Articles tagged "Lung transplantation"

2021 American Transplant Congress
Lung Transplant Recipients with Severe Acute Respiratory Syndrome-Coronavirus 2 Infection and Asymptomatic Carriers Waiting for Lung Transplantation Induce Circulating Exosomes with Severe Acute Respiratory Syndrome-Coronavirus 2 Spike Protein S2
S. Bansal, S. Tokman, T. Fleming, M. Smith, R. Bremner, T. Mohanakumar
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Exosomes are vesicles released by cells into body fluids. We demonstrated increased circulating exosomes with lung self-antigens (Collagen V, Kα1 Tubulin) and viral antigens…
2021 American Transplant Congress
COVID-19 Infection in Kidney versus Non-kidney Solid Organ Transplant Recipients: A Single Center Study
J. Schaenman¹, H. Byford², T. R. Grogan³, S. Fraschilla², K. Meneses⁴, J. C. Alejos⁵, M. Rivera⁶, S. Saab⁷
¹Infectious Diseases, UCLA, Los Angeles, CA, ²Transplant Administration, UCLA, Los Angeles, CA, ³Division of General Internal Medicine and Health Services Research, UCLA, Los Angeles, CA, ⁴Liver Transplantation, UCLA, Los Angeles, CA, ⁵Pediatric Heart Transplantation, UCLA, Los Angeles, CA, ⁶Pediatric Kidney Transplantation, UCLA, Los Angeles, CA, ⁷Liver Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: The COVID-19 pandemic has caused significant morbidity and mortality in patients around the world. A significant impact has been observed in immunocompromised patients such…
2021 American Transplant Congress
Evaluation of Pepsin in Bronchoalveolar Lavage Fluid Post-lung Transplantation: Implications of Detection
M. T. Olson, C. Rogers, K. McAnally, A. Arjuna
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: This preliminary investigation in three lung transplant recipients aimed to measure pepsin, as a marker of gastric microaspiration, in bronchoalveolar lavage fluid (BAL) fluid,…
2021 American Transplant Congress
Assessing the Accuracy of the Lung Allocation Score
N. Dussault¹, W. Parker¹, R. Jablonski¹, E. Garrity¹, M. Churpek²
¹University of Chicago, Chicago, IL, ²University of Wisconsin-Madison, Madison, WI
*Purpose: The Lung Allocation Score (LAS) relies on the performance of two cox proportional hazards models that estimate waitlist and post-transplant survival. These models were…
2021 American Transplant Congress
Impact of Lung Allocation Score Cohort Update
M. Skeans¹, A. Wey¹, E. Lease², C. Lehr³, M. Valapour³
¹SRTR, Minneapolis, MN, ²Univ of Washington, Seattle, WA, ³Cleveland Clinic, Cleveland, OH
*Purpose: The lung allocation score (LAS) was last revised in February, 2015, based on waitlist (WL) and posttransplant (PT) survival model cohorts from 2006-2008 and…
2021 American Transplant Congress
Polyomavirus BK-Associated Nephropathy in Patients After Renal and Extrarenal Transplantation
A. Schwarz¹, J. Schmitz², J. Braesen², C. Bara³, M. Sauer⁴, H. Haller¹, J. Gottlieb⁵
¹Nephrology Department, Hannover Medical School, Hannover, Germany, ²Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Thoracic Surgery, Hannover Medical School, Hannover, Germany, ⁴Department of Pediatric Hematology, Hannover Medical School, Hannover, Germany, ⁵Deparment of Pneumology, Hannover Medical School, Hannover, Germany
*Purpose: Patients with non-renal organ transplantation (TX) may suffer BK-viral nephropathy (BKVN) of their own orthotopic kidneys. We aimed to know if these patients with…
2021 American Transplant Congress
A Retrospective Analysis of the Safety and Efficacy of Apixaban After Lung Transplant
T. Sam¹, K. Reininger², R. Patel¹, C. Naik¹, K. Ausloos¹, R. Rosenblatt¹, T. Grazia¹, I. Lam³
¹Transplant, Baylor University Medical Center, Dallas, TX, ²Transplant, Hennepin County Medical Center, Minneapolis, MN, ³Transplant, Sharp Memorial Hospital, San Diego, CA
*Purpose: Atrial arrhythmias and venous thromboembolism (VTE) are common after lung transplant. While direct acting oral anticoagulants (DOACs) have become anticoagulants of choice in atrial…
2021 American Transplant Congress
Liver Kinase B1 Knockdown Induces Platelet-Derived Growth Factor Receptor B Expression in Human Airway Epithelial Cells: A Potential Mechanism for Development of Fibrosis Leading to Chronic Lung Allograft Dysfunction
M. Rahman, J. Lee, R. Ravichandran, T. Fleming, M. Smith, R. Bremner, T. Mohanakumar
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The platelet-derived growth factor and its receptor (PDGFRb) signaling pathway can be activated by epithelial mesenchymal transition which facilitates fibrosis. It is not known…
2021 American Transplant Congress
Evaluating Pneumocystis Jiroveci Pneumonia Prophylaxis in Lung Transplant Recipients
J. Sharkey, K. McMurry, J. Park, C. Carlson, K. Gregg, D. Kaul, D. Lyu, L. Fitzgerald
Michigan Medicine, Ann Arbor, MI
*Purpose: The incidence of Pneumocystis jiroveci pneumonia (PJP) in lung transplant recipients (LTRs) on PJP prophylaxis is not well documented yet reported as high as…
2021 American Transplant Congress
BK Virus-associated Nephropathy as a Cause of Renal Failure Post-lung Transplantation
A. Arjuna, M. T. Olson, B. Buddhdev, R. Tenorio, A. Omar, S. Tokman
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: BK virus-associated nephropathy (BKVAN) is a common cause of renal dysfunction early after renal transplant. BKVAN is much rarer in non-renal solid organ transplant,…