Articles tagged "Liver transplantation"

2020 American Transplant Congress
Living versus Deceased Donor Liver Transplantation in Cholestatic Liver Disease: An Analysis of the OPTN Database
I. A. Ziogas¹, S. P. Alexopoulos¹, L. K. Matsuoka¹, S. K. Geevarghese¹, L. D. Gorden¹, S. J. Karp¹, J. D. Perkins², M. I. Montenovo¹
¹Vanderbilt University Medical Center, Nashville, TN, ²University of Washington, Seattle, WA
*Purpose: The current MELD allocation system does not accurately reflect the urgency of liver transplantation (LT) in cholestatic liver disease (CLD) patients. Therefore, more CLD…
2020 American Transplant Congress
Hypernatremia Predicts Waitlist Death and Deterioration, but Not Post-Transplant Outcomes in Pediatric Liver Transplant Candidates
L. Thalji¹, N. Thalji², S. Ibrahim³, J. Heimbach², P. Kamath⁴, D. Haile¹, D. Kor¹
¹Anesthesiology, Mayo Clinic, Rochester, MN, ²Surgery, Mayo Clinic, Rochester, MN, ³Pediatric Gastroenterology, Mayo Clinic, Rochester, MN, ⁴Gastroenterology, Mayo Clinic, Rochester, MN
*Purpose: Pre-transplant hypernatremia has been shown to predict post-transplant mortality in adult liver transplant (LT) recipients. The effects of hypernatremia in children, however, remain unexplored.…
2020 American Transplant Congress
Characterization of a Clinically Scaled Bioengineered Liver Seeded with Primary Hepatocytes and Endothelial Cells
D. S. Davidow¹, J. J. Ross¹, B. D. Anderson¹, A. Stumbras¹, A. A. Katane¹, R. Lindeman¹, B. G. Steiner¹, A. Mendenhall¹, K. Gahlbeck¹, S. Armstrong¹, B. P. Amiot², E. D. Nelson², T. Gilbert¹, S. L. Nyberg²
¹Miromatrix, Eden Prairie, MN, ²Mayo Clinic, Rochester, MN
*Purpose: Advancements in whole organ bioengineering have the potential to offer solutions to a chronically insufficient donor organ supply. We recently demonstrated an ability to…
2019 American Transplant Congress
Evaluating Liver Regeneration during Normothermic Machine Perfusion in Hepatectomized Rat Liver Model
M. Aburawi¹, S. Mert¹, E. Hafiz², P. Mahboub¹, H. Yeh¹, K. Uygun¹, J. Markmann¹
¹Surgery, Massachusetts General Hospital, Boston, MA, ²Pathology and Electron Microscopy, Theodor Bilharz Research Institute, Cairo, Egypt
*Purpose: Realizing the liver’s unique ability to regenerate, this ongoing study examines Normothermic Machine Perfusion (NMP) as a promising platform for evaluating & potentially simulating…
2019 American Transplant Congress
Outcomes of Liver Transplantation for Mixed Hepatocellular-Cholangiocarcioma
M. Najjar¹, K. Bruestle¹, P. Jiang¹, S. Robbins-Juarez¹, R. Hwang¹, A. Mathur¹, E. C. Verna¹, A. Griesemer¹, B. Samstein¹, T. Kato¹, Y. M. Saenger¹, K. J. Halazun², J. C. Emond¹
¹Columbia University Medical Center, New York, NY, ²Weill Cornell Medicine, New York, NY
*Purpose: Mixed hepatocholangiocarcinomas (HCC-CCA) are rare tumors with both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) differentiations. They are usually associated with a worse prognosis than…
2019 American Transplant Congress
HOPE in Action: A Multicenter Prospective Study of HIV to HIV Liver Transplantation
C. Durand¹, S. Florman², M. Bowring³, D. Brown¹, B. Haydel², J. Hamilton¹, P. Stock⁴, J. Price⁵, T. Pruett⁶, V. Kirchner⁷, D. Wojciechowksi⁸, N. Turgeon⁹, C. Wolfe¹⁰, V. Stosor¹¹, J. Charette¹¹, A. Cameron³, S. Ottmann³, S. Huprikar¹², D. Segev³
