Articles tagged "Liver transplantation"

2019 American Transplant Congress
The Role of Non-Traditional Environmental Factors in Long-Term Outcomes of Liver Transplantation
J. Buggs¹, D. Patino², B. Evans¹, C. Anderson¹, C. Delfavero¹, E. Rogers¹, A. Alsina¹, A. Kumar³
¹Tampa General Hospital, Tampa, FL, ²University of Tampa, Tampa, FL, ³University of South Florida, Tampa, FL
*Purpose: The purpose of this research project was to evaluate the role of non-traditional subjective environmental factors in long-term outcomes of liver transplantation.*Methods: We conducted…
2019 American Transplant Congress
Lifelong Immunosuppression, I Am Sure We Told Them That?: Long Term Medication Adherence in Liver Transplant Patients
K. Foster¹, C. Perez¹, T. Harrison¹, H. Corbo¹, N. Patel¹, J. Fleming¹, H. Meadows¹, D. Taber¹, D. DuBay², J. McGillicuddy², N. Pilch¹
¹Department of Pharmacy Services, -Medical University of South Carolina, -Charleston, SC, ²Division of Transplant Surgery, Department of Surgery, -Medical University of South Carolina, -Charleston, SC
*Purpose: Current literature describes demographic information of non-adherent patients and identifies that non-adherence may be predictive of post-txp outcomes. We suspect that patients with private…
2019 American Transplant Congress
Costimulatory Blockade and Allo-Specific Treg Therapy for Liver Transplant Recipients: Preclinical Data
L. Contreras-Ruiz¹, K. Shimozawa², R. Zhang¹, L. Turka³, J. F. Markmann³, E. C. Guinan²
¹Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, ²Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, ³Center of Transplantation Sciences, Massachussetts General Hosp., Boston, MA
*Purpose: Adoptive transfer of ex vivo generated donor-specific regulatory T cells (Treg) by using CD28/B7 costimulatory blockade (CSB) to induce transplant (TX) tolerance and minimize…
2019 American Transplant Congress
Discovery and Validation of an Early Post-Transplant Biomarker Model Predictive of Chronic Kidney Disease in Liver Transplant Recipients
J. Levitsky¹, S. Asrani², G. Klintmalm², T. Schiano², A. Moss³, K. Chavin⁴, C. Miller⁵, L. Zhao⁶, K. Guo⁶, N. Bridges⁷, J. Odim⁷, M. Brown⁷, D. Ikle⁸, B. Armstrong⁸, M. Abecassis⁹
¹Gastroenterology and Hepatology, Northwestern University, Chicago, IL, ²Baylor, Dallas, TX, ³Mayo Arizona, Phoenix, AZ, ⁴Case Western, Cleveland, OH, ⁵Cleveland Clinic, Cleveland, OH, ⁶Northwestern University, Chicago, IL, ⁷NIAID, Bethesda, MD, ⁸Rho, Chapel Hill, NC, ⁹Comprehensive Transplant Center, Northwestern University, Chicago, IL
*Purpose: A significant proportion of patients develop chronic kidney disease after liver transplantation (LT). We aimed to develop clinical/protein models to predict future GFR deterioration…
2019 American Transplant Congress
Hepatocyte SIRT1 Modulates ATF4/CHOP and Mitigates Liver Transplant Ischemia-Reperfusion Injury: From Bench-to-Bedside
H. Hirao¹, S. Kageyama¹, K. Kadono¹, K. Nakamura¹, T. Ito¹, K. J. Dery¹, D. Oncel¹, X. Li², B. Ke¹, F. M. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec‐Weglinski¹
¹Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA, ²National Institute of Environmental Health Sciences, Research Triangle Park, NC
*Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation against hepatic ischemia-reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Although…
2019 American Transplant Congress
The Comparative Safety and Efficacy of Direct Acting Oral Anticoagulants Relative to Warfarin Following Liver Transplantation
A. Santeusanio, A. Weinberg, T. Schiano
Mount Sinai Hospital, New York, NY
*Purpose: This study describes the comparative safety and efficacy of direct acting oral anticoagulants (DOACs) relative to warfarin following liver transplantation, at a large academic…
2019 American Transplant Congress
Impact of Coronary Artery Disease on Long-Term Mortality after Liver Transplantation
S. S. Patel¹, V. A. Rodriguez², M. B. Siddiqui¹, J. Laurenzano³, F. Lin³, J. Clinton³, M. Faridnia⁴, A. Chandrakumaran⁴, T. Reichman⁵, C. Bhati⁵, M. S. Siddiqui¹
¹Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, ²Department of Bio-statistics, Virginia Commonwealth University, Richmond, VA, ³Virginia Commonwealth University, Richmond, VA, ⁴Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, ⁵Department of Transplant Surgery, Virginia Commonwealth University, Richmond, VA
*Purpose: Cardiovascular disease (CVD) is an important cause of post liver transplantation (LT) mortality and is higher than age-and gender matched cohorts. This happens despite…
2019 American Transplant Congress
Impact of Recipient Age in Combined Liver-Kidney Transplantation (CLKT): Caution is Needed for Elderly Patients≥70 Years
B. Ekser¹, W. C. Goggins¹, R. S. Mangus¹, P. Mihaylov¹, J. A. Fridell¹, M. A. Lacerda², M. S. Ghabril², J. A. Powelson¹, C. A. Kubal¹
¹Transplant Division, Department of Surgery, Indiana University, Indianapolis, IN, ²Gastroenterology, Indiana University, Indianapolis, IN
*Purpose: Recent SRTR analysis showed that elderly recipients (≥70 years) accounts for 2.6% of all liver transplant alone (LTA) and do as well as younger…
2019 American Transplant Congress
Effectiveness Of The Vittal Viability Criteria During Ex Situ Normothermic Machine Perfusion To Discriminate Hepatobiliary Organ Injury And Investigation Of Biochemical Markers For Post-transplant Complications
Y. L. Boteon, R. Laing, J. Attard, L. Wallace, A. Smith, M. Perera, D. Mirza, H. Mergental, S. Afford
Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom
*Purpose: The VITTAL (viability testing and transplantation of marginal livers) clinical trial demonstrated that ex situ end-ischaemic normothermic machine perfusion (NMP) allows functional assessment and…
2019 American Transplant Congress
Comparable Outcomes of Deceased Donor Liver Transplant Outcomes in Recipients with Previous Abdominal Surgery (PAS) after Pre Listing Surgical Categorization. A Propensity-Score Matched Pair Analysis
H. Sharma, H. Bohorquez, D. Oganesyan, D. Bruce, E. Bugeaud, I. Carmody, A. Cohen, J. Seal, D. Sonnier, G. Loss
Department of Transplant Surgery, Ochsner Medical Center, New Orleans, LA
*Purpose: Few studies have evaluated the impact of previous abdominal surgery (PAS) on deceased donor liver transplantation-(DDLT). Furthermore, there is no evidence of impact of…