Articles tagged "Liver"

2019 American Transplant Congress
The Increasing Financial Challenge of Liver Transplantation
D. Axelrod¹, S. Hohmann², K. Lentine³, H. Xiao³, B. Kasiske⁴, J. Snyder⁴, M. Ostrander⁵, M. Schnitzler³
¹Univ of Iowa, Iowa City, IA, ²Vizient Inc, Chicago, IL, ³Saint Louis Univ, St. Louis, MO, ⁴SRTR, Minneapolis, MN, ⁵Visient, Inc., Minneapolis, IA
*Purpose: Despite innovations in clinical care, liver transplant (LT) remains highly resource intensive due to medical complexity and organ quality. National allocation systems prioritize access…
2019 American Transplant Congress
The Impact of Thrombin / Protease-Activated Receptor-1 Pathway in Hepatic Ischemia-Reperfusion Injury in Mice
D. Noguchi, N. Kuriyama, T. Fujii, H. Kato, M. Kishiwada, S. Mizuno, M. Usui, H. Sakurai, S. Isaji
Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
*Purpose: Coagulation cascade is an important pathway in the pathophysiology of hepatic ischemia-reperfusion injury(IRI). Generation of thrombin is a critical factor of coagulation induced by…
2019 American Transplant Congress
Passive Veno-venous Bypass Instead Of Centrifugal Pump Is Feasible And Low Cost For Experimental Pig Liver Transplant
J. A. Kalil, M. Sanchez-Galvez, M. Hertl, E. Schadde
Surgery, Rush University Medical Center, Chicago, IL
*Purpose: Historically, veno-venous bypass centrifugal pumps are often used to complete OLT; here, we describe a simplified method of passive veno-venous bypass in landrace pigs…
2019 American Transplant Congress
Partial Freezing: Subzero Whole Liver Preservation In The Presence Of Ice
S. E. Cronin¹, C. A. Pendexter¹, R. J. deVries¹, S. Kimura², S. Ozer¹, P. D. Banik¹, S. Nagpal¹, H. Yeh², S. N. Tessier¹, K. Uygun¹, M. Toner¹
¹Center for Engineering in Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ²Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA
*Purpose: We aim to develop a protocol to bank organs for several days, enabling global organ matching and potentially the utilization of organs unusable with…
2019 American Transplant Congress
IgG4 Subclass Class 2 Donor Specific Antibody (DSA) is Associated with Subclinical Rejection in Stable Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests
A. Jackson¹, S. Kanaparthi², B. Burrell³, D. Lucas⁴, R. Vega⁴, A. J. Demetris⁵, S. Feng⁶
¹Surgery, Duke University, Durham, NC, ²The Immune Tolerance Network, Bethesda, MD, ³Immune Tolerance Network, Bethesda, MD, ⁴Medicine, Johns Hopkins University, Baltimore, MD, ⁵Pathology, University of Pittsburgh, Pittsburgh, PA, ⁶Surgery, University of California San Francisco, San Francisco, CA
*Purpose: DSA is a known biomarker of allograft rejection, yet injury phenotype and potential differ across organs. Among pediatric LT recipients entering iWITH (NCT01638559), an…
2019 American Transplant Congress
Use of Marginal Liver Donors in Pediatric Transplantation: Diverse Profiles of Use in Major Transplant Centers
C. S. Hwang¹, A. Aqul², A. Mufti³, S. Hanish¹, D. Desai¹, P. Vagefi¹, M. MacConmara¹
¹Surgery, UT Southwestern, Dallas, TX, ²Pediatrics, UT Southwestern, Dallas, TX, ³Medicine, UT Southwestern, Dallas, TX
*Purpose: Pediatric liver transplantation is highly specialized only a small number of centers have consistent large volume experience. We tested the hypothesis that large volume…
2019 American Transplant Congress
Contribution of CD38 to Methionine Choline Deficient (MCD) Diet-Induced Liver Injury in Rats
J. Kim, Y. Lee, B. F. Reader, C. Akateh, K. R. Maynard, K. W. Washburn, J. L. Zweier, B. A. Whitson, S. M. Black
Department of Cardiac Surgery, The Ohio State Univ. Medical Center, Columbus, OH
*Purpose: Nonalcoholic fatty liver disease (NAFLD) and associated non-alcoholic steatohepatitis (NASH) is a rising cause of end stage liver disease, increasing the need for liver…
2019 American Transplant Congress
Hepatic Artery Anastomosis Post-Operative Anatomy Influences Doppler Ultrasound Systolic Acceleration Time after Liver Transplantation
R. A. Choudhury, A. Yule, K. Conzen, E. A. Pomfret, T. L. Nydam
Transplant Surgery, University of Colorado, Aurora, CO
*Purpose: Prolongation of the systolic acceleration time (SAT) and decreased resistive index (R/I) of the proper hepatic artery following liver transplant have been associated with…
2019 American Transplant Congress
What Do We Not Know about Long Term Liver Transplant Patients? A Look at Side Effect Burden and Medication Adherence
K. Foster¹, C. Perez¹, T. Harrison¹, H. Corbo¹, N. Patel¹, D. Taber¹, H. Meadows¹, J. Fleming¹, D. DuBay², J. McGillicuddy², N. Pilch¹
¹Department of Pharmacy Services, -Medical University of South Carolina, -Charleston, SC, ²Division of Transplant Surgery, Department of Surgery, -Medical University of South Carolina, -Charleston, SC
*Purpose: Historically our focus in transplantation has been on 1 year patient and graft outcomes. With the proposed shifts in legislation and the more recent…
2019 American Transplant Congress
Molecular Analysis of Rejection and Injury in Human Liver Transplant Biopsies: First Results of the INTERLIVER Study
P. F. Halloran and The INTERLIVER Study Group
University of Alberta, Edmonton AB, AB, Canada
*Purpose: The relationship of histologic liver transplant biopsy assessments to actual rejection and injury is unclear. Recent progress in molecular reclassification of kidney, heart, and…