¹Medicine, Johns Hopkins University, Baltimore, MD, ²Surgery, Mount Sinai, New York, NY, ³Surgery, Johns Hopkins University, Baltimore, MD, ⁴Surgery, University of California San Francisco, San Francisco, CA, ⁵Medicine, University of California San Francisco, San Francisco, CA, ⁶Surgery, University of Minnesota, Minneapolis, MN, ⁷Medicine, University of Minnesota, Minneapolis, MN, ⁸Medicine, Mass General Hospital, Boston, MA, ⁹Surgery, Emory University, Atlanta, GA, ¹⁰Medicine, Duke University, Durham, NC, ¹¹Medicine, Northwestern University, Chicago, IL, ¹²Medicine, Mount Sinai, New York, NY
*Purpose: HIV+ liver transplant (LT) candidates face higher mortality and lower access to transplant compared to HIV- counterparts. With the US HOPE Act, HIV+ donor…
2019 American Transplant Congress
A Randomized, Controlled, Trial of Interventions to Promote Walking after Abdominal Organ Transplantation: The LIFT Study
M. Serper¹, I. Barankay², S. Chadha¹, J. Shults³, P. Reese¹
¹University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Wharton School, University of Pennsylvania, Philadelphia, PA, ³Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA
*Purpose: Substantial weight gain and sedentary behavior are common after transplantation. Behavioral economic strategies with financial incentives and reminders may promote healthy behaviors in the…
2019 American Transplant Congress
Loss of FXR Exacerbates Liver Damage by Activating NLRP3 Inflammasome Induced Pyroptosis in Liver Ischemia Reperfusion Injury
Z. Zhu, Y. Zhang, Y. Tang, S. Huang, Q. Zhao, W. Ju, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: The relationships among Farnesoid X receptor (FXR), nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome and pyroptosis are largely unknown in…
2019 American Transplant Congress
Risk Stratification of Patients Undergoing Simultaneous Liver Transplantation and Cardiac Surgery
T. Diago Uso, G. D'Amico, S. Armanyous, L. Lomaglio, B. Eghtesad, M. Fujiki, F. Aucejo, K. Sasaki, N. K. Menon, M. Fares, M. Tong, K. Hashimoto, C. Miller, C. Quintini
Cleveland Clinic, Cleveland, OH
*Purpose: Evaluate risk factors and outcomes of combined liver transplantation (OLT) and cardiac surgery, including coronary artery grafting and valve replacement.*Methods: Between 1/2005 and 8/2018,…
2019 American Transplant Congress
Evaluation of Liver Transplantation among Advanced Age Recipients in a Large Multicenter U.S. Cohort
A. Goel¹, A. Kwong², D. Devuni³, C. Wang², J. Boike⁴, J. Jo⁴, L. VanWagner⁴, M. Serper⁵, L. Jones⁵, R. Sharma⁶, E. Verna⁶, J. Shor³, M. German⁷, A. Hristov⁷, A. Lee⁷, E. Spengler⁷, A. Koteish⁸, G. Sehmbey⁹, A. Seetharam⁹, N. John¹, Y. Patel¹⁰, M. Kappus¹⁰, T. Couri¹¹, R. Salgia¹², Q. Nhu¹³, C. Frenette¹³, J. Lai²
¹Stanford University, Palo Alto, CA, ²University of California, San Francisco, CA, ³University of Massachusetts, Worcester, MA, ⁴Northwestern, Chicago, IL, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Columbia University, New York, NY, ⁷University of Wisconsin, Madison, WI, ⁸Florida Hospital, Orlando, FL, ⁹University of Arizona, Phoenix, AZ, ¹⁰Duke University, Durham, NC, ¹¹University of Chicago, Chicago, IL, ¹²Henry Ford Hospital, Detroid, MI, ¹³Scripps, San Diego, CA
*Purpose: The proportion of adults ≥70 years (y) listed for liver transplant (LT) in the U.S. is rising. Outcomes in this growing population are limited…