Articles tagged "Liver"

2020 American Transplant Congress
Concurrent Final Acceptance Associated with Decreased Deceased Donor Liver Utilization
A. Robinson¹, K. Shutterly², M. Sellers³, J. Rosendale¹, D. Brockmeier⁴
¹United Network for Organ Sharing, Richmond, VA, ²Center for Organ Recovery and Education, Pittsburgh, PA, ³Emory University Hospital and LifeLink of Georgia, Atlanta, GA, ⁴Mid-America Transplant Services, St. Louis, MO
*Purpose: With broader sharing for candidates with high MELD scores, it is not unusual for liver candidates to receive offers from multiple donors. Accepting multiple…
2020 American Transplant Congress
IM Naltrexone Post Liver Transplant for Alcoholic Hepatitis Patients to Prevent Relapse
A. Flecha
Transplant Surgery, Montefiore Medical Center, Bronx, NY
*Purpose: The number of patients requiring liver transplants due to Hepatitis C Virus is declining due to the new treatment options, and the growing number…
2020 American Transplant Congress
Relative Transplant Center Organ Volumes are Associated with Patient and Graft Survival
J. T. Adler, T. C. Tsai, S. K. Malek, S. G. Tullius, J. S. Weissman
Surgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Transplant programs differ in relative volume of kidney and liver transplants. While there is a known volume-outcome relationship for organ-specific transplantation at an institutional…
2020 American Transplant Congress
Normothermic Ex Vivo Perfusion of Marginal Liver Grafts Rapidly Stimulates Release of Graft-Derived Exosomes and Markedly Decreases the Inflammatory Pathways Induced at Early Times after Transplant Reperfusion
K. E. Brown¹, K. S. Keslar¹, D. Margeta¹, Q. Liu², A. Simioni², L. Del Angel Diaz², W. M. Baldwin¹, R. L. Fairchild¹, C. Quintini²
¹Lerner Research Institute, Cleveland Clinic, Cleveland, OH, ²Transplant Center, Cleveland Clinic, Cleveland, OH
*Purpose: Normothermic ex vivo machine perfusion of liver grafts (EVLP) is emerging as a superior preservation technology to cold storage. Normothermic EVLP transforms a metabolically…
2020 American Transplant Congress
The Liver Protects All? Donor Specific Antibody Formation in Heart-Liver Transplant Recipients
A. W. Rogers¹, T. N. Eagar², C. Pham¹, J. Krisl¹, B. J. Pierce¹, M. Moaddab¹, R. Ghobrial³, B. Trachtenberg⁴, A. Bhimaraj⁴, A. O. Gaber³
¹Department of Pharmacy, Houston Methodist Hospital, Houston, TX, ²Department of Pathology, Houston Methodist Hospital, Houston, TX, ³Department of Surgery, Houston Methodist Hospital, Houston, TX, ⁴Houston Methodist Hospital, Houston, TX
*Purpose: Donor specific antibodies (DSAs) are key in the development of antibody mediated rejection (AMR). Their role in decreased patient and graft survival has been…
2020 American Transplant Congress
Humanized Mouse Reveals the Cytoprotective Function of Hepatocyte RXFP1 in Liver Transplant Recipients
H. Kojima¹, S. Kageyama¹, K. Kadono¹, H. Hirao¹, K. J. Dery¹, T. Ito¹, G. Sugahara², Y. Ishida², T. Saito², F. M. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec-Weglinski¹
¹Surgery, The Dumont-UCLA Transplantation Center, Los Angeles, CA, ²Division of Gastrointestinal and Liver Disease, Keck School of Medicine, USC, Los Angeles, CA
*Purpose: RXFP1 (RLX family peptide receptor 1) is a cognate receptor for relaxin (RLX), an insulin-like growth factor, with vasoactive/remodeling properties. We have documented cytoprotective…
2020 American Transplant Congress
Machine Learning to Predict Deceased Donor Liver Biopsy Results
C. Martinez, A. Placona
United Network for Organ Sharing, Richmond, VA
*Purpose: Biopsies are often cited as a key factor on whether to accept a deceased liver offer. Motivated by the influential role of biopsy findings…
2020 American Transplant Congress
Effect of Pre-Transplant Opioid Use on Post Liver Transplant Outcomes
K. Guilbert, H. Underwood, C. J. Simon
Lahey Hospital and Medical Center, Burlington, MA
*Purpose: Impact of pre-liver transplant opioid use on post-liver transplant length of stay and clinical outcomes.*Methods: This single-institution retrospective study included adult patients who received…
2020 American Transplant Congress
An Early Look at the National Liver Review Board
S. Noreen¹, R. Hirose², J. Trotter³, J. Heimbach⁴
¹United Network for Organ Sharing, Richmond, VA, ²University of California - San Francisco, San Francisco, CA, ³Texas Digestive Disease Consultants, Dallas, TX, ⁴Mayo Clinic, Rochester, MN
*Purpose: On May 14, 2019, the National Liver Review Board (NLRB) was implemented, establishing a national structure for liver exceptions comprised of three specialty review…
2020 American Transplant Congress
Hepatic Microenvironment: Molecular and Chemical Changes Associated with Preconditioning Maneuvers
I. Lies, C. Watkins, M. Em, J. D. Eason, C. Eynard, T. Rousselle, V. R. Mas, D. Maluf
Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Liver preconditioning has been described to protect liver from ischemia injury and trigger liver regeneration. Hereby, we aimed to assess the effect of preconditioning…