Articles tagged "Liver transplantation"

2019 American Transplant Congress
Evaluating Liver Regeneration during Normothermic Machine Perfusion in Hepatectomized Rat Liver Model
M. Aburawi¹, S. Mert¹, E. Hafiz², P. Mahboub¹, H. Yeh¹, K. Uygun¹, J. Markmann¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Pathology and Electron Microscopy, Theodor Bilharz Research Institute, Cairo, Egypt
*Purpose: Realizing the liver’s unique ability to regenerate, this ongoing study examines Normothermic Machine Perfusion (NMP) as a promising platform for evaluating & potentially simulating…
2019 American Transplant Congress
Outcomes of Liver Transplantation for Mixed Hepatocellular-Cholangiocarcioma
M. Najjar¹, K. Bruestle¹, P. Jiang¹, S. Robbins-Juarez¹, R. Hwang¹, A. Mathur¹, E. C. Verna¹, A. Griesemer¹, B. Samstein¹, T. Kato¹, Y. M. Saenger¹, K. J. Halazun², J. C. Emond¹
¹Columbia University Medical Center, New York, NY, ²Weill Cornell Medicine, New York, NY
*Purpose: Mixed hepatocholangiocarcinomas (HCC-CCA) are rare tumors with both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) differentiations. They are usually associated with a worse prognosis than…
2019 American Transplant Congress
HOPE in Action: A Multicenter Prospective Study of HIV to HIV Liver Transplantation
C. Durand¹, S. Florman², M. Bowring³, D. Brown¹, B. Haydel², J. Hamilton¹, P. Stock⁴, J. Price⁵, T. Pruett⁶, V. Kirchner⁷, D. Wojciechowksi⁸, N. Turgeon⁹, C. Wolfe¹⁰, V. Stosor¹¹, J. Charette¹¹, A. Cameron³, S. Ottmann³, S. Huprikar¹², D. Segev³
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Surgery, Mount Sinai, New York, NY, ³Surgery, Johns Hopkins University, Baltimore, MD, ⁴Surgery, University of California San Francisco, San Francisco, CA, ⁵Medicine, University of California San Francisco, San Francisco, CA, ⁶Surgery, University of Minnesota, Minneapolis, MN, ⁷Medicine, University of Minnesota, Minneapolis, MN, ⁸Medicine, Mass General Hospital, Boston, MA, ⁹Surgery, Emory University, Atlanta, GA, ¹⁰Medicine, Duke University, Durham, NC, ¹¹Medicine, Northwestern University, Chicago, IL, ¹²Medicine, Mount Sinai, New York, NY
*Purpose: HIV+ liver transplant (LT) candidates face higher mortality and lower access to transplant compared to HIV- counterparts. With the US HOPE Act, HIV+ donor…
2019 American Transplant Congress
A Randomized, Controlled, Trial of Interventions to Promote Walking after Abdominal Organ Transplantation: The LIFT Study
M. Serper¹, I. Barankay², S. Chadha¹, J. Shults³, P. Reese¹
¹University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Wharton School, University of Pennsylvania, Philadelphia, PA, ³Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA
*Purpose: Substantial weight gain and sedentary behavior are common after transplantation. Behavioral economic strategies with financial incentives and reminders may promote healthy behaviors in the…
2019 American Transplant Congress
Loss of FXR Exacerbates Liver Damage by Activating NLRP3 Inflammasome Induced Pyroptosis in Liver Ischemia Reperfusion Injury
Z. Zhu, Y. Zhang, Y. Tang, S. Huang, Q. Zhao, W. Ju, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: The relationships among Farnesoid X receptor (FXR), nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome and pyroptosis are largely unknown in…
2019 American Transplant Congress
Risk Stratification of Patients Undergoing Simultaneous Liver Transplantation and Cardiac Surgery
T. Diago Uso, G. D'Amico, S. Armanyous, L. Lomaglio, B. Eghtesad, M. Fujiki, F. Aucejo, K. Sasaki, N. K. Menon, M. Fares, M. Tong, K. Hashimoto, C. Miller, C. Quintini
Cleveland Clinic, Cleveland, OH
