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American Transplant Congress abstracts

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Articles tagged "Lung preservation"

  • 2021 American Transplant Congress

    Lung Transplantation After Ex-Vivo Lung Perfusion versus Static Cold Storage: A Single Institution Cost Analysis

    S. E. Halpern1, S. J. Kesseli2, S. Au1, M. K. Krischak1, D. G. Olaso1, H. Smith3, G. Tipton2, I. Jamieson3, J. C. Haney2, J. A. Klapper2, M. G. Hartwig2

    1Duke University School of Medicine, Durham, NC, 2Surgery, Duke University Medical Center, Durham, NC, 3Office of Finance, Duke Transplant Center, Durham, NC

    *Purpose: Ex-vivo lung perfusion (EVLP) allows for reconditioning of “marginal” lung grafts and extended lung preservation. However, EVLP is costlier than cold storage. We compared…
  • 2020 American Transplant Congress

    Pilot Study: Effect of Dual Ex Vivo Lung Perfusion on Human Lung Preservation

    K. Noda1, J. Sembrat2, B. J. Philips1, T. Harano1, M. Rojas2, P. G. Sanchez1, N. Shigemura3

    1Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, 2Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, 3Division of Cardiovascular Surgery, Temple University, Philadelphia, PA

    *Purpose: We have developed a novel lung preservation technique, dual ex vivo lung perfusion (dual EVLP) where both pulmonary artery (PA) and bronchial artery (BA)…
  • 2020 American Transplant Congress

    Effects of Subnormothermic Ex Vivo Lung Perfusion on Inflammatory Injury in a Murine Lung Transplant Model

    J. N. Gloria1, S. J. Kesseli2, J. Yerxa2, M. Zhang2, M. Zhu2, W. Parker2, R. P. Davis2, A. S. Barbas2, M. G. Hartwig3

    1Duke University School of Medicine, Durham, NC, 2Department of Surgery, Duke University Medical Center, Durham, NC, 3Department of Thoracic Surgery, Duke University Medical Center, Durham, NC

    *Purpose: Ex vivo lung perfusion (EVLP) has emerged as a technique that safely preserve lungs prior to transplantation. Recent evidence demonstrates increased levels of inflammatory…
  • 2020 American Transplant Congress

    A Large Animal Model of Ex-Vivo Lung Perfusion as a Platform to Deliver Therapeutic Agents to Lungs Before Lung Transplant

    T. M. Egan1, B. Haithcock1, M. H. Ali1, J. W. Blackwell1, B. Masuodi1, S. Shipley2, T. Long3, A. Akerman1, S. Montgomery4, H. Yuan5, P. Stewart6, J. Potenziano7, C. Sekaran7, R. Fitch7

    1Surgery, UNC at Chapel Hill, Chapel Hill, NC, 2Department of Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, 3Pathology and Laboratory Medicine,, UNC at Chapel Hill, Chapel Hill, NC, 4Pathology and Laboratory Medicine, UNC at Chapel Hill, Chapel Hill, NC, 5Radiology, UNC at Chapel Hill, Chapel Hill, NC, 6Gillings Global School of Public Health, UNC at Chapel Hill, Chapel Hill, NC, 7Mallinckrodt Pharmaceuticals, Hazelwood, MO

    *Purpose: Ex-vivo lung perfusion (EVLP) has been used to evaluate lung function before lung transplant (LT). We used EVLP to expose lungs recovered 6 hours…
  • 2020 American Transplant Congress

    The Ratio between Naïve and Memory B Cells is Associated with Development of Early Donor-Specific Antibodies within the First Month after Lung Transplantation

    A. Hitz1, R. Bellmàs Sanz1, F. Ius2, J. Kühne1, B. Wiegmann2, W. Sommer2, J. Salman2, T. Siemeni2, C. Kühn2, M. Avsar2, A. Haverich2, I. Tudorache2, G. Warnecke2, C. Falk1

    1Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany

    *Purpose: After lung transplantation (LuTx), the development of early donor HLA-specific antibodies (eDSA) has been shown to be associated with antibody-mediated rejection (AMR) and poor…
  • 2020 American Transplant Congress

    Perioperative Results of Lung Transplantation in a Newly Established, High-Volume Lung Transplantation Center in China

    F. Xiao1, Z. Zhang1, H. Feng1, M. Li2, W. Chen3, C. Liang1, J. Chen3

    1Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing, China, 2Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China, 3Department of Lung Transplantation, China-Japan Friendship Hospital, Beijing, China

    *Purpose: The number of patients with end-stage lung disease is huge in China, lung transplantation is the only effective method. By presenting the perioperative results…
  • 2020 American Transplant Congress

    Ex Vivo Pumping Through an OPO’s Eyes

    A. L. Friedman, E. Marquez

    LiveOnNY, New York, NY

    *Purpose: A single, large organ procurement organization (OPO) sought to document the use of extra-renal ex vivo pumping in the management of the deceased donor…
  • 2019 American Transplant Congress

    The Frequency of Tissue-Resident Donor T and NK Cells in Peripheral Blood after Lung Transplantation is Modulated by Normothermic Ex Vivo Lung Perfusion

    C. S. Falk1, B. Wiegmann2, A. Hitz1, R. Bellmas-Sanz1, K. Bläsing1, F. Ius2, C. Kühn2, M. Avsar2, I. Tudorache2, J. Kühne1, F. Wandrer1, A. Haverich2, G. Warnecke2

    1Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany

    *Purpose: The appearance of passenger donor lymphocytes in recipient blood after double lung transplantation has been described decades ago. However, neither their early kinetics, nor…
  • 2019 American Transplant Congress

    Total Parenteral Nutrition in Ex Vivo Lung Perfusion: Addressing Metabolism Improves Both Inflammation and Overall Graft Performance

    M. T. Buchko, S. Hatami, C. J. Stewart, S. Himmat, D. H. Freed, J. Nagendran

    Department of Surgery, Division of Cardiac Surgery, University of Alberta, Edmonton, AB, Canada

    *Purpose: Contemporary clinical ex vivo lung perfusion (EVLP) protocols generally limit metabolic supplementation to insulin and glucose. Furthermore, conventional perfusates are void of many ingredients…
  • 2019 American Transplant Congress

    Flow Cytometric Analysis of Leukocyte Migration during Ex Vivo Lung Perfusion with CXCR4 Inhibition

    J. Yerxa1, Q. Gao1, R. P. Davis2, M. Zhang1, U. Scheuermann1, W. Parker1, M. G. Hartwig2, A. Barbas1

    1General Surgery, Duke University, Durham, NC, 2Thoracic Surgery, Duke University, Durham, NC

    *Purpose: Ex vivo lung perfusion (EVLP) has emerged as a preservation technique utilized to evaluate candidate donor lungs in a metabolically active state. This also…
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