2021 American Transplant Congress
Accelerated Bronchiolitis Obliterans After Lung Transplant Promoted by an ATG16L1 Mutation is Coupled to Mitochondrial Damage and Metabolic Alterations in Monocyte-derived Antigen Presenting Cells
1Washington University, Saint Louis, MO, 2UT Southwestern Medical Center, Dallas, TX
*Purpose: Bronchiolitis obliterans (BOS) remains a major cause of death for lung transplant recipients, and the mechanisms that drive BOS remain poorly understood. It is…2021 American Transplant Congress
Antibody-mediated Rejection and Sponge Effect in a Redo Lung Transplant Recipient: A Case Report
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: Antibody-mediated rejection (AMR) typically presents with elevated titers of circulating donor specific antibodies (DSA) and increased mean fluorescence intensity (MFI), a surrogate marker for…2021 American Transplant Congress
Bilateral Lung Transplantation for Destroyed Lungs with Asymmetric Thorax
Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, China
*Purpose: Destroyed lungs can cause mediastinal displacement, asymmetric chest deformity, and high risk and difficulty of surgery. Until now, there are few reports about bilateral…2021 American Transplant Congress
Perioperative Blood Transfusion is Associated with the Development of New HLA Antibodies After Adult Lung Transplantation
*Purpose: Lung transplant (LT) recipients who develop new antibodies to human leukocyte antigen (HLA) have associated with chronic lung allograft dysfunction and worsened outcomes. We…2021 American Transplant Congress
Randomized Phase 3 Open-label Study of Maribavir vs Investigator-assigned Therapy for Refractory/resistant Cytomegalovirus Infection in Transplant Recipients: Subgroup Analyses of Efficacy by Organ
*Purpose: Therapeutic options for refractory, with/without resistance (R/R), CMV infections are limited. We report organ type subgroup analyses from a large multi-center trial that studied…2021 American Transplant Congress
Long-Term Renal Outcomes in Lung Transplant Recipients- A Single-Center Five-Year Experience
Comprehensive Transplant Center, The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: The increased longevity in Lung transplant (LTx) has led to an upsurge in chronic medical comorbidities, including Acute kidney injury (AKI), Chronic kidney disease…2021 American Transplant Congress
Incidentally Detected Malignancies in Lung Explants: Single Center Case Series
*Purpose: Thoracic malignancies are difficult to prospectively diagnose in patients with end-stage lung disease due to complex radiologic features. We present a series of lung…2021 American Transplant Congress
A Randomized, Multicenter, Blinded Study Assessing the Effects of Gaseous Nitric Oxide in an Ex Vivo System of Human Lungs
*Purpose: The effects of nitric oxide (NO) on donor lungs during ex vivo lung perfusion (EVLP) have not been studied. We assessed whether the novel…2021 American Transplant Congress
Alpha 1-antitrypsin Reduces Cytokine Elaboration in a Xenogeneic Lung Transplantation Model
*Purpose: Novel gene editing techniques have facilitated the generation of donor pigs with multiple genetic modifications, used for xenolung transplantation. Several rejection pathways, including antibody…2021 American Transplant Congress
A Case-Match Cohort Comparison of the Safety and Efficacy of Basiliximab for Immunosuppression Holiday in Lung Transplant Patients
1Pharmacy, Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA
*Purpose: Post-transplant complications related to calcineurin inhibitors (CNI) maintenance immunosuppression (MI) may require interim alternative therapies. The goal of this study is to evaluate the…
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