*Purpose: Evaluate risk factors and outcomes of combined liver transplantation (OLT) and cardiac surgery, including coronary artery grafting and valve replacement.*Methods: Between 1/2005 and 8/2018,…
2019 American Transplant Congress
Evaluation of Liver Transplantation among Advanced Age Recipients in a Large Multicenter U.S. Cohort
A. Goel¹, A. Kwong², D. Devuni³, C. Wang², J. Boike⁴, J. Jo⁴, L. VanWagner⁴, M. Serper⁵, L. Jones⁵, R. Sharma⁶, E. Verna⁶, J. Shor³, M. German⁷, A. Hristov⁷, A. Lee⁷, E. Spengler⁷, A. Koteish⁸, G. Sehmbey⁹, A. Seetharam⁹, N. John¹, Y. Patel¹⁰, M. Kappus¹⁰, T. Couri¹¹, R. Salgia¹², Q. Nhu¹³, C. Frenette¹³, J. Lai²
¹Stanford University, Palo Alto, CA, ²University of California, San Francisco, CA, ³University of Massachusetts, Worcester, MA, ⁴Northwestern, Chicago, IL, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Columbia University, New York, NY, ⁷University of Wisconsin, Madison, WI, ⁸Florida Hospital, Orlando, FL, ⁹University of Arizona, Phoenix, AZ, ¹⁰Duke University, Durham, NC, ¹¹University of Chicago, Chicago, IL, ¹²Henry Ford Hospital, Detroid, MI, ¹³Scripps, San Diego, CA
*Purpose: The proportion of adults ≥70 years (y) listed for liver transplant (LT) in the U.S. is rising. Outcomes in this growing population are limited…
2019 American Transplant Congress
Sequestration of PLIN2 Regulates High-Fat Diet Induced Metabolic Syndrome and Nonalcoholic Fatty Liver Disease in a Mouse Model of Ischemia Reperfusion Injury
K. Loh¹, X. Liu¹, L. Belyayev¹, C. Albanese², W. Cui¹, T. M. Fishbein¹, K. M. Khan¹, A. Kroemer¹
¹Transplant, MedStar Georgetown Transplant Institute, Washington, DC, ²Oncology, Georgetown University, Washington, DC
*Purpose: This study aimed to define characteristics and mechanisms leading to nonalcoholic fatty liver disease and metabolic syndrome in a fatty liver mouse model that…
2019 American Transplant Congress
Transplant Provider Adherence to Cardiovascular Disease Primary Prevention Guidelines in Liver Transplant Recipients
M. Kosirog¹, P. T. Campbell¹, S. Montag², S. Connolly¹, A. Daud³, A. Das¹, S. Pine¹, D. Finn³, J. Levitsky¹, J. L. Holl⁴, D. M. Lloyd-Jones⁵, L. B. VanWagner⁶
¹Division of GI and Hepatology, Department of Medicine, Northwestern Medicine, Chicago, IL, ²Department of Preventative Medicine, Northwestern Medicine, Chicago, IL, ³Center for Healthcare Studies, Northwestern Medicine, Chicago, IL, ⁴Department of Pediatrics and Center for Healthcare Studies, Northwestern Medicine, Chicago, IL, ⁵Department of Preventive Medicine and Division of Cardiology, Department of Medicine, Northwestern Medicine, Chicago, IL, ⁶Division of GI and Hepatology, Department of Medicine and Department of Preventive Medicine, Northwestern Medicine, Chicago, IL
*Purpose: Blood pressure (BP) control, aspirin, and statin use are modifiable risk factors for primary prevention of atherosclerotic cardiovascular disease (ASCVD), stroke, and heart failure…
2019 American Transplant Congress
Clinical Outcomes of Living versus Deceased Donor Liver Transplantation for Primary Sclerosing Cholangitis: A Multicenter 15 Year Experience
O. Y. Mousa¹, K. D. Watt¹, J. K. Heimbach², A. P. Keaveny³, J. E. Eaton¹, D. M. Harnois³, B. Taner³, E. J. Carey⁴, A. A. Moss⁴, C. B. Rosen⁵, T. Taner⁵
¹Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, ²Department of Surgery, Mayo Clinic, Rochester, MN, ³Department of Transplant, Mayo Clinic, Jacksonville, FL, ⁴Department of Transplant, Mayo Clinic, Scottsdale, AZ, ⁵Department of Transplant, Mayo Clinic, Rochester, MN
*Purpose: MELD-based allocation is known to reduce access to deceased donor liver transplantation (DDLT) for patients with primary sclerosing cholangitis (PSC). Living donor liver transplantation(LDLT)…