to Reveal Potential Respiratory Pathogens in Lung Transplant Recipients
C. Eskind¹, M. Shilts¹, H. Boone¹, J. Schmitz², C. Shaver³, S. Das¹, G. Satyanarayana¹
¹Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, ²Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, ³Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN
*Purpose: Respiratory infections are common after lung transplant and contribute to mortality and allograft failure. 16S ribosomal RNA (rRNA) gene sequencing could facilitate diagnosis of…
2020 American Transplant Congress
Lung Mucosal Biopsies Deteriorate with Time Post-Transplant: A Molecular Analysis
M. D. Parkes¹, P. Halloran¹, K. Halloran², &. the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Mucosal biopsies from the third airway bifurcation (3BMBs) assessed molecularly can be used to detect rejection (DOI: 10.1111/ajt.15685), and may also provide insights into…
2020 American Transplant Congress
The Study of Continuous Renal Replacement Therapy Performing in Pre-Retrieval Management of Marginal Criteria Donor Lung: A Retrospective Control Study
J. Huang¹, X. Zheng², Z. Wang¹, M. Huang², J. Chen¹
¹Wuxi Lung Transplant Center, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China, ²General ICU, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
*Purpose: Ex vivo lung perfusion (EVLP) has successfully been applied to the management of marginal donor lungs, while the high cost and equipment lacking restrict…