Articles tagged "Liver transplantation"

2021 American Transplant Congress
Geographic Divergence in Waitlist Registration and Trends in Waitlist Removal for Liver Transplantation in Patients with Nonalcoholic Steatohepatitis (NASH)
C. Hanlon¹, B. Saberi², L. Yuan¹
¹Internal Medicine - Transplant Hepatology, University of Southern California, Los Angeles, CA, ²Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: This study aims to evaluate regional trends of waitlist (WL) registrations and removal for liver transplantation (LT) among United States (US) adults listed for…
2021 American Transplant Congress
Adults Undergoing First Time Liver Transplantation with Biliary Atresia: An Analysis of the United Network for Organ Sharing Database
E. Hsu¹, J. Perkins², S. P. Horslen¹, A. A. Dick¹, N. M. Blondet¹, J. D. Reyes²
¹Seattle Children's Hospital, Seattle, WA, ²Surgery, University of Washington School of Medicine, Seattle, WA
*Purpose: Although biliary atresia (BA) is the most common indication for liver transplantation in children, there is no published data on outcomes for individuals who…
2021 American Transplant Congress
Validation of a Novel Gene Expression Biomarker of Rejection Following Liver Transplantation
J. Levitsky¹, M. Kandpal¹, T. Whisenant², K. Guo¹, S. Kurian³, M. Abecassis⁴
¹Gastroenterology & Hepatology; Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²University of California San Diego, San Diego, CA, ³Scripps Clinic, La Jolla, CA, ⁴University of Arizona College of Medicine Tucson, Tucson, AZ
*Purpose: Non-invasive biomarkers distinguishing early signs of immune activation vs. quiescence could more objectively guide immunosuppression management after liver transplantation (LT). Our aim was to…
2021 American Transplant Congress
Clinical Correlation of Frailty Measures and Evaluation of Complementary Molecular Frailty Biomarker Candidates in a Prospective National Cohort of Liver Transplant Candidates
S. Cremen¹, M. Robinson², T. Gallagher¹
¹Department of Hepatobiliary and Transplant Surgery, St Vincent's University Hospital, Dublin, Ireland, ²Department of Biology, Maynooth University, Kildare, Ireland
*Purpose: Frailty is a clinical condition characterized by a loss of physiologic reserve and increased susceptibility to stressors. Molecular frailty biomarkers may reflect the dysregulation…
2021 American Transplant Congress
The Confluence of Race, Socioeconomic Deprivation, and Waitlist Mortality for Children Awaiting Liver Transplant
S. Wadhwani¹, J. Ge¹, L. Gottlieb¹, C. Lyles¹, A. F. Beck², J. Bucuvalas³, U. Kotagal², J. C. Lai¹
¹University of California San Francisco, San Francisco, CA, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Social determinants like racism, ethnocentrism, and neighborhood socioeconomic deprivation are associated with poor outcomes for children after liver transplant. We studied the relationship between…
2021 American Transplant Congress
Primary Outcome of OPTIMAL: A Prospective Multicenter Trial of Immunosuppression Withdrawal (ISW) in Stable Adult Liver Transplant (LT) Recipients
S. Chandran¹, K. Mason², L. F. Sun¹, N. Tanimine³, M. DesMarais¹, B. Burrell¹, J. F. Markmann³
¹ITN, San Francisco, CA, ²Rho, Inc., Durham, NC, ³MGH, Boston, MA
*Purpose: To identify clinical & mechanistic correlates of successful ISW and operational tolerance (OT) in a selected cohort of adult LT recipients.*Methods: The Immune Tolerance…
2021 American Transplant Congress
Myeloid Yap Signaling is Required for Hepatic Cytoprotection in Liver Ischemia-reperfusion Injury
B. Yang¹, Z. Xue¹, C. Zhang², Y. Zhang², Y. Liu², J. Kupiec-Weglinski¹, H. Ji¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Dept of Surgery, Zhejiang University, Hangzhou, China
*Purpose: Liver ischemia-reperfusion injury (IRI) is recognized as an innate immunity-driven local inflammation response during hemorrhagic shock, liver resection and transplantation. Yes-associate protein 1 (YAP)…
2021 American Transplant Congress
COVID-19 Infection in Kidney versus Non-kidney Solid Organ Transplant Recipients: A Single Center Study
J. Schaenman¹, H. Byford², T. R. Grogan³, S. Fraschilla², K. Meneses⁴, J. C. Alejos⁵, M. Rivera⁶, S. Saab⁷
¹Infectious Diseases, UCLA, Los Angeles, CA, ²Transplant Administration, UCLA, Los Angeles, CA, ³Division of General Internal Medicine and Health Services Research, UCLA, Los Angeles, CA, ⁴Liver Transplantation, UCLA, Los Angeles, CA, ⁵Pediatric Heart Transplantation, UCLA, Los Angeles, CA, ⁶Pediatric Kidney Transplantation, UCLA, Los Angeles, CA, ⁷Liver Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: The COVID-19 pandemic has caused significant morbidity and mortality in patients around the world. A significant impact has been observed in immunocompromised patients such…
2021 American Transplant Congress
Blood Pressure Variability Immediately After Liver Transplant Predicts the Likelihood of Long-Term Cardiovascular Events
K. N. Truitt¹, K. Chen², Y. Yano³, D. Gregory⁴, L. B. VanWagner⁵
¹Northwestern Memorial Hospital, Chicago, IL, ²Harvard University, Cambridge, MA, ³Duke University School of Medicine, Durham, NC, ⁴Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Northwestern University Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: Cardiovascular disease is a leading cause of mortality in liver transplant recipients (LTRs). Adequate blood pressure (BP) control within one year after liver transplant…
2021 American Transplant Congress
Impact of Donation After Circulatory Death Donor Allografts on Outcomes Following Liver Transplantation for Cholangiocarcinoma
S. Kumar¹, S. Lin², J. D. Schold²
¹Digestive Disease Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates, ²Department of Quantitative Health Sciences, Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Improvements in the management of extra-hepatic cholangiocarcinoma (CCA) resulted in allocation of a standardized model for end-stage liver disease (MELD) exception score for liver…