Articles tagged "Liver"

2017 American Transplant Congress
Platelets Stimulate Liver Sinusoidal Endothelial Cells to Secrete Interleukin-6 During the Early Phase of Liver Regeneration in Mice.
J. Meyer,^1,2 E. Perroud,² P. Fontana,^3,4 K. Sadoul,⁵ P. Morel,^1,2 C. Gonelle-Gispert,² L. Bühler.^1,2
¹Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; ²Unit of Surgical Research, University of Geneva, Geneva, Switzerland; ³Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland; ⁴Geneva Platelet Group, University of Geneva, Geneva, Switzerland; ⁵Institute for Advanced Biosciences, Inserm U1209, Grenoble, France
Background and aimsPlatelets and liver sinusoidal endothelial cells (LSEC) are known to both independently regulate liver regeneration. Our aim was to investigate the role of…
2017 American Transplant Congress
Life Threatening Disparities in Calculated MELD Due to Variation in Laboratory Methods within a UNOS Region.
E. Verna,¹ C. Connelly,¹ L. Dove,¹ J. Emond,¹ P. Adem,² N. Babic,³ J. Corsetti,⁴ J. Faix,⁵ J. Hayden,⁶ M. Lifshitz,⁷ M. Chiles,¹ S. Mohan,¹ H. Eldad,¹ A. Kratz.¹
¹CUMC, NY; ²WMC, NY; ³MSSM, NY; ⁴URMC, Rochester; ⁵MMC, NY; ⁶WCM, NY; ⁷NYU, NY
MELD was implemented as an objective measure to prioritize patients for liver transplant (LT). Accuracy and reproducibility of MELD is an essential assumption to ensure…
2017 American Transplant Congress
Isoflurane Precondition Alleviated Murine Liver Ischemia and Reperfusion Injury by Restoring AMPK/mTOR-Mediated Autophagy.
Z. Rao,¹ H. Zhou,² X. Pan,¹ M. Gao,¹ Z. Wang,¹ J. Sun,¹ C. Liu,¹ Z. Ding.¹
¹Department of Anesthesiology, First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China; ²Department of Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background: Isoflurane has a pharmacological precondition effect against ischemia injury in the heart, kidney and brain, but whether and how isoflurane precondition protects livers against…
2017 American Transplant Congress
Toll-Like Receptor 4-Dependent CCAAT-Enhancer-Binding Protein Homologous Protein Activation Induces Hepatocellular Cell Death in Liver Ischemia and Reperfusion Injury.
H. Zhou,¹ Z. Rao,² H. Wang,¹ X. Wang,¹ L. Lu.¹
¹Department of Liver Surgery, First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China; ²Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background: Critical role of Toll-like receptor 4(TLR4) and endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the relationship between…
2017 American Transplant Congress
MELD Exception Score: LSAM Modeling of a Fixed Floor.
J. Heimbach,¹ R. Hirose,² D. Schladt,³ J. Pyke,³ J. Zeglin,³ S. Leppke,³ J. Lake,⁴ W. Kim.^5,3
¹Mayo Clinic, Rochester; ²UCSF, San Francisco; ³SRTR, Minneapolis; ⁴Univ of Minnesota, Minneapolis; ⁵Stanford Univ, Stanford
Current US liver allocation policy grants standard MELD score exceptions beginning at 22 points and rising every 3 months. Scores for hepatocellular cancer are delayed…
2017 American Transplant Congress
Porcine Albumin Elaboration During Perfusion of Transgenic Porcine Livers with Human Blood.
A. Cimeno,¹ J. Powell,¹ B. French,¹ D. Ayares,² A. Azimzadeh,¹ R. Pierson III,¹ R. Barth,¹ J. LaMattina.
¹Department of Surgery, University of Maryland, School of Medicine, Baltimore, MD; ²Revivicor, Inc., Blacksburg, VA
PurposeIn addition to immune barriers, molecular incompatibilities between species are predicted to limit pig liver survival in primate xenotransplantation models. How perfusion with human blood…
2017 American Transplant Congress
NAFLD in Kidney Transplant Candidates.
N. Kemmer, J. Buggs.
Tampa General Medical Group, Tampa, FL
Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause for liver transplant, and it is the most rapidly growing indication for simultaneous liver-kidney transplant…
2017 American Transplant Congress
Women Are Delisted for Being Too Sick for Liver Transplant More Frequently Than Men.
G. Cullaro, J. Lai.
University of California - San Francisco, San Francisco, CA
Background: Women (W) with cirrhosis awaiting liver transplantation (LT) experience higher rates of waitlist mortality than men (M). We aimed to understand the impact of…
2017 American Transplant Congress
The Adoption of Generic Immunosuppressant Medications Among Kidney and Liver Transplant Recipients Using the Colorado All Payer Claims Database.
Q. Liu,¹ A. Smith,¹ J. Park,² M. Oguntimein,³ S. Dutcher,³ G. Bello,¹ M. Helmuth,¹ M. Turenne,¹ R. Balkrishnan,⁴ M. Fava,¹ P. Sharma,² C. Beil,¹ A. Leichtman,¹ J. Zee.¹
¹Arbor Research Collaborative for Health, Ann Arbor, MI; ²U of Michigan, Ann Arbor, MI; ³Food and Drug Administration, Silver Spring, MD; ⁴U of Virginia, Charlottesville, VA
Background: Substitution of generic for brand-name immunosuppressants has increased in solid organ transplantation following the expiration of brand patents. Our aim was to describe the…
2017 American Transplant Congress
Polycystic Liver Disease Patients May Not Be Appropriately Represented by MELD Exception Policy.
S. Chandradas,¹ J. Waalen,² C. Frenette.¹
¹Organ Transplant, Scripps Clinic, La Jolla, CA; ²Scripps Translational Science Institute, La Jolla, CA
Purpose: Polycystic liver disease (PCLD) is a rare, but important disease whose mortality is not fully predicted by MELD score. Most patients with PCLD maintain…