Articles tagged "Liver transplantation"

2021 American Transplant Congress
Impact of Donation After Circulatory Death Donor Allografts on Outcomes Following Liver Transplantation for Cholangiocarcinoma
S. Kumar¹, S. Lin², J. D. Schold²
¹Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, ²Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Improvements in the management of extra-hepatic cholangiocarcinoma (CCA) resulted in allocation of a standardized model for end-stage liver disease (MELD) exception score for liver…
2021 American Transplant Congress
Waitlist Outcomes for Exception Candidates Following the Implementation of MMaT/250 Score
T. Ishaque¹, J. G. Wang¹, S. Karhadkar², D. Segev¹, A. B. Massie¹
¹Johns Hopkins Medical Institutions, Baltimore, MD, ²Temple University, Philadelphia, PA
*Purpose: Starting in May 2019, exception points were allocated based on DSA-level median-MELD-at-transplant (MMaT/DSA). In February 2020, the exception point system was further modified based…
2021 American Transplant Congress
Comparison of Outcomes of Living Donor Liver Transplantation for Biliary Atresia Patients with and without Kasai Portoenterostomy
T. Kanmaz¹, O. Andacoglu¹, Y. Yankol², C. Karatas¹, N. Mecit¹, K. Acarli³, M. Kalayoglu¹
¹Koc University, Istanbul, Turkey, ²University of Wisconsin, Madison, WI, ³Memorial Hospital, Istanbul, Turkey
*Purpose: We evaluated 10 year outcomes and the potential predictors of outcomes after living donor liver transplant (LT) for biliary atresia (BA) patients with and…
2021 American Transplant Congress
Validation of a Novel Gene Expression Biomarker of Rejection Following Liver Transplantation
J. Levitsky¹, M. Kandpal¹, T. Whisenant², K. Guo¹, S. Kurian³, M. Abecassis⁴
¹Gastroenterology & Hepatology; Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²University of California San Diego, San Diego, CA, ³Scripps Clinic, La Jolla, CA, ⁴University of Arizona College of Medicine Tucson, Tucson, AZ
*Purpose: Non-invasive biomarkers distinguishing early signs of immune activation vs. quiescence could more objectively guide immunosuppression management after liver transplantation (LT). Our aim was to…
2020 American Transplant Congress
Increasing Prevalence and Diversity: Alcoholic Liver Disease in Liver Transplant Candidates
M. Joshi, E. L. Godfrey, J. A. Goss, A. Rana
Baylor College of Medicine, Houston, TX
*Purpose: Increasing global alcohol use translates to a marked growth in alcoholic liver disease (ALD). ALD patients comprise a larger proportion of listings for liver…
2020 American Transplant Congress
Cirrhosis-Driven Immune Dysfunction is Associated with Poor Response to DEB-TACE and Waitlist Dropout in Hepatocellular Carcinoma Patients While Awaiting Liver Transplantation
K. Nunez, T. Sandow, M. Hibino, A. Cohen, P. Thevenot
Ochsner Health System, New Orleans, LA
*Purpose: Hepatocellular carcinoma (HCC) recurrence after transplantation is associated with higher tumor grade on explant, failure to respond to DEB-TACE, and pretreatment lymphopenia. We prospectively…
2020 American Transplant Congress
TIM-4+ Kupffer Cells Play Homeostatic Roles in Liver Ischemia Reperfusion Injury
M. Ni¹, J. Zhang¹, R. Sosa², S. Kageyama¹, R. Busuttil¹, R. Elaine², J. Kupiec-Weglinski¹, X. Wang³, Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Pathology, David Geffen School of Medicine-UCLA, Los Angeles, CA, ³Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Liver ischemia reperfusion injury (IRI) remains a significant clinical problem. Although the molecular mechanism of liver inflammatory response against IR has been studied extensively,…
2020 American Transplant Congress
Biliary Reconstructionwith High Biliary Radicals is Safe Option for Multiple Graft Bile Ducts in Right Lobe Living Donor Liver Transplantation
J. Kim, D. Choi, E. Jwa
Department of Surgery, Catholic University of Daegu College of Medicine, Daegu, Korea, Republic of
*Purpose: Multiple small size donor bile ducts (BDs) are related to higher incidence of biliary complications (BCs) and biliary reconstruction for multiple BDs still remains…
2020 American Transplant Congress
The Efficacy and Safety of Ischemia-Free Liver Transplantation (IFLT) in the Treatment of End-Stage Liver Disease in a Prospective, Randomized, Controlled Trial: A Report of the First 25 Cases
X. He, Z. Guo, Q. Zhao, C. Huang, W. Ju, D. Wang, M. Chen, L. Wu, Y. Ma, Y. Chen, A. Hu, X. Zhu
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: We’ve established a novel procedure called ischemia-free liver transplantation (IFLT). The results from the pilot study suggest that IFLT might prevent ischemia-reperfusion injury (IRI)…
2020 American Transplant Congress
Pre-Transplant Overt Hepatic Encephalopathy is Associated with Greater Cognitive Improvement after Liver Transplant
M. Kim¹, J. Menzel-Smith¹, J. D. Peipert², K. J. Reid¹, P. Zee¹, D. P. Ladner³
¹Neurology, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL, ³Surgery, Northwestern University, Chicago, IL
*Purpose: Persistent or residual cognitive impairment following liver transplant is frequently reported yet not well-characterized.*Methods: Cognitive function was tested in a prospective cohort of patients…