Articles tagged "Liver transplantation"

2019 American Transplant Congress
Paradoxical Liver Simulated Allocation Model (LSAM) Projections for Changes to Waitlist Mortality under Acuity Circle Distribution Model
R. Lynch¹, K. Ross¹, S. Karp²
¹Emory, Atlanta, GA, ²Vanderbilt, Nashville, TN
*Purpose: In December 2018, the United Network for Organ Sharing (UNOS) board voted to change liver transplant distribution from Donor Service Areas (DSAs) to a…
2019 American Transplant Congress
Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes
J. Attard¹, W. Dunn², L. Wallace¹, R. Laing¹, Y. Boteon¹, H. Mergental³, D. Mirza³, T. Perera³, S. Afford¹
¹CLGR, University of Birmingham and NIHR Biomedical Research Centre, Birmingham, United Kingdom, ²Phenome Centre Birmingham, University of Birmingham, Birmingham, United Kingdom, ³Liver Unit, Queen Elizabeth University Hospital, Birmingham, United Kingdom
*Purpose: Donor organ shortage has led to increased reliance on high-risk livers for transplantation. Furthermore, emergence of machine perfusion has led to a paradigm shift…
2019 American Transplant Congress
Sustained Biologic Response To Neoadjuvant Therapy Predicts Excellent Liver Transplant Outcomes For Locally Advanced Intrahepatic Cholangiocarcinoma
K. E. Lunsford¹, M. Javle², K. Heyne³, R. A. Ali², C. M. Mobley¹, A. Saharia¹, D. W. Victor¹, M. J. Hobeika¹, A. Kasab², R. S. McFadden¹, T. A. Aloia², X. C. Li¹, H. P. Monsour¹, A. O. Gaber¹, A. O. Gaber¹, J. Vauthey², R. M. Ghobrial¹
¹J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX, ²The University of Texas MD Anderson Cancer Center, Houston, TX, ³Department of Oncology, Houston Methodist Hospital, Houston, TX
*Purpose: Intrahepatic cholangiocarcinoma (iCCA) is a contraindication for liver transplant (LT), but prior studies limited evaluation to incidental iCCA. We recently reported significant improvement in…
2019 American Transplant Congress
Expanding the Donor Pool with Extended Criteria DCD Livers
P. Mihaylov¹, B. Ekser², R. Mangus², J. Fridell², D. Soma², C. Kubal²
¹Indiana Univ School of Medicine, Pavia Univ School of Medicine, Indianapolis, IN, ²Indiana Univ School of Medicine, Indianapolis, IN
*Purpose: Utilization of extended criteria donation after circulatory death (ECD DCD) livers has remained cautious due to potentially worse outcomes because of higher rates of…
2019 American Transplant Congress
Renal Recovery and Prognostic Factors in Children Following Liver Transplantation
R. Büscher, N. Gantenberg, A. Büscher, E. Lainka, P. Hoyer
Department of Pediatrics II, University Hospital Essen, Essen, Germany
*Purpose: Progression to chronic renal disease (CKD) is highly prevalent in adults following liver transplantation (LT) with a profound impact on patient survival, assuming that…
2019 American Transplant Congress
Treg Plasticity is Induced by ENV,HERV1_I and UPR Activation in De Novo Autoimmune Hepatitis
J. Yao¹, A. Ling¹, A. Arterbery¹, Y. Avitzur², S. Lobritto³, M. Martinez³, U. Ekong¹
¹Yale University, New Haven, CT, ²University of Toronto, Toronto, ON, Canada, ³Columbia University, New York, NY
*Purpose: FOXP3+regulatory T cells (Tregs) are not a terminally differentiated population & can, under specific environmental conditions, acquire the phenotype of effector T cells. We…
2019 American Transplant Congress
Combined Liver and Delayed Kidney Transplantation (CLKT) Enables Similar Patient Survival as Liver Transplantation Alone (LTA): Propensity Score-Based Comparison
B. Ekser¹, C. A. Kubal¹, R. S. Mangus¹, P. Mihaylov¹, J. A. Fridell¹, L. R. Timsina¹, M. Lacerda², M. Ghabril², J. A. Powelson¹, W. C. Goggins¹
¹Transplant Division - Department of Surgery - Indiana University, Indianapolis, IN, ²Gastroenterology, Indiana University, Indianapolis, IN
*Purpose: We previously showed the positive impact of delayed KT in CLKT on patient survival compared to simultaneous KT. It is well known from the…
2019 American Transplant Congress
The Liver Frailty Index is Associated with Current and Subsequent Disability in Liver Transplant Candidates
J. C. Lai, J. L. Dodge, C. E. McCulloch, K. E. Covinsky, J. P. Singer
University of California, San Francisco, San Francisco, CA
*Purpose: The Liver Frailty Index (LFI) was developed to capture the effects of malnutrition and muscle wasting in patients with cirrhosis awaiting liver transplantation (LT).…
2019 American Transplant Congress
Ischemia-Free Liver Transplantation Protects Bile Duct from Ischemia/Reperfusion Injury
J. Yang, S. Huang, Z. Zhang, Q. Zhao, W. Ju, Z. Zhu, Y. Tang, L. Wang, Y. Zhang, C. Sun, L. Wu, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Ischemia-free liver transplantation (IFLT), based on normothermic machine perfusion and innovations in surgical technique, can provide continue blood supply from procurement to implantation that…
2019 American Transplant Congress
Patients With Biliary Complications Following Orthotopic Liver Transplantation Can Be Successfully Managed By Serial Endoscopic Retrograde Cholangio-pancreatography
R. Kaur, I. C. Morales, D. Dhillon, M. S. Ilias, S. Nagai, D. Venkat, A. Yoshida, S. Jafri
Henry Ford Hospital, Detroit, MI
*Purpose: We evaluated the quality of endoscopic intervention for biliary complications after liver transplantation in a diverse urban center.*Methods: A retrospective chart review of liver…