Articles tagged "Liver"

2018 American Transplant Congress
Diffuse Optical Non-Invasive Organ Risk (DONOR) Indexing Using Diffuse Reflectance Spectroscopy for Pre-Transplant Evaluation
H. Borron,¹ D. Piao,² A. Hawxby,³ H. Wright,³ E. Rubin.⁴
¹College of Medicine, University of Oklahoma, Oklahoma City, OK; ²School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, OK; ³Oklahoma Transplant Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK; ⁴Pathology, University of Oklahoma, Oklahoma City, OK.
Purpose: Due to large transplant waitlists, a rapid, non-invasive method to evaluate organ quality for transplantation is needed. Diffuse optical spectroscopy (DOSi) is an optical…
2018 American Transplant Congress
Role of Obesity in Pediatric Liver Transplantation
K. Covarrubias, M. Denhard, X. Luo, J. Garonzik-Wang, A. Cameron, D. Segev, D. Mogul.
JHU, Baltimore, MD.
PURPOSE: Pediatric obesity rates are climbing and the prevalence of obesity in children undergoing liver transplantation now exceeds that of the general population. Studies in…
2018 American Transplant Congress
Technical Aspects of Orthotopic Liver Transplantation – A Survey-Based Study within the Eurotransplant, Swisstransplant, Scandiatransplant and British Transplantation Society Networks
Z. Czigany,¹ J. Bednarsch,¹ J. Böcker,¹ F. Meister,¹ I. Amygdalos,¹ W. Schöning,¹ T. Ulmer,¹ X. Rogiers,² P. Dutkowski,³ P-.D. Line,⁴ M. Malagó,⁵ U. Neumann,¹ G. Lurje.¹
¹Department of Surgery and Transplantation, University Hospital RWTH, Aachen, Germany; ²Department of Solid Organ Transplantation, University Hospital Gent, Gent, Belgium; ³Department of Surgery and Transplantation, University Hospital Zurich, Zurich, Switzerland; ⁴Department of Solid Organ Transplantation, University Hospital Oslo, Oslo, Norway; ⁵Department of Hepatobiliary Surgery and Transplantation, University College London, London, United Kingdom.
Background: Surgical aspects of ortoptopic liver transplantation (OLT) are widely based on low-level evidence as well as on local institutional protocols. Aim of this study…
2018 American Transplant Congress
The Predictive Power of MELD is Decreasing in the Era of Older, Sicker Patients
E. Godfrey,¹ J. Lai,² T. Miloh,³ N. Galvan,¹ R. Cotton,¹ C. O'Mahony,¹ J. Vierling,¹ N. Sussman,¹ A. Rana.¹
¹Department of Surgery, Baylor College of Medicine, Houston, TX; ²Department of Medicine, University of California, San Francisco, San Francisco, CA; ³Department of Pediatrics, Baylor College of Medicine, Houston, TX.
PurposeThe field of liver transplantation has shifted considerably in the MELD era. Liver allocation, immunosuppression, and etiologies of liver failure have changed over time, and…
2018 American Transplant Congress
Differences in Liver Waitlist Mortality Due to Geographic Disparity in Organ Availability
A. Massie,¹ S. DiBrito,¹ J. Motter,¹ M. Henderson,¹ S. Zhou,¹ K. Jackson,¹ D. Segev,¹ S. Gentry.²
¹Johns Hopkins, Baltimore; ²US Naval Academy, Annapolis.
DSA-level geographic disparity in access to liver transplantation for waitlisted patients has been described, but the impact of this disparity on waitlist mortality is poorly…
2018 American Transplant Congress
Program-Specific Transplant Rate Ratios: Association with Allocation Priority at Listing and Posttransplant Outcomes
A. Wey, S. Gustafson, N. Salkowski, J. Pyke, B. Kasiske, A. Israni, J. Snyder.
SRTR, Mineapolis.
The Scientific Registry of Transplant Recipients (SRTR) has updated the transplant rate and waitlist mortality risk-adjustment models to include a wider range of candidate characteristics…
2018 American Transplant Congress
Deceased Pediatric Donor Livers: How Current Policy Drives Allocation and Transplantation
E. Hsu,² J. Ge,¹ J. Bucuvalas,³ J. Lai.¹
¹UC-San Francisco, San Francisco, CA; ²Seattle Children's Hospital, Seattle, WA; ³Cincinnati Children's Hospital, Cincinnati, OH; ⁴University of California San Francisco, San Francisco, CA.
Background:The current liver allocation algorithm for livers from deceased pediatric (<18y; “pedi“) donors prioritizes adults listed locally/regionally over children listed nationally. We sought to understand…
2018 American Transplant Congress
Large Decrease in Liver Waiting List Dropout Rate for MELD > 14
D. Schladt,¹ J. Pyke,¹ A. Israni,¹ W. Kim,² J. Lake,³ J. Snyder.¹
¹SRTR, Minneapolis; ²Stanford University, Stanford; ³Univ of Minnesota, Minneapolis.
Median MELD at transplant has increased steadily over the past 10 years. One possible mechanism is decreased waitlist dropout rates, particularly among liver candidates with…
2018 American Transplant Congress
Biochemistry Profiles Following Pig-to-Nonhuman Primate Liver Xenotransplantation
N. Louras, M. Patel, J. Shah, D. Sachs, P. Vagefi.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Objectives:Clinical progress in liver transplantation has increased the demand for organs, however, supply remains stagnant. Porcine liver xenotransplantation (LXT) would help address this imbalance. Here…
2018 American Transplant Congress
Glycogen Synthase Kinase 3 beta Regulates Liver Inflammation Activation and Resolution by Controlling AMPK Activities
H. Wang,^1,2 M. Ni,^1,2 H. Zhou,² L. Lu,² R. Busuttil,¹ J. Kupiec-Weglinski,¹ Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background & Aims: Glycogen synthase kinase 3β (Gsk3β) is ubiquitously expressed with distinctive functions in different types of cells. Although its roles in regulating innate…