Articles tagged "Lung transplantation"

2020 American Transplant Congress
Proteomic Profiling of Circulating Extracellular Vesicles Isolated from Human Lung Transplant Recipients
S. Bansal¹, M. McGilvrey², K. Garcia-Mansfield², R. Sharma², R. Bremner¹, M. Smith¹, R. Hachem³, P. Pirrotte², T. Mohanakumar¹
¹Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, ²Translational Genomics Research Institute (TGen), Collaborative Center for Translational Mass Spectrometry (CCTMS), Phoenix, AZ, ³Department of Medicine, Washington University School of Medicine, Phoenix, AZ
*Purpose: Circulating exosomes in human lung transplant recipients (LTxRs) with acute (AR) and chronic rejection (bronchiolitis obliterans syndrome [BOS]) contain donor human leukocyte antigen (HLA)…
2020 American Transplant Congress
Late Onset Primary Graft Dysfunction after Lung Transplantation Correlates with Transplant Arteriosclerosis in a Humanized Mouse Model
M. Franz¹, T. Siemeni¹, A. Knöfel¹, W. Sommer¹, M. Avsar¹, F. Ius¹, I. Tudorache¹, C. Kühn¹, C. S. Falk², G. Warnecke¹, A. Haverich¹
¹Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ²IFB-Tx, Hannover Medical School, Hannover, Germany
*Purpose: Primary Graft dysfunction (PGD) is one of the most important causes of early mortality after lung transplantation. We investigated the correlation between the incidence…
2020 American Transplant Congress
Dosing and Outcomes of Conversion to Extended-Release Tacrolimus in Heart and Lung Transplant Recipients
C. Doligalski¹, K. Walter¹, P. Chang², L. J. Lobo²
¹University of North Carolina Medical Center, Chapel Hill, NC, ²Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
*Purpose: Extended release tacrolimus (LCP-Tac) is a novel once daily formulation with improved pharmacokinetic parameters compared to immediate release tacrolimus (IR-Tac). LCP-Tac use in renal…
2020 American Transplant Congress
Glucocorticoid-Induced Osteoporosis in Lung Transplant Patients
J. Clark, L. Potter
Department of Pharmacy, University of Chicago Medicine, Chicago, IL
*Purpose: Although vital for preventing rejection, glucocorticoids contribute to post-operative morbidity, including osteoporosis. The primary purpose of this study was to identify the occurrence of…
2020 American Transplant Congress
Divergent Molecular Pathways Underlie the Evolution of Allograft Fibrosis in Two Mouse Models of Chronic Lung Allograft Dysfunction
T. Watanabe, J. Allen, K. Boonstra, Z. Guan, K. Bei, S. Keshavjee, J. Yeung, T. Martinu, S. Juvet
Latner Thoracic Surgery Research Laboratories, Toronto Lung Transplant Program / University Health Network, Toronto, ON, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) is potentiated by activation of the innate immune system and occurs in two patterns: diffuse…
2020 American Transplant Congress
Safety and Immunogenicity of Adjuvanted Recombinant Subunit Herpes Zoster Vaccine in Lung Transplant Recipients
C. Hirzel¹, V. H. Ferreira¹, A. G. L’Huillier¹, T. Ku¹, M. Ierullo¹, C. Miao², D. S. Schmid², J. Tikkanen¹, L. G. Singer¹, A. Humar¹, D. Kumar¹
¹University Health Network, Toronto, ON, Canada, ²CDC, Atlanta, GA
*Purpose: The new adjuvanted subunit recombinant herpes zoster vaccine (RZV; Shingrix™) may have potential utility in transplant patients for the prevention of shingles, but there…
2020 American Transplant Congress
Effects of Subnormothermic Ex Vivo Lung Perfusion on Inflammatory Injury in a Murine Lung Transplant Model
J. N. Gloria¹, S. J. Kesseli², J. Yerxa², M. Zhang², M. Zhu², W. Parker², R. P. Davis², A. S. Barbas², M. G. Hartwig³
¹Duke University School of Medicine, Durham, NC, ²Department of Surgery, Duke University Medical Center, Durham, NC, ³Department of Thoracic Surgery, Duke University Medical Center, Durham, NC
*Purpose: Ex vivo lung perfusion (EVLP) has emerged as a technique that safely preserve lungs prior to transplantation. Recent evidence demonstrates increased levels of inflammatory…
2020 American Transplant Congress
Evaluation of the Mitra Microsampling Device for TTV Measurement in Human Whole Blood of Lung Transplant Recipients
J. Mühlbacher¹, B. Lickefett¹, K. Doberer², B. Reiter³, S. Aberle⁴, G. Bond², P. Jaksch¹
¹Department of Surgery, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Medical University of Vienna, Vienna, Austria, ³Clinical Institute of Laboratory Medicine, Medical University of Vienna, Vienna, Austria, ⁴Department of Virology, Medical University of Vienna, Vienna, Austria
*Purpose: The apathogenic Torque Teno Virus (TTV) is highly prevalent among solid organ transplant recipients and mirrors the immunocompetence of its host. qPCR based measurement…
2020 American Transplant Congress
Improved Kidney Function Post Lung Transplant with Intravenous Tacrolimus Avoidance
C. Burt¹, A. Feist¹, K. Afshar², L. Awdishu¹, M. Mariski¹, J. Kozuch¹, G. Yung², E. Golts³
¹Pharmacy, UC San Diego Health, San Diego, CA, ²Pulmonology, UC San Diego Health, San Diego, CA, ³Cardiothoracic Surgery, UC San Diego Health, San Diego, CA
*Purpose: Tacrolimus (TAC) poses a dose-dependent risk of acute kidney injury (AKI) as well as chronic kidney disease (CKD) post-transplant. In 2017, our institution’s lung…
2020 American Transplant Congress
Bilateral Lung Transplantation Combined with Cardiac Correction in Treatment of Severe Pulmonary Arterial Hypertension Complicated with Eisenmenger Syndrome in Puerpera, a Feasible Strategy for Future?
J. Huang, Z. Wang, J. Chen
Wuxi Lung Transplant Center, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China
*Purpose: Though pregnancy is not recommended for patients with pulmonary arterial hypertension (PAH) in current guidelines, some patients do stick to parturition due to varies…