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American Transplant Congress abstracts

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Articles tagged "Liver"

  • 2018 American Transplant Congress

    Differences in Liver Waitlist Mortality Due to Geographic Disparity in Organ Availability

    A. Massie,1 S. DiBrito,1 J. Motter,1 M. Henderson,1 S. Zhou,1 K. Jackson,1 D. Segev,1 S. Gentry.2

    1Johns Hopkins, Baltimore; 2US Naval Academy, Annapolis.

    DSA-level geographic disparity in access to liver transplantation for waitlisted patients has been described, but the impact of this disparity on waitlist mortality is poorly…
  • 2018 American Transplant Congress

    Program-Specific Transplant Rate Ratios: Association with Allocation Priority at Listing and Posttransplant Outcomes

    A. Wey, S. Gustafson, N. Salkowski, J. Pyke, B. Kasiske, A. Israni, J. Snyder.

    SRTR, Mineapolis.

    The Scientific Registry of Transplant Recipients (SRTR) has updated the transplant rate and waitlist mortality risk-adjustment models to include a wider range of candidate characteristics…
  • 2018 American Transplant Congress

    Deceased Pediatric Donor Livers: How Current Policy Drives Allocation and Transplantation

    E. Hsu,2 J. Ge,1 J. Bucuvalas,3 J. Lai.1

    1UC-San Francisco, San Francisco, CA; 2Seattle Children's Hospital, Seattle, WA; 3Cincinnati Children's Hospital, Cincinnati, OH; 4University of California San Francisco, San Francisco, CA.

    Background:The current liver allocation algorithm for livers from deceased pediatric (<18y; “pedi“) donors prioritizes adults listed locally/regionally over children listed nationally. We sought to understand…
  • 2018 American Transplant Congress

    Large Decrease in Liver Waiting List Dropout Rate for MELD > 14

    D. Schladt,1 J. Pyke,1 A. Israni,1 W. Kim,2 J. Lake,3 J. Snyder.1

    1SRTR, Minneapolis; 2Stanford University, Stanford; 3Univ of Minnesota, Minneapolis.

    Median MELD at transplant has increased steadily over the past 10 years. One possible mechanism is decreased waitlist dropout rates, particularly among liver candidates with…
  • 2018 American Transplant Congress

    Biochemistry Profiles Following Pig-to-Nonhuman Primate Liver Xenotransplantation

    N. Louras, M. Patel, J. Shah, D. Sachs, P. Vagefi.

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.

    Objectives:Clinical progress in liver transplantation has increased the demand for organs, however, supply remains stagnant. Porcine liver xenotransplantation (LXT) would help address this imbalance. Here…
  • 2018 American Transplant Congress

    Glycogen Synthase Kinase 3 beta Regulates Liver Inflammation Activation and Resolution by Controlling AMPK Activities

    H. Wang,1,2 M. Ni,1,2 H. Zhou,2 L. Lu,2 R. Busuttil,1 J. Kupiec-Weglinski,1 Y. Zhai.1

    1Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; 2Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

    Background & Aims: Glycogen synthase kinase 3β (Gsk3β) is ubiquitously expressed with distinctive functions in different types of cells. Although its roles in regulating innate…
  • 2018 American Transplant Congress

    Offer Acceptance Practices and Geographic Variability in Allocation MELD at Transplant

    A. Wey,1 S. Gentry,2 J. Pyke,1 D. Schladt,1 T. Weaver,1 N. Salkowski,1 B. Kasiske,1 A. Israni,1 J. Snyder.1

    1SRTR, Minneapolis; 2U.S. Navy, Anapolis.

    Offer acceptance practices may cause geographic variability in allocation model for end-stage liver disease (aMELD) score at transplant and could magnify the apparent impact of…
  • 2018 American Transplant Congress

    A Six-Month, Prospective, Single-Center, Pilot Study to Determine the Pharmacokinetics and Effectiveness of Immunosuppressant Regimens in Liver Transplantation Patients Receiving Twice-Daily Tacrolimus and Everolimus (TAC + EVR BID) Regimen Converted to Once-Daily Tacrolimus and Everolimus (TAC + EVR QD) Regimen – A Priliminary Report

    T-.H. Wu, C-.H. Cheng, Y-.C. Wang, C-.F. Lee, T-.J. Wu, H. Chou, K-.M. Chan, W-.C. Lee.

    Division of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan, Taiwan.

    Adherence to immunosuppressant regimen is crucial for graft survival and usually inversely related to the dose frequency. Similar efficacy and safety profile has been approved…
  • 2018 American Transplant Congress

    PGE2/Beta-Catenin/XBP1 Signaling Controls Mesenchymal Stem Cell-Mediated Immune Regulation in Liver Ischemia and Reperfusion Injury

    C. Li, S. Yue, L. Jiang, Q. Zhu, D. Farmer, R. Busuttil, J. Kupiec-Weglinski, B. Ke.

    The Dumont-UCLA Transplant Center, Department of Surgery, Los Angeles, CA.

    Background: Mesenchymal stem cells (MSCs) display profound immunomodulatory properties and tissue repairing capability under inflammatory conditions. However, it is unknown how MSCs may affect immunity…
  • 2018 American Transplant Congress

    Is Percent Exception at Transplant a Driver of MELD Inflation?

    D. Schladt,1 J. Snyder,1 A. Israni,1 W. Kim,2 J. Lake.3

    1SRTR, Minneapolis, MN; 2Stanford University, Stanford, CA; 3Univ of Minnesota, Minneapolis, MN.

    Before 2016, the proportion of deceased donor liver recipients with an exception status at liver transplant (LT) correlated strongly with median MELD at transplant (MMaT)…
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